scholarly journals Radiotherapy for Colorectal Cancer: Current Standards and Future Perspectives

2016 ◽  
Vol 32 (3) ◽  
pp. 172-177 ◽  
Author(s):  
Matthias F. Häfner ◽  
Jürgen Debus
Keyword(s):  
Colorectal Cancer ◽  
Future Perspectives ◽  
Current Standards

scholarly journals Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Fei Long ◽  
Zhi Lin ◽  
Liang Li ◽  
Min Ma ◽  
Zhixing Lu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Molecular Mechanisms ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Circular Rnas ◽  
Future Perspectives ◽  
Cis Acting ◽  
New Class ◽  
Functional Peptides ◽  
Mirna Sponges

AbstractColorectal cancer (CRC) is a common hereditary tumor that is often fatal. Its pathogenesis involves multiple genes, including circular RNAs (circRNAs). Notably, circRNAs constitute a new class of noncoding RNAs (ncRNAs) with a covalently closed loop structure and have been characterized as stable, conserved molecules that are abundantly expressed in tissue/development-specific patterns in eukaryotes. Based on accumulating evidence, circRNAs are aberrantly expressed in CRC tissues, cells, exosomes, and blood from patients with CRC. Moreover, numerous circRNAs have been identified as either oncogenes or tumor suppressors that mediate tumorigenesis, metastasis and chemoradiation resistance in CRC. Although the regulatory mechanisms of circRNA biogenesis and functions remain fairly elusive, interesting results have been obtained in studies investigating CRC. In particular, the expression of circRNAs in CRC is comprehensively modulated by multiple factors, such as splicing factors, transcription factors, specific enzymes and cis-acting elements. More importantly, circRNAs exert pivotal effects on CRC through various mechanisms, including acting as miRNA sponges or decoys, interacting with RNA binding proteins, and even translating functional peptides. Finally, circRNAs may serve as promising diagnostic and prognostic biomarkers and potential therapeutic targets in the clinical practice of CRC. In this review, we discuss the dysregulation, functions and clinical significance of circRNAs in CRC and further discuss the molecular mechanisms by which circRNAs exert their functions and how their expression is regulated. Based on this review, we hope to reveal the functions of circRNAs in the initiation and progression of cancer and highlight the future perspectives on strategies targeting circRNAs in cancer research.

scholarly journals Fluorescence-guided surgery in colorectal cancer; A review on clinical results and future perspectives

2021 ◽  
Author(s):  
Hidde A. Galema ◽  
RubenP.J. Meijer ◽  
Lorraine J. Lauwerends ◽  
Cornelis Verhoef ◽  
Jacobus Burggraaf ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Results ◽  
Future Perspectives ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

Current standards and new trends in the primary treatment of colorectal cancer

2011 ◽  
Vol 47 ◽  
pp. S312-S314 ◽  
Author(s):  
Alexander Stein ◽  
Djordje Atanackovic ◽  
Carsten Bokemeyer
Keyword(s):  
Colorectal Cancer ◽  
Primary Treatment ◽  
Current Standards
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