Phospholipid Composition in Synthetic Surfactants Is Important for Tidal Volumes and Alveolar Stability in Surfactant-Treated Preterm Newborn Rabbits

Neonatology ◽  
2016 ◽  
Vol 109 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Andrea Calkovska ◽  
Bim Linderholm ◽  
Marie Haegerstrand-Björkman ◽  
Barbara Pioselli ◽  
Nicola Pelizzi ◽  
...  
Keyword(s):  
Phospholipid Composition ◽  
Preterm Newborn ◽  
Alveolar Stability ◽  
Synthetic Surfactants

Alveolar metabolism of natural vs. synthetic surfactants in preterm newborn rabbits

2001 ◽  
Vol 90 (1) ◽  
pp. 198-204 ◽  
Author(s):  
Victoria Allen ◽  
Margaret Oulton ◽  
Dora Stinson ◽  
Josee MacDonald ◽  
Alexander Allen
Keyword(s):  
Active Form ◽  
Lamellar Body ◽  
Biologically Active ◽  
The Other ◽  
Phospholipid Content ◽  
Adult Rabbit ◽  
Preterm Newborn ◽  
Alveolar Surfactant ◽  
Synthetic Surfactants

We compared the recoveries of four surfactant preparations: two natural [term fetal rabbit surfactant (FRS) and adult rabbit surfactant (ARS)] and two commercially available preparations [apoprotein-based Survanta (S) and synthetic Exosurf (E)] from 27-day gestation rabbit pups treated at birth and ventilated up to 120 min. At 5, 60, and 120 min, we measured the recovery of the heavy-aggregate, metabolically active form (H) and the light-aggregate, nonsurface active metabolic breakdown form (L) of alveolar surfactant and determined the phospholipid content and composition of the intracellularly stored lamellar body (LB) pool. Pups treated with FRS had <15% loss of H by 2 h. ARS-treated pups had a >50% loss of H by 1 h, and E- and S-treated pups had ∼50% loss by 5 min, with a slower rate of continuing loss of up to 80% by 2 h. The major losses of H phospholipid were not explained by the L-form recovery. LB phospholipid significantly increased only in the E-treated pups and only at 2 h. FRS provides a biologically active form (H) of surfactant that appeared to remain in the airway for a significantly longer time than the other surfactant preparations. The unique properties of FRS merit further study.

Platelet Functions in Relation to Dietary Fats in Farmers from two Regions of France

1978 ◽  
Vol 40 (02) ◽  
pp. 518-531 ◽  
Author(s):  
S Renaud ◽  
E Dumont ◽  
F Godsey ◽  
A Suplisson ◽  
C Thevenon
Keyword(s):  
Platelet Aggregation ◽  
Platelet Rich Plasma ◽  
Plasma Cholesterol ◽  
Phospholipid Composition ◽  
Saturated Fat ◽  
Phosphatidyl Inositol ◽  
Phosphatidyl Serine ◽  
Dietary Fats ◽  
Platelet Phospholipid ◽  
Platelet Functions

SummaryTo determine whether the long-term feeding of dietary fats affect platelet functions in man, platelet aggregation (to thrombin ADP, collagen, epinephrine) and clotting activity of platelet-rich plasma (PRP), platelet-poor plasma and of washed platelets, were studied in a mobile-laboratory in 44 healthy male farmers (40-45 years) from two French regions Var and Moselle, in relation to lipemia, glycemia, dietary nutriments, and platelet phospholipid composition. In the Moselle subjects, the platelet clotting activity of PRP and of washed platelets, the platelet aggregation to thrombin and ADP, were highly significantly (p <0.001) increased as compared to those of Var, but not the plasma cholesterol, which was identical in the two regions.In Moselle, the intake of total calories, total lipids and saturated fats was higher than in the Var.However, it was only with the saturated fat intake (mostly stearic acid) that the platelet clotting activity (p <0.01) and the platelet aggregation (p <0.001) were highly significantly correlated. The platelet clotting activity was also significantly (p <0.001) correlated with the fatty acid composition of the platelet phospholipid fractions phosphatidyl serine + phosphatidyl inositol.

Clostridium perfringens intestinal gas gangrene in a preterm newborn

2008 ◽  
Vol 212 (S 1) ◽  
Author(s):  
CA Hanke ◽  
R Hentschel ◽  
R Berner ◽  
A Superti-Furga ◽  
KD Rückauer ◽  
...  
Keyword(s):  
Clostridium Perfringens ◽  
Gas Gangrene ◽  
Preterm Newborn ◽  
Intestinal Gas

Proceedings: Changes in the phospholipid composition of spermatozoa in the reproductive tract of the ram

Reproduction ◽  
1974 ◽  
Vol 36 (2) ◽  
pp. 442-443 ◽  
Author(s):  
A Poulos ◽  
P. Brown ◽  
R Cox ◽  
I. White
Keyword(s):  
Reproductive Tract ◽  
Phospholipid Composition

Phospholipid Composition of Mitochondria of Gills of Pike (Esox lucius) under the Zinc Ions Impact

2013 ◽  
Vol 49 (6) ◽  
pp. 98-101
Author(s):  
Yu. I. Senyk ◽  
V. O. Khomenchuk ◽  
V. Z. Kurant ◽  
V. V. Grubinko
Keyword(s):  
Phospholipid Composition ◽  
Esox Lucius ◽  
Zinc Ions ◽  
Pike Esox Lucius
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