Acquired FVIII and FIX Inhibitors after Pregnancy: A Case Report

2016 ◽  
Vol 136 (4) ◽  
pp. 229-232 ◽  
Author(s):  
Murat Kose ◽  
Oguz Kagan Bakkaloglu ◽  
Shirkhan Amikishiyev ◽  
Timur Selcuk Akpınar ◽  
Basak Saracoglu ◽  
...  
Keyword(s):  
Case Report ◽  
Prothrombin Complex Concentrate ◽  
Clinical Presentation ◽  
Coagulation Factors ◽  
Bleeding Disorder ◽  
Acquired Hemophilia ◽  
Fviii Inhibitor ◽  
Activated Prothrombin Complex Concentrate ◽  
Life Threatening

Acquired hemophilia is a relatively rare clinical presentation, and most cases present with acquired FVIII inhibitor. The co-occurrence of inhibitors to multiple coagulation factors is uncommon. These autoantibodies may induce spontaneous life-threatening bleeding in patients who have had no previous bleeding disorder. Herein, we present a patient with postpartum acquired FVIII and FIX inhibitors who developed intramuscular hematoma and hemothorax during follow-up. She was then treated with activated prothrombin complex concentrate and methylprednisolone.

scholarly journals Perforation of the atrial wall and aortic sinus after closure of an atrial septal defect with an Atriasept occluder: a case report

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zai-Qiang Zhang ◽  
Jia-Wang Ding
Keyword(s):  
Case Report ◽  
Atrial Septal Defect ◽  
Septal Defect ◽  
Emergency Operation ◽  
Atrial Wall ◽  
Aortic Sinus ◽  
Case Presentation ◽  
Lethal Complications ◽  
Life Threatening

Abstract Background While the perforation of the atrial wall and aortic sinus after closure of an atrial septal defect (ASD) is rare, it’s life-threatening, with rapid progress and high mortality. To the best of our knowledge, 21 similar cases have been reported since 1976. Case presentation We report a 16-year-old male whose atrial septal defect (ASD) was closed using a 12-mm Amplatzer septal occluder (ASO). Atrial wall and aortic sinus perforation occurred 3 months after transcatheter closure, and the patient was discharged after emergency operation. He was discharged on the 12th postoperative day in good overall condition. Conclusions With this case report, we want to illustrate that although percutaneous closure of ASD is regarded as a routine procedure, we should not forget the potentially lethal complications, especially cardiac erosion. Therefore, we should carefully evaluate the risk of erosion before surgery, and careful lifelong follow-up is needed.

scholarly journals Complicated staphylococcal pericarditis in a child: a case report

2020 ◽  
Vol 7 (11) ◽  
pp. 2252
Author(s):  
Fehmida Sultana ◽  
Deepti Jujaray ◽  
Ravi P. V. Kiran
Keyword(s):  
Case Report ◽  
Pericardial Effusion ◽  
Early Identification ◽  
Clinical Presentation ◽  
Paediatric Population ◽  
Acute Pericarditis ◽  
Life Threatening

Although primary pericarditis is unusually experienced and diagnosed in paediatric population, it has probable life threatening sequel. This case report presents a case of complicated community acquired staphylococcal pericarditis, which illustrates how evasive the diagnosis of pericardial effusion can be. Early identification of pericarditis and pericardial effusion is vital to enable emergent intervention to enhance prognosis and alleviate mortality. The purpose of this report is to probe into the etiology of acute pericarditis and also to review the clinical presentation, the management and complications connected with acute pericarditis. 

The EMDR DeTUR protocol for the treatment of self-injury in a patient with severe personality disorder: a case report

2019 ◽  
Vol 5 (1) ◽  
pp. 27-38
Author(s):  
Phyllis Annesley ◽  
Adedayo Alabi ◽  
Laura Longdon
Keyword(s):  
Case Report ◽  
Factitious Disorder ◽  
Content Type ◽  
Self Injury ◽  
Life Threatening ◽  
History Of ◽  
Mental Health Difficulties ◽  
Healthcare Interventions ◽  
Therapy Sessions

Purpose The purpose of this paper is to describe the Eye movement desensitisation and reprocessing (EMDR) treatment of an adult female patient detained within a high secure hospital with complex mental health difficulties, including complex trauma, factitious disorder, self-injury and a history of offending. The EMDR treatment addressed the patient’s urges to engage in severe and sometimes life-threatening self-injury, a primary motive of which was to access physical healthcare interventions within a general hospital. The paper describes the wide-ranging benefits of the treatment and incorporates feedback from the patient and clinicians within her multi-disciplinary team (MDT). Design/methodology/approach Four triggers for self-injury were processed during the therapy using the DeTUR Protocol (Popky, 2005, 2009) and the Constant Installation of Present Orientation and Safety (CIPOS, Knipe, 2009a) method. In total, 18 one hour therapy sessions were delivered plus three follow-up sessions to continue to offer support and complete the post-treatment evaluation. Findings The level of urge for each trigger was reduced to 0 which the patient defined as “no urge to self-injure”. Benefits went well beyond self-injury with reported positive impacts on mood, thinking, sleep, concentration, memory and experience of flashbacks. Practical implications This case report demonstrates that the EMDR DeTUR Protocol together with the CIPOS method can be extremely valuable in the treatment of patients who self-injure. Originality/value The case report offers an important contribution to an area that requires much further research.

scholarly journals Use of anterolateral thigh flap for reconstruction of traumatic bilateral hemipelvectomy after major pelvic trauma: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Saleh Al-wageeh ◽  
Faisal Ahmed ◽  
Khalil Al-naggar ◽  
Mohammad Reza Askarpour ◽  
Ebrahim Al-shami
Keyword(s):  
Case Report ◽  
Cause Of Death ◽  
Axial Skeleton ◽  
High Energy ◽  
Pelvic Trauma ◽  
Anterolateral Thigh Flap ◽  
Trauma Patients ◽  
Anterolateral Thigh ◽  
Life Threatening

Abstract Background Major pelvic trauma (MPT) with traumatic hemipelvectomy (THP) is rare, but it is a catastrophic health problem caused by high-energy injury leading to separation of the lower extremity from the axial skeleton, which is associated with a high incidence of intra-abdominal and multi-systemic injuries. THP is generally performed as a lifesaving protocol to return the patient to an active life. Case report A 12-year male patient exposed to major pelvic trauma with bilateral THP survived the trauma and multiple lifesaving operations. The anterolateral thigh flap is the method used for wound reconstruction. The follow-up was ended with colostomy and cystostomy with wheelchair mobilization. To the best of our knowledge, there have been a few bilateral THP reports, and our case is the second one to be successfully treated with an anterolateral thigh flap. Conclusion MPT with THP is the primary cause of death among trauma patients. Life-threatening hemorrhage is the usual cause of death, which is a strong indication for THP to save life.

Sequential Infusion of rFVIIa and Plasma-Derived Activated Prothrombin Complex Concentrate In Haemophilia A Paediatric Patient with Inhibitors

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4660-4660
Author(s):  
Giuseppe Lassandro ◽  
Francesco Antonio Scaraggi ◽  
Rosanna Scaraggi ◽  
Teresa Capriati ◽  
Domenico De Mattia ◽  
...  
Keyword(s):  
Prothrombin Complex Concentrate ◽  
Conflicts Of Interest ◽  
Coagulation Factors ◽  
High Titre ◽  
Left Knee ◽  
Haemophilia A ◽  
Activated Prothrombin Complex Concentrate ◽  
End Of Treatment ◽  
Inhibitor Titre ◽  
Bypassing Agents

Abstract Abstract 4660 One of the serious complication in hemophilia therapy is the development of high titre inhibitors to FVIII and less often to others coagulation factors. It makes treatment of bleeds very challenging. We report a case of hemarthrosis in hemophilia A pediatric patient with inhibitors, treated with sequential infuson of rFVIIa (rFVIIa, NOVOSEVEN; Novo Nordisk A/S, Bagsvaerd, Denmark) and plasma activated prothrombin complex concentrate (pd- aPCC, FEIBA; Baxter AG Vienna Austria). rFVIIa and plasma activated prothrombin complex concentrate are, indeed, used as haemostatic bypassing agents to prevent eaemorrages, with the goal of limiting sequelae as arthropathy, or to control quickly heamostasis as intensive on–demand treatment. A 3 years old male patient affected by haemophilia A with inhibitors came to our observation for a traumatic hemarthrosis of the left knee. Clinic examination showed swelling and pain. His inhibitor titre was 29 Bethesda Units. First we infused rFVIIa for seven consecutive days at the dose of 90 ug/kg every 3 hours. This therapy didn't determinate any clinical improvement. Then we infused plasma activated prothrombin complex concentrate for the next consecutive seven days at the dose of 60 UI/kg every 12 hours. At the end of treatment we noticed pain disappearance and reducing swelling. Medical literature recently describes similar paediatric cases treated with sequential infusion of rFVIIa and plasma activated prothrombin complex concentrate. Our positive experience could stimulate to use haemostatic bypassing agents because apparently safe. We encourage to use this therapeutic scheme because it seem to reduce healing times of acute events. Disclosures: No relevant conflicts of interest to declare.

Bladder hemangioma. Case report and review of the literature

1994 ◽  
Vol 61 (2) ◽  
pp. 151-153
Author(s):  
M. Marcellini ◽  
R. Cantiani ◽  
G. Mainiero ◽  
L Neri
Keyword(s):  
Case Report ◽  
Clinical Presentation ◽  
Age Of Onset ◽  
Partial Cystectomy ◽  
Definitive Treatment ◽  
Review Of The Literature ◽  
Bladder Hemangioma ◽  
One Year

The Authors report a case of vesical hemangioma; it was typical for site and clinical presentation whereas the age of onset and gross appearance were atypical. A TUR biopsy was performed without complications, but did not confirm diagnosis. A partial cystectomy was performed. A one-year follow-up, negative for recurrence, confirmed this procedure as the definitive treatment of choice.

scholarly journals Recurrent hepatobiliary sepsis in a patient with von Meyenburg complexes: a case report and review of the literature

2016 ◽  
Vol 26 (2) ◽  
pp. 133-136 ◽  
Author(s):  
Doreen Siew Ching Koay ◽  
Wei Qiang Leow ◽  
Thuan Tong Tan ◽  
Gabrielle Slapak
Keyword(s):  
Liver Transplantation ◽  
Case Report ◽  
Congenital Malformation ◽  
Medical Therapy ◽  
Clinical Presentation ◽  
Review Of The Literature ◽  
Unique Case ◽  
Von Meyenburg Complex ◽  
Life Threatening ◽  
Immunodeficiency States

The von Meyenburg complex (VMC) is a rare, congenital malformation of the ductal plate. It is typically asymptomatic and usually discovered incidentally. We report a unique case of recurrent life-threatening hepatobiliary sepsis caused by VMC and a review of the literature. A 62-year-old man presented with recurrent episodes of life-threatening hepatobiliary sepsis. Extensive investigations only showed that he has VMCs without any other source of sepsis or underlying immunodeficiency states. Despite prolonged courses of antibiotics which resolved each episode of sepsis, he suffers repeated recurrences of hepatobiliary sepsis. Liver transplantation is now being considered in view of his refractoriness to medical therapy. As VMC can present with severe hepatobiliary sepsis, it is therefore essential to recognise its presence. This case adds to the literature the atypical but life-threatening clinical presentation of VMC.

scholarly journals Mucocele of the glands of blandin nuhn: a case report

2013 ◽  
pp. 46-47 ◽  
Author(s):  
Nathalia García-León ◽  
Gilberto E Marrugo
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Clinical Presentation ◽  
Surgical Excision ◽  
Diagnosis And Treatment ◽  
Vascular Lesions ◽  
Benign Lesions ◽  
Recurrent Lesion ◽  
Timely Diagnosis

Mucoceles arising from the Blandin Nuhn glands are uncommon benign lesions of the oral cavity, which by their clinical presentation may be confused with more serious diseases such as vascular lesions, pyogenic granulomas, polyps, or squamous papillomas; thereby, it is convenient to be aware of the characteristics of this entity to guide the accurate and timely diagnosis and treatment. Herein, we present a case of a 10-year-old patient with a recurrent lesion of this type, which required surgical excision and marsupialization of the same, with no evidence of recurrence during follow-up.

scholarly journals Chondroblastoma of thoracic vertebra in young adult causing paraparesis

2017 ◽  
Vol 31 (3) ◽  
pp. 335-338
Author(s):  
Pramod J. Giri ◽  
Vaibhav S. Chavan
Keyword(s):  
Case Report ◽  
World Literature ◽  
Clinical Presentation ◽  
Rare Condition ◽  
Thoracic Vertebra ◽  
Complete Excision ◽  
The World ◽  
Posterior Element ◽  
Almost All

Abstract Chondroblastoma of spine is very rare condition. To best of our knowledge, fewer than 30 cases have been reported in the world literature. Almost all of them involved both anterior & posterior component of vertebra. There are only few reports with isolated posterior element involvement. Clinical presentation of paraparesis because of vertebral chondroblastoma is very rare. This case report presents 17 yr old male with chondroblastoma involving posterior thoracic vertebra presenting with quadriparesis which improved after successful treatment. Early diagnosis and complete excision with periodic follow up is necessary for treatment of this disease.

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