Diagnostic Impacts of Serum CA-125 Levels, Pap Smear Evaluation, and Endometrial Sampling in Women with Endometrial Clear Cell Carcinoma

2016 ◽  
Vol 39 (5) ◽  
pp. 283-288 ◽  
Author(s):  
Nilufer Cetinkaya ◽  
İlker Selcuk ◽  
Bulent Ozdal ◽  
Mehmet M. Meydanli ◽  
Tayfun Gungor
Keyword(s):  
Cell Carcinoma ◽  
Pap Smear ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ca 125 ◽  
Endometrial Sampling

scholarly journals Clear Cell Carcinoma of Endometrium: A Clinical Review

2014 ◽  
Vol 2 (1) ◽  
pp. 15-19
Author(s):  
Rajani Rawat ◽  
Soniya Vishwakarma ◽  
Shikha Seth ◽  
Vaibhav Kanti ◽  
Pragati Mishra
Keyword(s):  
Endometrial Cancer ◽  
Cell Carcinoma ◽  
Clinical Review ◽  
Pap Smear ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Clinical Staging ◽  
Transvaginal Sonography ◽  
Histopathological Diagnosis ◽  
Management Protocol

ABSTRACT Clear cell carcinoma of endometrium is a rare (1-6%) but aggressive malignancy with high propensity of early extra-uterine spread. The usual presentation is postmenopausal bleeding and discharge as with other endometrial cancers but it does not have preceding hyperplastic stage, instead it develops from thin atrophic endometrium, therefore impossible to identify by the screening measures like Pap smear and transvaginal sonography. First step for early diagnosis of such unfavorable endometrial cancer should be endometrial biopsy. Histopathological diagnosis is mandatory to confirm the clear cells present in the endometrial sample before planning the management. Clinical staging is highly erroneous in clear cell endometrial cancer and should not be taken into consideration in management plan. Being a rare cancer, there is lack of true evidence on its management protocol. Here, we had tried to provide the review about the clear cell endometrial (CCE) cancer diagnosis and management along with a case report for clinical perspective. How to cite this article Seth S, Rawat R, Kanti V, Mishra P, Vishwakarma S. Clear Cell Carcinoma of Endometrium: A Clinical Review. J South Asian Feder Menopause Soc 2014;2(1):15-19.

scholarly journals Serum D-dimer, Albumin and Systemic Inflammatory Response Markers in Ovarian Clear Cell Carcinoma and Their Prognostic Implications

2020 ◽  
Author(s):  
Wei Chen ◽  
Siyuan Zhong ◽  
Boer Shan ◽  
Shuling Zhou ◽  
Xiaohua Wu ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Inflammatory Response ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Systemic Inflammatory Response ◽  
Ca 125 ◽  
Chemotherapy Response ◽  
Ovarian Clear Cell Carcinoma ◽  
D Dimer

Abstract Background: This study attempts to evaluate whether preoperative systemic inflammatory response (SIR) markers or other hematological variables, such as albumin, D-dimer, and carbohydrate antigen 125, play roles in predicting chemotherapy response and survival outcome in patients with ovarian clear cell carcinoma (OCCC).Methods: Preoperative leukocyte differential counts, as well as platelet, serum albumin, plasma D-dimer and CA-125 levels, were measured in patients with FIGO IC-IV ovarian clear cell cancer. The correlations of these hematological biomarkers with clinicopathological features, chemotherapy response, and survival outcomes were further analyzed. Survival time was estimated using the Kaplan-Meier model, whereas Cox regression was conducted for multivariate analysis.Results: Among the 84 patients, 28.6% were classified as platinum resistant, and 69.0% were platinum sensitive. Preoperative CA125, albumin, and D-dimer levels; neutrophil to lymphocyte ratios (NLR); and monocyte to lymphocyte ratios were significantly correlated with FIGO stage, residual tumor, and platinum response. Platelet to lymphocyte ratio was not related to platinum response (P=0.060). The median follow-up time was 28 months (range, 1 to 128 months). Preoperative CA125, albumin, and D-dimer levels were significant prognostic factors for overall survival (OS) and progression-free survival (PFS). In the univariate analysis, only NLR exhibited prognostic significance for PFS (P = 0.007). Multivariate analysis indicated that D-dimer > 3.27 (P = 0.001 for OS; P = 0.040 for PFS) and albumin <39.6 (P = 0.005 for OS and P = 0.041 for PFS) retained significance.Conclusions: Preoperative NLR has some predictive value for platinum resistance in patients with IC-IV stage OCCC but has little predictive effect on prognosis. Elevated D-dimer and reduced albumin might be potential biomarkers for worse response to first-line platinum-based chemotherapy and poor clinical outcomes.

scholarly journals The prognostic value of pretreatment CA-125 levels and CA-125 normalization in ovarian clear cell carcinoma: a two-academic-institute study

Oncotarget ◽  
2016 ◽  
Vol 7 (13) ◽  
pp. 15566-15576 ◽  
Author(s):  
Huimin Bai ◽  
Guisha Sha ◽  
Meizhu Xiao ◽  
Huiqiao Gao ◽  
Dongyan Cao ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Prognostic Value ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ca 125 ◽  
Ovarian Clear Cell Carcinoma

Prognostic Value of Serum CA19-9 and Perioperative CA-125 Levels in Ovarian Clear Cell Carcinoma

2018 ◽  
Vol 28 (6) ◽  
pp. 1108-1116
Author(s):  
Jun Zhu ◽  
Long Jiang ◽  
Hao Wen ◽  
Rui Bi ◽  
Xiaohua Wu ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Prognostic Value ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Ca 125 ◽  
Ovarian Clear Cell Carcinoma

scholarly journals Serum D-dimer, Albumin and Systemic Inflammatory Response Markers in Ovarian Clear Cell Carcinoma and Their Prognostic Implications

2020 ◽  
Author(s):  
Wei Chen ◽  
Siyuan Zhong ◽  
Boer Shan ◽  
Shuling Zhou ◽  
Xiaohua Wu ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Systemic Inflammatory Response ◽  
Ca 125 ◽  
Chemotherapy Response ◽  
Ovarian Clear Cell Carcinoma ◽  
Lymphocyte Ratio ◽  
D Dimer

Abstract Background The study aims to evaluate whether preoperative systemic inflammatory response (SIR) markers or other hematologic variables, such as albumin, D-dimer, carbohydrate antigen 125 play a role in predicting chemotherapy response and survival outcome in patients with ovarian clear cell carcinoma (OCCC). Methods Preoperative leukocyte differential counts, platelet, serum albumin, plasma D-dimer and CA-125 levels were measured in patients with FIGO IC-IV ovarian clear cell cancer. The correlations of these hematologic biomarkers with clinicopathological features, chemotherapy response, and survival outcomes were further analyzed. Survival time was estimated using the Kaplan-Meier model, whereas Cox regression was conducted for multivariate analysis.Results Among the 84 patients, 28.6% were classified as platinum-resistant and 69.0% as platinum sensitive. Preoperative CA125, albumin, D-dimer, and neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio were significantly correlated with FIGO stage, residual tumor, and platinum response. Platelet to lymphocyte ratio was not related to platinum response ( P =0.060). The median follow-up time was 28 months (range, 1 to 128 months). Preoperative CA125, albumin, and D-dimer were significant prognostic factors for overall survival (OS) and progression-free survival (PFS). In the univariate analysis, only NLR had prognostic significance for PFS ( P =0.007). Multivariate analysis indicated that D-dimer > 3.27 ( P = 0.001 for OS; P = 0.040 for PFS) and albumin <39.6 ( P = 0.005 for OS and P = 0.041 for PFS) retained significance.Conclusions Preoperative NLR has some predictive value for platinum resistance in patients with IC-IV stage OCCC, but has little predictive effect on prognosis. Elevated D-dimer and reduced albumin might be potential biomarkers for worse response to first-line platinum-based chemotherapy and poor clinical outcomes.

scholarly journals Mural Nodules of Clear Cell Carcinoma in a Mucinous Borderline Tumor of the Ovary: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Daniela S. Allende ◽  
Richard D. Drake ◽  
Longwen Chen
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Cystic Mass ◽  
Growth Patterns ◽  
Intestinal Type ◽  
Ca 125 ◽  
Borderline Tumor ◽  
Ovarian Mass ◽  
Mural Nodules

Mural nodules of ovarian mucinous borderline tumors are rare. In this study, we report a case of mural nodules of clear cell carcinoma in an intestinal type mucinous borderline tumor of the ovary. The patient was a 54-years-old woman presented with back and pelvic pain for 3 months. A right-sided multiloculated ovarian mass approximately 20 cm was identified on the CT scan. CA-125 was moderately elevated. She underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and bilateral pelvic and para-aortic lymphadenectomy. Grossly, the right ovarian mass showed a multiloculated cystic mass with mucinous fluid. There were papillations in the internal surface and two mural nodules were seen. Microscopic examination revealed that the cystic mass was an intestinal type borderline mucinous tumor. The mural nodules showed a classic histology of clear cell carcinoma with tubulocystic and papillary growth patterns. This is an extremely rare case of mural nodules of clear cell carcinoma arising in a mucinous borderline tumor.

scholarly journals Systemic Inflammatory Response Markers and CA-125 Levels in Ovarian Clear Cell Carcinoma: A Two Center Cohort Study

2016 ◽  
Vol 48 (1) ◽  
pp. 250-258 ◽  
Author(s):  
Hee Seung Kim ◽  
Hwa-Young Choi ◽  
Maria Lee ◽  
Dong Hoon Suh ◽  
Kidong Kim ◽  
...  
Keyword(s):  
Cohort Study ◽  
Inflammatory Response ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Systemic Inflammatory Response ◽  
Ca 125 ◽  
Ovarian Clear Cell Carcinoma

scholarly journals A RARE CASE OF CLEAR CELL CARCINOMA OF ENDOMETRIUM IN A POST-MENOPAUSAL WOMAN- A HISTOPATHOLOGICAL CASE REPORT

2021 ◽  
pp. 10-11
Author(s):  
Joyeeta Mandal ◽  
Manoj Kumar Paswan ◽  
Arpana Shailaly Tirkey ◽  
Sona Pathak
Keyword(s):  
Cell Carcinoma ◽  
Vaginal Bleeding ◽  
Pap Smear ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Relevant Literature ◽  
Endometrial Biopsy ◽  
Menopausal Woman ◽  
Histopathological Diagnosis ◽  
Post Menopausal

Clear cell carcinoma of endometrium is a rare but aggressive malignancy with high predisposition of early extra-uterine spread. It commonly presents with vaginal bleeding or discharge. Less commonly, it may be diagnosed subsequent to an abnormal pap smear. Endometrial biopsy is ideally the first step for early diagnosis of such unfavourable endometrial cancer. Histopathological diagnosis is mandatory to confirm the presence of clear cells in the endometrial sample before planning the course of treatment. Here, we report a case of a postmenopausal woman who presented with vaginal bleeding without a specific medical history. Endometrial biopsy was done and sample was sent to our department of Pathology for histopathological diagnosis. We report the case from a histopathological perspective with a brief review of the relevant literature.

scholarly journals Complete remission of heavily treated ovarian clear cell carcinoma with ARID1A mutations after pembrolizumab and bevacizumab combination therapy: a case report

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Yu-Chien Lin ◽  
Kuo-Chang Wen ◽  
Pi-Lin Sung ◽  
Yu-Ting Chou ◽  
Phui-Ly Liew ◽  
...  
Keyword(s):  
Complete Remission ◽  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Checkpoint Inhibitors ◽  
Genomic Analysis ◽  
Angiogenesis Inhibitors ◽  
Ca 125 ◽  
Ovarian Clear Cell Carcinoma ◽  
Platinum Based Chemotherapy

Abstract Background Patients with ovarian clear cell carcinoma (OCCC) have a poor prognosis because they show low sensitivity to platinum-based chemotherapy. New treatments for refractory OCCC are urgently needed. Case presentation We present a patient with refractory OCCC in whom conventional chemotherapy failed. Cachexia was induced by the disseminating recurrent tumors. Tumor tissue staining and genomic analysis revealed PD-L1 negativity, a low tumor burden, stable microsatellite instability, and two mutations in ARID1A. The patient was administered pembrolizumab combined with bevacizumab triweekly. Her serum CA-125 level decreased dramatically after the first cycle. A computerized tomography scan showed marked regression of the recurrent masses after 3 cycles, and the patient reached complete remission after 9 cycles. She showed good recovery from cachexia. We observed no marked side effects except for mild polyarthritis of the small joints. Conclusions The therapeutic effect of checkpoint inhibitors combined with angiogenesis inhibitors is very promising in our patient with OCCC. Further clinical trials of tumors including ARID1A mutations are warranted.

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