The Effect of Aging and the High-Frequency Auditory Threshold on Speech-Evoked Mismatch Negativity in a Noisy Background

2015 ◽  
Vol 21 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Junming Chen ◽  
Suijun Chen ◽  
Yiqing Zheng ◽  
Yongkang Ou
Keyword(s):  
Auditory Processing ◽  
High Frequency ◽  
Mismatch Negativity ◽  
Pure Tone ◽  
The Elderly ◽  
Elderly Subjects ◽  
Control Group ◽  
Central Auditory Processing ◽  
Hearing Thresholds ◽  
Noisy Background

Mismatch negativity (MMN) has been widely used to study the function of central auditory processing in the elderly. However, current research has not yet considered the effect of noise and high-frequency hearing threshold on MMN in the elderly. The aim of this study was to evaluate the effect of aging and high-frequency hearing loss on speech-related MMN in noisy backgrounds. Additionally, the possible mechanisms of central auditory processing dysfunction in the elderly were investigated. Fifty people aged 61-80 (70 ± 5.8) years were recruited for this study. They were divided into a 61- to 70-year-old group and a 71- to 80-year-old group. Fifty younger adults aged 21-40 (31 ± 5.3) years were recruited as healthy controls. Pure-tone hearing thresholds were recorded. A speech discrimination score (SDS) and a speech-evoked MMN under white noise with a bandwidth from 125 to 8,000 Hz background condition were recorded. The relationships between SDS and MMN latency and amplitude were analyzed. The effects of age and binaural 2,000-, 4,000- and 8,000-Hz pure-tone hearing thresholds on MMN latency and amplitude were analyzed. We found that the hearing thresholds of 2,000, 4,000 and 8,000 Hz in the 61- to 70-year-old and 71- to 80-year-old groups were higher than those in the control group. The SDS in a noisy background in the 61- to 70-year-old and 71- to 80-year-old groups were lower than those in the control group. Speech-evoked MMN latency was longer in the 61- to 70-year-old and in the 71- to 80-year-old groups than in the control group (215.8 ± 14.2 ms). SDS and speech-evoked MMN latency were negatively correlated. Age and speech-evoked MMN latency were positively correlated, as were the binaural 4,000- to 8,000-Hz pure-tone hearing thresholds and speech-evoked MMN. This study suggests that in elderly subjects, the function of preattentive central auditory processing changes. Additionally, increasing age and high-frequency hearing thresholds create a synergy in neurons that is weakened in the MMN time window, which may be a cause of central auditory processing disorders in elderly subjects in noisy background conditions.

AUDIOLOGICAL CORRELATES OF AGE-RELATED MANIFESTATIONS OF AUDITORY DISORDERS

2020 ◽  
pp. 549-554
Author(s):  
Л. Е. Голованова ◽  
Е. А. Огородникова ◽  
Н. С. Белокурова ◽  
Е. С. Лаптева ◽  
М. Ю. Бобошко
Keyword(s):  
Hearing Aids ◽  
Auditory Processing ◽  
Pure Tone ◽  
Young Patients ◽  
Pure Tone Audiometry ◽  
Sound Field ◽  
Speech Audiometry ◽  
Central Auditory Processing ◽  
Central Auditory Processing Disorder ◽  
Age Related

Целью исследования был сравнительный анализ жалоб и аудиологических показателей у пациентов сурдологического центра в зависимости от возраста. Представлены результаты обследования 300 первичных пациентов (случайная выборка), обратившихся к сурдологу-оториноларингологу в течение 1 мес. В группу молодых пациентов (19-44 года) вошли 40 человек; в группу среднего возраста (45- 59 лет) - 62 человека; в группу пожилых (60-74 года) - 100 человек; в группу старческого возраста (75-90 лет) - 98 человек. Обследование включало сбор жалоб и анамнеза, ЛОР-осмотр, тональную пороговую аудиометрию, импедансометрию, речевую аудиометрию в наушниках для выявления признаков центральных слуховых расстройств или в свободном звуковом поле для оценки эффективности слухопротезирования. Установлено, что для ранней диагностики тугоухости и профилактики возрастных сенсорнокогнитивных дисфункций целесообразно использовать не только результаты тональной пороговой аудиометрии, но и данные речевой аудиометрии, а также анализ субъективных жалоб. Результаты работы свидетельствуют о необходимости организации скрининга состояния слуха в рамках диспансеризации населения старше 60 лет. The aim of the study was a comparative analysis of complaints and audiological findings in patients of the audiological center depending on their age. The results of the examination of 300 fi rstly consulted patients (random sample) are presented. The group of young patients (19-44 years) included 40 people; middle age (45-59 years) - 62 people; elderly (60-74 years) - 100 people; senile age (75-90 years) - 98 people. The survey included the collection of complaints and anamnesis, ENT checkup, pure tone audiometry, impedancemetry, speech audiometry in headphones to detect the signs of Central Auditory Processing Disorder or in the free sound field to assess the effectiveness of hearing aids. It was found that for early diagnosis of hearing loss and prevention of age-related sensory-cognitive dysfunction, it is advisable to use not only the results of pure tone audiometry, but also the data of speech audiometry, as well as the analysis of subjective complaints. The results of the work indicate the need for hearing screening in the population over 60 years old.

The Effect of Citalopram Versus a Placebo on Central Auditory Processing in the Elderly

2017 ◽  
Vol 38 (9) ◽  
pp. 1233-1239 ◽  
Author(s):  
Jose Fernando Polanski ◽  
Alexandra Dezani Soares ◽  
Liliane Desgualdo Pereira ◽  
Oswaldo Laercio de Mendonça Cruz
Keyword(s):  
Auditory Processing ◽  
The Elderly ◽  
Central Auditory Processing

scholarly journals Event related potentials in cases of amblyaudia

2020 ◽  
Vol 6 (4) ◽  
pp. 747
Author(s):  
Wessam Mostafa Essawy
Keyword(s):  
Auditory Processing ◽  
Event Related Potentials ◽  
Speech Development ◽  
Screening Tests ◽  
Control Group ◽  
Auditory Information ◽  
Central Auditory Processing ◽  
Auditory Processing Disorders ◽  
Central Auditory Processing Disorders ◽  
Related Potentials

<p class="abstract"><strong>Background:</strong> Amblyaudia is a weakness in the listener’s binaural processing of auditory information. Subjects with amblyaudia also demonstrate binaural integration deficits and may display similar patterns in their evoked responses in terms of latency and amplitude of these responses. The purpose of this study was to identify the presence of amblyaudia in a population of young children subjects and to measure mismatch negativity (MMN), P300 and cortical auditory evoked potentials (CAEPs) for those individuals.</p><p class="abstract"><strong>Methods:</strong> Subjects included in this study were divided into 2 groups control group that consisted of 20 normal hearing subjects with normal developmental milestones and normal speech development. The study group (GII) consisted of 50 subjects with central auditory processing disorders (CAPDs) diagnosed by central auditory screening tests. </p><p class="abstract"><strong>Results:</strong> With using dichotic tests including dichotic digits test (DDT) and competing sentence test (CST), we could classify these cases into normal, dichotic dysaudia, amblyaudia, and amblyaudia plus with percentages (40%, 14%, 38%, 8% respectively). Using event related potentials, we found that P300 and MMN are more specific in detecting neurocognitive dysfunction related to allocation of attentional resources and immediate memory in these cases.</p><p class="abstract"><strong>Conclusions:</strong> The presence of amblyaudia in cases of central auditory processing disorders (CAPDs) and event related potentials is an objective tool for diagnosis, prognosis and follow up after rehabilitation.</p>

scholarly journals P3 Cognitive Potential in Cochlear Implant Users

2018 ◽  
Vol 22 (04) ◽  
pp. 408-414 ◽  
Author(s):  
Signe Grasel ◽  
Mario Greters ◽  
Maria Goffi-Gomez ◽  
Roseli Bittar ◽  
Raimar Weber ◽  
...  
Keyword(s):  
Speech Recognition ◽  
Cochlear Implant ◽  
Auditory Processing ◽  
Evoked Potential ◽  
Control Group ◽  
Central Auditory Processing ◽  
Speech Discrimination ◽  
Significant Difference ◽  
Cortical Responses ◽  
Peripheral Auditory System

Introduction The P3 cognitive evoked potential is recorded when a subject correctly identifies, evaluates and processes two different auditory stimuli. Objective to evaluate the latency and amplitude of the P3 evoked potential in 26 cochlear implant users with post-lingual deafness with good or poor speech recognition scores as compared with normal hearing subjects matched for age and educational level. Methods In this prospective cohort study, auditory cortical responses were recorded from 26 post-lingual deaf adult cochlear implant users (19 with good and 7 with poor speech recognition scores) and 26 control subjects. Results There was a significant difference in the P3 latency between cochlear implant users with poor speech recognition scores (G-) and their control group (CG) (p = 0.04), and between G- and cochlear implant users with good speech discrimination (G+) (p = 0.01). We found no significant difference in the P3 latency between the CG and G+. In this study, all G- patients had deafness due to meningitis, which suggests that higher auditory function was impaired too. Conclusion Post-lingual deaf adult cochlear implant users in the G- group had prolonged P3 latencies as compared with the CG and the cochlear implant users in the G+ group. The amplitudes were similar between patients and controls. All G- subjects were deaf due to meningitis. These findings suggest that meningitis may have deleterious effects not only on the peripheral auditory system but on the central auditory processing as well.

Evaluation of Hearing and Balance Functions of Patients with Sickle Cell Anemia

2018 ◽  
Vol 23 (2) ◽  
pp. 122-125 ◽  
Author(s):  
Elif Tugba Sarac ◽  
Bilgehan Boke ◽  
Semsettin Okuyucu
Keyword(s):  
Hearing Loss ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Pure Tone ◽  
Mixed Type ◽  
Normal Hearing ◽  
Spontaneous Nystagmus ◽  
Control Group ◽  
Hearing Thresholds ◽  
Significant Difference

Introduction: Sickle cell anemia is a disease characterized by a wide vaso-occlusive incident from micro-vascular incident to muscularactivity. The cochlear function can also get affected by this vaso-occlusion. Objective: It is aimed at determining what kind of effects sickle cell anemia has on hearing and balance system. Methods: This study has been conducted on 46 patients with sickle cell anemia and 45 healthy individuals. For all participants, their pure tone hearing thresholds and videonystagmography (VNG) findings have been determined in 17 frequencies between 125–16.000 Hz. Results: All hearing thresholds between 125 and 16,000 Hz, pure tone averages of patients with sickle cell anemia have been found statistically significant to be higher than the corresponding values in the control group(p < 0.05). The normal hearing rate of patients with sickle cell anemia has been determined to be 71.1% conductive hearing loss (CHL) to be 4.4%, sensorineural hearing loss (SNHL) to be 22.2%, and mixed type hearing loss to be 2.2% in right ear; the normal hearing rate has been determined to be 71.1%, CHL to be 2.2%, SNHL to be 22.2%, and mixed type hearing loss to be 4.4% in left ear. Statistically significant difference has not been found between head shake, spontaneous nystagmus, optokinetic, tracking test batteries, static and dynamic positional tests used in VNG, saccade accuracy and saccade peak velocity, which are saccadic test findings of 2 groups. However, saccadic latency, which is a saccadic test finding, has been determined to be longer in patients with sickle cell anemia in comparison to the control group. Conclusion: While sickle cell anemia causes hearing deficits, it does not have any effect on the central or peripheral vestibular system.

scholarly journals Adverse plasma fatty acid composition in patients with femoral neck fracture1

2020 ◽  
Vol 98 (2) ◽  
pp. 61-66
Author(s):  
Aleksandra Arsic ◽  
Goran Pesic ◽  
Snjezana Petrovic ◽  
Aleksandar Matic ◽  
Jovana Jeremic ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Thiobarbituric Acid ◽  
The Elderly ◽  
Nutritional Intervention ◽  
Femoral Neck Fractures ◽  
Fracture Repair ◽  
Elderly Subjects ◽  
Control Group ◽  
Total N ◽  
Tnf Α

Our study aimed to examine the status of plasma fatty acids (FAs), inflammatory markers, and lipid peroxidation in patients with femoral neck fractures. The study included 20 patients (64–86 years) with femoral neck fractures indicated for surgery and a control group of 17 elderly subjects without fractures or serious chronic diseases. Plasma was obtained during the first 12 h postfracture and presurgery and 7 days postop. Compared to the control, patients had significantly higher saturated FA (SFA) and monounsaturated FA as well as increased TNF-α and IL-6. Opposite to that, levels of individual and total n-6 polyunsaturated FA (PUFA), individual and total n-3 PUFA, n-6/n-3 ratio, and levels of thiobarbituric acid reactive substances (TBARS) were markedly lower in the patient than in the controls. On the seventh day after the surgery, we showed a further rise in the SFA, oleic acid, and TNF-α and reductions of n-6 PUFA and IL-6. Taken together, our results suggest that altered FA status, especially reduced PUFA, may influence hip fracture repair and even contribute to femoral fracture susceptibility in the elderly. A potential benefit from nutritional intervention with PUFA in prevention and (or) fracture healing should be considered.

Evaluation of the supervisory system in elderly subjects with and without disinhibition

2000 ◽  
Vol 15 (7) ◽  
pp. 407-415 ◽  
Author(s):  
E Gokalsing ◽  
P.H. Robert ◽  
V Lafont ◽  
I Medecin ◽  
C Baudu ◽  
...  
Keyword(s):  
Performance Test ◽  
Neuropsychological Test ◽  
Continuous Performance Test ◽  
The Elderly ◽  
Test Sequence ◽  
Elderly Subjects ◽  
Control Group ◽  
General Context ◽  
Boston Naming Test ◽  
Supervisory System

Disinhibition and irritability, defined as loss of behavioral and emotional control, are frequent in the elderly. The working hypothesis for this study was that these disorders are associated with a cognitive alteration of control processes that manifests as non-routine behavior because of the dysfunction of a general executive component known as the supervisory attentional system (SAS).MethodsA total of 28 elderly subjects with mild cognitive impairment were recruited and divided into two groups using the Neuropsychiatric Inventory. Fourteen subjects were allocated to the disinhibited group and 14 subjects matched for age, sex and educational level formed a disinhibition-free control group. The neuropsychological battery included the following tests: Mini Mental Score Evaluation, Boston Naming test, Token test, Trail Making and Verbal Fluency. Two tasks were specifically designed to stress the SAS: 1) A specific verbal sentence arrangement task in which subjects had to use sequential reasoning with verbal material. Each test sequence consisted of a series of words shown in jumbled order. The construction of some sequences had to be done by using familiar routine associations (valid conditions). In contrast, other sequences required the overriding selection of familiar routine associations, which were inappropriate within the general context of the task (invalid conditions). 2) Using the Continuous Performance Test, four aspects were evaluated: sustained, selective, preparation and suppressive attention.ResultsThe only group differences in neuropsychological test results were the following: 1) the sentence arrangement task. In comparison with the control group, the disinhibited group was impaired in invalid conditions and the calculated difference between the number of correct responses in invalid conditions minus that in valid conditions was significantly higher; and 2) the CPT. Disinhibited subjects had a significantly lower number of hits, exclusively in the ‘suppressive attention’ paradigm.These results suggest that subjects with disinhibition have impaired supervisory system function.

The mismatch negativity (MMN) – A unique window to disturbed central auditory processing in ageing and different clinical conditions

2012 ◽  
Vol 123 (3) ◽  
pp. 424-458 ◽  
Author(s):  
R. Näätänen ◽  
T. Kujala ◽  
C. Escera ◽  
T. Baldeweg ◽  
K. Kreegipuu ◽  
...  
Keyword(s):  
Auditory Processing ◽  
Mismatch Negativity ◽  
Central Auditory Processing ◽  
Clinical Conditions

Differential Diagnosis of Speech Sound Disorder (Phonological Disorder): Audiological Assessment beyond the Pure-tone Audiogram

2015 ◽  
Vol 26 (04) ◽  
pp. 423-435 ◽  
Author(s):  
Vasiliki Vivian Iliadou ◽  
Gail D. Chermak ◽  
Doris-Eva Bamiou
Keyword(s):  
Auditory Processing ◽  
Pure Tone ◽  
Case Reports ◽  
Full Range ◽  
Speech Sound ◽  
Pure Tone Audiometry ◽  
Central Auditory Processing ◽  
Auditory Function ◽  
Speech Sound Disorder ◽  
Auditory Nervous System

Background: According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, diagnosis of speech sound disorder (SSD) requires a determination that it is not the result of other congenital or acquired conditions, including hearing loss or neurological conditions that may present with similar symptomatology. Purpose: To examine peripheral and central auditory function for the purpose of determining whether a peripheral or central auditory disorder was an underlying factor or contributed to the child’s SSD. Research Design: Central auditory processing disorder clinic pediatric case reports. Study Sample: Three clinical cases are reviewed of children with diagnosed SSD who were referred for audiological evaluation by their speech–language pathologists as a result of slower than expected progress in therapy. Results: Audiological testing revealed auditory deficits involving peripheral auditory function or the central auditory nervous system. These cases demonstrate the importance of increasing awareness among professionals of the need to fully evaluate the auditory system to identify auditory deficits that could contribute to a patient’s speech sound (phonological) disorder. Conclusions: Audiological assessment in cases of suspected SSD should not be limited to pure-tone audiometry given its limitations in revealing the full range of peripheral and central auditory deficits, deficits which can compromise treatment of SSD.

The Clinical Utility of the P3 AERP in Children With Auditory Processing Disorders

1992 ◽  
Vol 35 (4) ◽  
pp. 903-912 ◽  
Author(s):  
Robert E. Jirsa
Keyword(s):  
Treatment Program ◽  
Auditory Processing ◽  
Clinical Utility ◽  
Clinical Status ◽  
Normal Control Group ◽  
Behavioral Changes ◽  
Control Group ◽  
Central Auditory Processing ◽  
Auditory Processing Disorders ◽  
Central Auditory Processing Disorders

This study investigated whether the P3 AERP could be used to reflect behavioral changes resulting from therapeutic intervention in a group of children with central auditory processing disorders (CAPDs). Results showed a significant decrease in P3 latency, along with a significant increase in P3 amplitude, following a structured treatment program. No changes occurred in either the CAPD control group or in the normal control group. These results suggest that the P3 AERP latency and amplitude measures are sensitive to changes in clinical status following a treatment program.

Sign in / Sign up

Export Citation Format

Share Document