The Promise of Epigenetics. Has It Delivered New Insights?

2016 ◽  
Vol 34 (1-2) ◽  
pp. 12-19 ◽  
Author(s):  
Judy H. Cho
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Disease Prevention ◽  
Critical Role ◽  
Mononuclear Phagocytes ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Specific Gene ◽  
Interleukin 23

Enrichment of GWAS signals within cell-specific enhancers defines cellular subsets most associated to IBD and highlights the critical role of epigenetics in IBD. We review the central role of the interleukin 23 (IL-23) pathway in cellular plasticity, mechanisms which are significantly mediated by epigenetic regulation of master transcription factors of various CD4+ T-cell subsets. Present studies need to be complemented by a deeper understanding of intestine-specific gene expression and epigenetics, especially in mononuclear phagocytes, given their enormous plasticity, and tissue-dependent function. A deeper understanding and application of epigenetics may impact and guide early treatment and ultimately, disease prevention in IBD.

scholarly journals Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors

2002 ◽  
Vol 21 (19) ◽  
pp. 5225-5234 ◽  
Author(s):  
Xun Wang ◽  
John D. Crispino ◽  
Danielle L. Letting ◽  
Minako Nakazawa ◽  
Mortimer Poncz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Specific Gene ◽  
Ets Transcription Factors ◽  
Specific Gene Expression

scholarly journals Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy

Cancers ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 260
Author(s):  
Myriam Ben Ben Khelil ◽  
Yann Godet ◽  
Syrine Abdeljaoued ◽  
Christophe Borg ◽  
Olivier Adotévi ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cancer Immunotherapy ◽  
Cd4 T Cells ◽  
Critical Role ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Cancer Therapies ◽  
The Impact

Over the past decades, CD4+ T cells have been considered as a supporting actor in the fields of cancer immunotherapy. Until recently, accumulating evidence has demonstrated the critical role of CD4+ T cells during antitumor immunity. CD4+ T cells can either suppress or promote the antitumor cytotoxic CD8+ T cell responses, either in secondary lymphoid organs or in the tumor. In this review, we provide an overview of the multifaceted role of different CD4+ T cell subsets in cancer immune response and their contribution during cancer therapies. Specifically, we focus on the latest progress regarding the impact of CD4+ T cell modulation on immunotherapies and other cancer therapies and discuss the prospect for harnessing CD4+ T cells to control tumor progression and prevent recurrence in patients.

scholarly journals STAT5 and CD4+ T Cell Immunity

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 32 ◽  
Author(s):  
David L. Owen ◽  
Michael A. Farrar
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
Critical Role ◽  
Cell Types ◽  
T Cell Immunity ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Cell Immunity ◽  
And Function

STAT5 plays a critical role in the development and function of many cell types. Here, we review the role of STAT5 in the development of T lymphocytes in the thymus and its subsequent role in the differentiation of distinct CD4+ helper and regulatory T-cell subsets.

scholarly journals Role of cyclic AMP in the control of cell-specific gene expression

1993 ◽  
Vol 4 (6) ◽  
pp. 204-209 ◽  
Author(s):  
Wolfgang Schmid ◽  
Doris Nitsch ◽  
Michael Boshart ◽  
Günther Schütz
Keyword(s):  
Gene Expression ◽  
Cyclic Amp ◽  
Specific Gene ◽  
Specific Gene Expression

The critical role of CD4+ T-cell help in immunity to HIV

Vaccine ◽  
2002 ◽  
Vol 20 (15) ◽  
pp. 1961-1963 ◽  
Author(s):  
Jonathan Luke Heeney
Keyword(s):  
T Cell ◽  
Critical Role ◽  
Cd4 T Cell ◽  
Cd4 T Cell Help ◽  
T Cell Help
Sign in / Sign up

Export Citation Format

Share Document