ENETS Consensus Guidelines Update for the Management of Distant Metastatic Disease of Intestinal, Pancreatic, Bronchial Neuroendocrine Neoplasms (NEN) and NEN of Unknown Primary Site

2016 ◽  
Vol 103 (2) ◽  
pp. 172-185 ◽  
Author(s):  
M. Pavel ◽  
D. O''Toole ◽  
F. Costa ◽  
J. Capdevila ◽  
D. Gross ◽  
...  
Keyword(s):  
Metastatic Disease ◽  
Primary Site ◽  
Unknown Primary ◽  
Neuroendocrine Neoplasms ◽  
Unknown Primary Site ◽  
Consensus Guidelines ◽  
Distant Metastatic Disease

scholarly journals Diagnostic Approaches to Neuroendocrine Neoplasms of Unknown Primary Site

2019 ◽  
Vol 110 (7-8) ◽  
pp. 563-573
Author(s):  
Alison May Berner ◽  
Christodoulos Pipinikas ◽  
Anna Ryan ◽  
Harpreet Dibra ◽  
Ismail Moghul ◽  
...  
Keyword(s):  
Primary Site ◽  
Molecular Techniques ◽  
Unknown Primary ◽  
Neuroendocrine Neoplasms ◽  
Unknown Primary Site ◽  
Biochemical Tests ◽  
Endocrine Differentiation ◽  
Systemic Treatments ◽  
Diagnostic Approaches ◽  
Site Identification

Neuroendocrine neoplasms (NENs) arise from cells of neuronal and endocrine differentiation. While they are a rare entity, an increasing proportion of patients with NEN present with metastatic disease and no evident primary site using routine imaging or histopathology. NENs of unknown primary site have a poorer prognosis, often due to the challenge of selecting appropriate evidence-based management. We review the available literature and guidelines for the management of NENs of unknown primary site including clinical features, biochemical tests, histopathology, imaging, surgical exploration and localised and systemic treatments. We also discuss novel molecular techniques currently under investigation to aid primary site identification.

scholarly journals Risk factors and predictors for tumor site origin in metastatic adenocarcinoma of unknown primary site

2021 ◽  
Author(s):  
Xinrong Li ◽  
Yan Shao ◽  
Liqiang Sheng ◽  
Junquan Zhu ◽  
Zeming Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Site ◽  
Unknown Primary ◽  
Tumor Site ◽  
Metastatic Adenocarcinoma ◽  
Unknown Primary Site

scholarly journals Baseline Staging of Melanoma with Unknown Primary Site: The Value of Serum S100 Protein and Positron Emission Tomography

Dermatology ◽  
2008 ◽  
Vol 217 (4) ◽  
pp. 351-355 ◽  
Author(s):  
Patrick A. Oberholzer ◽  
Mirjana Urosevic ◽  
Hans C. Steinert ◽  
Reinhard Dummer
Keyword(s):  
Positron Emission Tomography ◽  
S100 Protein ◽  
Primary Site ◽  
Emission Tomography ◽  
Unknown Primary ◽  
Unknown Primary Site ◽  
Positron Emission ◽  
Baseline Staging
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