Differentiation between Melanin-Laden Macrophages and Melanoma Cells in Vitreous Aspirates

2016 ◽  
Vol 60 (1) ◽  
pp. 25-30
Author(s):  
Ernest Iakovlev ◽  
Zeina Ghorab ◽  
Hatem Krema ◽  
Vladimir Iakovlev ◽  
Peter Kertes ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Retinal Detachment ◽  
Melanoma Cells ◽  
Melanoma Metastasis ◽  
Vitreous Fluid ◽  
Diagnostic Features ◽  
Pigmented Lesions ◽  
Atypical Cells ◽  
History Of ◽  
A Current

Objective: The differential diagnosis between retinal detachment and melanoma metastatic to the vitreous can be challenging, both clinically and cytologically. We demonstrate the diagnostic features and pitfalls of the cytological assessment. Study Design: A case of a metastatic melanoma to the vitreous is compared to a case of retinal detachment initially suspected as melanoma metastasis. Case 1 was a 54-year-old patient with a vague history of pigmented lesions 20 years previously and a current presentation of a visual defect. Case 2 was a 68-year-old patient with a history of melanoma and a presentation of floaters and flashing lights. Results: The vitreous fluid of case 1 contained atypical, pigment-laden cells positive for HMB-45 and assessed as melanoma. On enucleation, a melanoma metastatic to the vitreous was diagnosed. The vitreous fluid of case 2 revealed atypical cells containing pigment granules. The cells were negative for melanocytic markers, while the granules stained positive for melanin. Macrophage marker CD163 was positive in all cells. The interpretation was one of macrophages reactive to the retinal detachment. Conclusion: Melanin-laden macrophages can mimic melanoma cells. This needs to be considered in the differential diagnosis. Additional stains can help the distinction.

scholarly journals Clinical history of HIV infection may be misleading in cytopathology

CytoJournal ◽  
2010 ◽  
Vol 7 ◽  
pp. 7 ◽  
Author(s):  
Liron Pantanowitz* ◽  
Michael Kuperman ◽  
Robert A. Goulart
Keyword(s):  
Differential Diagnosis ◽  
Hiv Infection ◽  
Primary Effusion Lymphoma ◽  
Clinical History ◽  
Hiv Status ◽  
Ct Guided ◽  
Increased Risk ◽  
Spindle Cell Proliferation ◽  
Atypical Cells ◽  
History Of

Human immunodeficiency virus (HIV)-infected patients are at an increased risk for developing opportunistic infections, reactive conditions and neoplasms. As a result, a broad range of conditions are frequently included in the differential diagnosis of HIV-related lesions. The clinical history of HIV infection may, however, be misleading in some cases. Illustrative cases are presented in which knowledge of a patient's HIV status proved to be misleading and increased the degree of complexity of the cytologic evaluation. Case 1 involved the fine needle aspiration (FNA) of a painful 3 cm unilateral neck mass in a 38-year-old female with generalized lymphadenopathy. Her aspirate revealed a spindle cell proliferation devoid of mycobacteria that was immunoreactive for S-100 and macrophage markers (KP-1, PGM1). Multiple noncontributory repeat procedures were performed until a final excision revealed a schwannoma. Case 2 was a CT-guided FNA of a positron emission tomography positive lung mass in a 53-year-old man. The acellular aspirate in this case contained structures resembling fungal spore forms that were negative for mucicarmine and GMS stains, as well as cryptococcal antigen immunocytochemistry. A Von Kossa stain confirmed that these pseudo-fungal structures were calcified debris. Follow up revealed multiple calcified lung and hilar node based granulomata. Case 3 involved the cytologic evaluation of pleural fluid from a 47-year-old man with Kaposi sarcoma and recurrent chylous pleural effusions. Large atypical cells identified in his effusion were concerning for primary effusion lymphoma. Subsequent pleural biopsy revealed extramedullary hematopoiesis, documenting these atypical cells as megakaryocytes. These cases demonstrate that knowledge of a patient's HIV status can be misleading in the evaluation of cytology specimens, with potential for misdiagnosis and/or multiple procedures. To avoid this pitfall in the setting of HIV infection, common entities unrelated to HIV infection and artifacts should always be included in the differential diagnosis.

Differential Diagnosis of Retinoblastoma and Conditions Simulating Retinoblastoma (Pseudoretinoblastoma)

2020 ◽  
pp. 51-58
Author(s):  
D.P. Volodin ◽  
◽  
A.V. Kotelnikova ◽  
E.S. Kotova ◽  
A.A. Yarovoy ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Key Words ◽  
Review Article ◽  
Diagnostic Features ◽  
Modern Classification ◽  
History Of

The review article provides literature data related to the history of differential diagnosis of retinoblastoma and lesions simulating retinoblastoma (pseudoretinoblastomas), provides a modern classification of pseudoretinoblastomas, describes clinical and diagnostic features that allow to differentiate these conditions. The analysis of Russian and foreign publications on main pseudoretinoblastomas requiring differential diagnosis with retinoblastoma in pediatric ophthalmological practice was carried out. Key words: ophthalmology, retinoblastoma, lesions simulating retinoblastoma, pseudoretinoblastomas, differential diagnosis.

Post-Soviet economy development: From the past to the future

2017 ◽  
pp. 5-21 ◽  
Author(s):  
E. Yasin
Keyword(s):  
Present Situation ◽  
Soviet Economy ◽  
Market Reforms ◽  
Democratic Development ◽  
The Past ◽  
Current Period ◽  
The Future ◽  
History Of ◽  
Working Out ◽  
A Current

The article is devoted to major events in the history of the post-Soviet economy, their influence on forming and development of modern Russia. The author considers stages of restructuring, market reforms, transformational crisis, and recovery growth (1999-2011), as well as a current period which started in2011 and is experiencing serious problems. The present situation is analyzed, four possible scenarios are put forward for Russia: “inertia”, “mobilization”, “decisive leap”, “gradual democratic development”. More than 30 experts were questioned in the process of working out the scenarios.

Distribution, systematics and nomenclature of the three taxa of Common Stonechats (Aves, Passeriformes, Muscicapidae, Saxicola) that breed in the Caucasian region

2020 ◽  
Vol 29 (1) ◽  
pp. 33-57
Author(s):  
V.M. Loskot ◽  
G.B. Bakhtadze
Keyword(s):  
Geographic Distribution ◽  
Habitat Preferences ◽  
Junior Synonym ◽  
Type Locality ◽  
Diagnostic Features ◽  
Western Turkey ◽  
Geographical Variations ◽  
History Of ◽  
The Individual ◽  
North Western

Geographic distribution and habitat preferences of Saxicola rubicola rubicola (Linnaeus, 1766), S. maurus variegatus (S.G. Gmelin, 1774), and S. m. armenicus (Stegman, 1935) inhabiting the Caucasian Isthmus and adjacent areas are described in detail. We examined the individual, sexual, age, seasonal and geographical variations of seven main diagnostic features of both plumage and morphometrics (exactly, the length of wing and tail) using 381 skin specimens. Substantially improved diagnoses of S. m. variegatus and S. m. armenicus are provided. After a thorough examination of the materials and history of the expedition of Samuel Gmelin in 1768–1774, and his description of Parus variegatus, it was concluded that the type locality of this taxon was the vicinity of Shamakhi in Azerbaijan not Enzeli in North-Western Turkey. It is also shown the fallacy of the recently proposed attribution of the holotype of the northern subspecies S. m. variegatus to the southern taxon S. m. armenicus and synonymisation of these names, as well as the replacement of the name S. m. variegatus by its junior synonym S. m. hemrichii Ehrenberg, 1833 for the northern subspecies.

scholarly journals Giant Fibrovascular Polyp as an Unusual Cause of Globus Pharyngeus

2021 ◽  
pp. 014556132110039
Author(s):  
Jelena Sotirović ◽  
Ljubomir Pavićević ◽  
Stanko Petrović ◽  
Saša Ristić ◽  
Aleksandar Perić
Keyword(s):  
Differential Diagnosis ◽  
Asymptomatic Patient ◽  
Histopathological Examination ◽  
Complete Resection ◽  
Airway Compromise ◽  
Endoscopic Removal ◽  
Globus Sensation ◽  
Fibrovascular Polyp ◽  
History Of ◽  
Fatal Complications

Differential diagnosis of globus sensation in an otherwise asymptomatic patient should include hypopharyngeal fibrovascular polyp to avoid potentially fatal complications like airway compromise following regurgitation. We present a case of a 74-year-old man with a 13-cm long hypopharyngeal fibrovascular polyp with 9 months history of globus sensation. A narrow stalk of the giant polyp allowed endoscopic removal and complete resection with the CO2 laser. Histopathological examination was conclusive for the fibrovascular polyp.

scholarly journals Undifferentiated pleomorphic sarcoma in oropharyngeal mucosa of patients with multiple basal cell carcinomas

Rare Tumors ◽  
2021 ◽  
Vol 13 ◽  
pp. 203636132110264
Author(s):  
Andrea Dekanić ◽  
Marko Velepič ◽  
Margita Belušić Gobić ◽  
Ita Hadžisejdić ◽  
Nives Jonjić
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell ◽  
Polypoid Lesion ◽  
Older Patient ◽  
Mesenchymal Tumors ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
Basal Cell Carcinomas ◽  
History Of ◽  
Multiple Basal Cell Carcinomas

Malignant mesenchymal tumors of oropharyngeal mucosa are rare. Those with fibroblastic and histiocytic differentiation in the skin are called atypical fibroxanthoma (AFX) and in the soft tissue undifferentiated pleomorphic sarcoma (UPS). Here we present a case of an older patient with a history of multiple basal cell carcinomas and recently with a rapidly growing polypoid lesion in the mucosa of posterior oropharyngeal wall with AFX/UPS morphology. The differential diagnosis, histological pitfalls of this poorly characterized mesenchymal lesions, and the challenges associated with treatment are discussed.

scholarly journals Neonate born with ischemic limb to a COVID-19 positive mother: management and review of literature

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shahana Perveen ◽  
Karmaine A. Millington ◽  
Suchitra Acharya ◽  
Amit Grag ◽  
Vita Boyar
Keyword(s):  
Differential Diagnosis ◽  
Compartment Syndrome ◽  
Upper Extremity ◽  
Preterm Neonate ◽  
Review Of Literature ◽  
Case Presentation ◽  
Ischemic Limb ◽  
History Of ◽  
Hand Amputation ◽  
Work Up

AbstractObjectivesTo describe challenges in diagnosis and treatment of congenital neonatal gangrene lesions associated with history of maternal coronavirus disease 2019 (COVID-19) infection.Case presentationA preterm neonate was born with upper extremity necrotic lesions and a history of active maternal COVID-19 infection. The etiology of his injury was challenging to deduce, despite extensive hypercoagulability work-up and biopsy of the lesion. Management, including partial forearm salvage and hand amputation is described.ConclusionsNeonatal gangrene has various etiologies, including compartment syndrome and intrauterine thromboembolic phenomena. Maternal COVID-19 can cause intrauterine thrombotic events and need to be considered in a differential diagnosis.

scholarly journals Photoconduction of Polar and Nonpolar Cuts of Undoped Sr0.61Ba0.39Nb2O6 Single Crystals

Crystals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 780
Author(s):  
Elke Beyreuther ◽  
Julius Ratzenberger ◽  
Matthias Roeper ◽  
Benjamin Kirbus ◽  
Michael Rüsing ◽  
...  
Keyword(s):  
Electrical Measurement ◽  
Excitation Wavelength ◽  
Trap States ◽  
Strontium Barium Niobate ◽  
Strontium Barium ◽  
Current Voltage ◽  
History Of ◽  
A Current ◽  
Complex Manner

In the last two decades, variably doped strontium barium niobate (SBN) has attracted a lot of scientific interest mainly due to its specific non-linear optical response. Comparably, the parental compound, i.e., undoped SBN, appears to be less studied so far. Here, two different cuts of single-crystalline nominally pure strontium barium niobate in the composition Sr0.61Ba0.39Nb2O6 (SBN61) are comprehensively studied and analyzed with regard to their photoconductive responses. We present conductance measurements under systematically varied illumination conditions along either the polar z-axis or perpendicular to it (x-cut). Apart from a pronounced photoconductance (PC) already under daylight and a large effect upon super-bandgap illumination in general, we observe (i) distinct spectral features when sweeping the excitation wavelength over the sub-bandgap region as then discussed in the context of deep and shallow trap states, (ii) extremely slow long-term relaxation for both light-on and light-off transients in the range of hours and days, (iii) a critical dependence of the photoresponse on the pre-illumination history of the sample, and (iv) a current–voltage hysteresis depending on both the illumination and the electrical-measurement conditions in a complex manner.

scholarly journals Intravitreal Silicone Oil Migration Into the Lateral Cerebral Ventricles

2019 ◽  
Vol 3 (6) ◽  
pp. 466-473
Author(s):  
Jessica L. Cao ◽  
Andrew W. Browne ◽  
Thomas Clifford ◽  
Sumit Sharma ◽  
Vivek Patel
Keyword(s):  
Case Report ◽  
Retinal Detachment ◽  
Literature Review ◽  
Current Literature ◽  
Symptom Management ◽  
Silicone Oil ◽  
Cerebral Ventricles ◽  
Oil Migration ◽  
Intraocular Tamponade ◽  
History Of

Purpose: Silicone oil (SO) is often used as an intraocular tamponade in repairs of retinal detachments. It may be associated with complications such as cataract, glaucoma, keratopathy, subretinal migration of oil, fibrous epiretinal and sub retinal proliferations, and oil emulsification. The purpose of this report is to describe a rare phenomenon of intraocular silicone oil migration into the cerebral ventricles, which may later be mistaken for intraventricular hemorrhages on neuroimaging. Methods: Case report with literature review. Results: A patient with a history of retinal detachment repair with intraocular SO presented with headaches. Neuroimaging revealed SO migration to the cerebral ventricles. The patient was treated conservatively with symptom management and headaches resolved. Conclusions: We present a case of intraocular SO migration to the cerebral ventricles and review the current literature. We also propose two mechanisms for this phenomenon.

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