Deep Brain Stimulation for Status Dystonicus: A Case Series and Review of the Literature

2016 ◽  
Vol 94 (4) ◽  
pp. 207-215 ◽  
Author(s):  
Sharona Ben-Haim ◽  
Virginia Flatow ◽  
Tyler Cheung ◽  
Catherine Cho ◽  
Michele Tagliati ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Case Series ◽  
Review Of The Literature ◽  
Status Dystonicus ◽  
Deep Brain

scholarly journals Deep brain stimulation versus pallidotomy for status dystonicus: a single-center case series

2019 ◽  
pp. 1-11 ◽  
Author(s):  
Vincenzo Levi ◽  
Giovanna Zorzi ◽  
Giuseppe Messina ◽  
Luigi Romito ◽  
Irene Tramacere ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Statistical Power ◽  
Case Series ◽  
Study Data ◽  
Risk Difference ◽  
Drug Resistant ◽  
Status Dystonicus ◽  
Deep Brain

OBJECTIVEFirst-line pharmacological therapies have shown limited efficacy in status dystonicus (SD), while surgery is increasingly reported as remediable in refractory cases. In this context, there is no evidence regarding which neurosurgical approach is the safest and most effective. The aim of this study was to assess the clinical outcomes and surgery-related complications of globus pallidus internus deep brain stimulation (GPi DBS) and pallidotomy for the treatment of drug-resistant SD.METHODSThe authors reviewed the records of patients with drug-resistant SD who had undergone GPi DBS or pallidotomy at their institution between 2003 and 2017. The severity of the dystonia was evaluated using the Barry-Albright Dystonia (BAD) Scale. Surgical procedures were performed bilaterally in all cases.RESULTSFourteen patients were eligible for inclusion in the study. After surgery, the mean follow-up was 40.6 ± 30 months. DBS ended the dystonic storm in 87.5% of cases (7/8), while pallidotomy had a success rate of 83.3% (5/6). No significant differences were observed between the two techniques in terms of failure rates (risk difference DBS vs pallidotomy −0.03, 95% CI −0.36 to 0.30), SD mean resolution time (DBS 34.8 ± 19 days, pallidotomy 21.8 ± 20.2 days, p > 0.05), or BAD scores at each postoperative follow-up (p > 0.05). The long-term hardware complication rate after DBS was 37.5%, whereas no surgery-related complications were noted following pallidotomy.CONCLUSIONSThe study data suggest that DBS and pallidotomy are equally safe and effective therapies for drug-resistant SD. The choice between the two techniques should be tailored on a case-by-case basis, depending on factors such as the etiology and evolution pattern of the underlying dystonia and the clinical conditions at the moment of SD onset. Given the limitation of the low statistical power of this study, further multicentric investigations are needed to confirm its findings.

Subthalamic nucleus deep brain stimulation for the treatment of secondary dystonia: A case series and review of literature

2017 ◽  
Vol 10 (4) ◽  
pp. 870-872 ◽  
Author(s):  
Jason Margolesky ◽  
Nathan Schoen ◽  
Walter Jermakowicz ◽  
Samir Sur ◽  
Iahn Cajigas ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Case Series ◽  
Review Of Literature ◽  
Secondary Dystonia ◽  
Deep Brain

Deep brain stimulation treated dystonia-trajectory via status dystonicus

2018 ◽  
Vol 33 (7) ◽  
pp. 1168-1173 ◽  
Author(s):  
Elodie Nerrant ◽  
Victoria Gonzalez ◽  
Christophe Milesi ◽  
Xavier Vasques ◽  
Diane Ruge ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Status Dystonicus ◽  
Deep Brain
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