scholarly journals Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor

2016 ◽  
Vol 8 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Kosuke Shido ◽  
Taku Fujimura ◽  
Aya Kakizaki ◽  
Sadanori Furudate ◽  
Masayuki Asano ◽  
...  
Keyword(s):  
Case Report ◽  
Local Recurrence ◽  
Recurrence Rate ◽  
Local Recurrence Rate ◽  
Present Report ◽  
Malignant Potential ◽  
Immunomodulatory Effects ◽  
High Local Recurrence Rate ◽  
Mesenchymal Neoplasm ◽  
Plexiform Fibrohistiocytic Tumor

Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206- tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.

Plexiform Fibrohistiocytic Tumor: A Brief Review

2007 ◽  
Vol 131 (7) ◽  
pp. 1135-1138
Author(s):  
Altaf Taher ◽  
Chitra Pushpanathan
Keyword(s):  
Local Recurrence ◽  
Growth Patterns ◽  
High Local Recurrence Rate ◽  
Complete Surgical Resection ◽  
Mesenchymal Neoplasm ◽  
Long Term Follow Up ◽  
Subcutaneous Mass ◽  
Children And Young Adults ◽  
Painless Mass ◽  
Plexiform Fibrohistiocytic Tumor

Abstract Plexiform fibrohistiocytic tumor is a rare mesenchymal neoplasm of intermediate malignancy, first reported by Enzinger and Zhang in 1988. It has a predilection for children and young adults but can occur at any age. The tumor usually involves the upper limbs as a slow-growing, painless mass. The tumor has a high local recurrence rate but metastasizes only rarely. Histologically, the tumor is characterized by poorly demarcated dermal or subcutaneous mass with multinodular plexiform growth and fibrohistiocytic cytomorphology. There are three distinct recognized growth patterns: fibrohistiocytic, fibroblastic, and mixed types. The tumor displays uniform immunoreactivity for vimentin and CD68. Ultrastructurally, the tumor cells have features of myofibroblasts and histiocyte-like cells. Complete surgical resection of the tumor, preferably with wider margins, is required to prevent local recurrence. Long-term follow-up is necessary to detect any nodal or pulmonary metastasis.

Re-excision of anterior margins for breast cancer is associated with a low local recurrence rate

2013 ◽  
Vol 39 (11) ◽  
pp. S66-S67
Author(s):  
Layal El-Asir ◽  
Faizan Jabbar ◽  
George Boundouki ◽  
Clive Griffith ◽  
James Harvey
Keyword(s):  
Breast Cancer ◽  
Local Recurrence ◽  
Recurrence Rate ◽  
Local Recurrence Rate

Do pathological fractures influence survival and local recurrence rate in bony sarcomas?

2007 ◽  
Vol 43 (13) ◽  
pp. 1944-1951 ◽  
Author(s):  
J.A.M. Bramer ◽  
A.A. Abudu ◽  
R.J. Grimer ◽  
S.R. Carter ◽  
R.M. Tillman
Keyword(s):  
Local Recurrence ◽  
Recurrence Rate ◽  
Local Recurrence Rate ◽  
Pathological Fractures
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