scholarly journals Metaplastic Breast Carcinoma with Unusual Presentation: Review of Three Cases

Breast Care ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. 404-407 ◽  
Author(s):  
M. Asunción Fernández Pérez ◽  
Isabel Viqueira Rodriguez ◽  
Alberto Tello Royloa ◽  
Javier Martínez Guisasola
Keyword(s):  
Breast Carcinoma ◽  
Large Mass ◽  
The Other ◽  
Metaplastic Carcinoma ◽  
Breast Lump ◽  
Fast Growing ◽  
Mesenchymal Differentiation ◽  
Myoepithelial Differentiation ◽  
The Mean ◽  
Metaplastic Breast Carcinoma

Background: Metaplastic breast carcinoma is an uncommon type of breast cancer that usually appears as a large, fast growing breast lump. Case Report: We report 3 cases of metaplastic breast carcinoma presented at our clinic in 2014. The mean age at diagnosis was 67.3 years. 1 patient presented with a fast growing, large mass detected by herself. However, in the other 2 patients, the nodule was approximately 1.5 cm in size, not fast growing, and was detected on mammography. All 3 patients were treated surgically (2 lumpectomies and 1 mastectomy), with the final pathology of metaplastic carcinoma with chondroid mesenchymal differentiation in 2 cases and metaplastic carcinoma with myoepithelial differentiation in the 3rd case. The patients are still under adjuvant therapy. Conclusions: Metaplastic breast carcinoma may present unusually as a non-palpable lump. This entity must be considered in any breast lump.

Spindle Cell Metaplastic Breast Carcinoma

2021 ◽  
Vol 17 ◽  
Author(s):  
Vithya Sanmugasiva ◽  
Marlina Tanty Ramli Hamid ◽  
Farhana Fadzli ◽  
Nazimah Ab Mumin ◽  
Kartini Rahmat
Keyword(s):  
Breast Carcinoma ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Final Diagnosis ◽  
Spindle Cell Carcinoma ◽  
Left Breast ◽  
Metaplastic Carcinoma ◽  
Breast Cancers ◽  
Breast Lump ◽  
Metaplastic Breast Carcinoma

Introduction: Metaplastic breast carcinoma is an uncommon malignancy that constitutes < 5% of all breast cancers. There are 5 subtypes which are spindle cell, squamous cell, carcinosarcoma, matrix-producing and metaplastic with osteoclastic giant cells. Spindle cell carcinoma represents approximately <0.3% of invasive breast carcinomas. It is typically a triple-negative cancer with distinct pathological characteristics, but relatively a non-conclusive imaging findings. Case report: An elderly lady presented with an enlarging painful left breast lump for 1 year. Palpable left breast lump noted on clinical examination. Mammography demonstrated a high density, oval lesion with a partially indistinct margin. Corresponding ultrasound showed a large irregular heterogeneous lesion with solid-cystic areas. Histopathology showed atypical spindle-shaped cells which stained positive for cytokeratins and negative for hormone and human epidermal growth factor receptors, which favours spindle cell metaplastic carcinoma. Left mastectomy and axillary dissection were performed, and the final diagnosis was consistent with metaplastic spindle cell carcinoma. Conclusion: Spindle cell carcinoma of the breast is a rare aggressive histological type of carcinoma which may present with benign features on imaging. Tissue diagnosis is essential for prompt diagnosis with multidisciplinary team discussion to guide management and improve patient’s outcome.

Radiologic Findings of a Rare Subtype of Invasive Breast Cancer with Poor Prognosis: Metaplastic Carcinoma of the Breast

2019 ◽  
Vol 15 (3) ◽  
pp. 338-348
Author(s):  
Hale Aydin ◽  
Bahar Guner ◽  
Isil Esen Bostanci ◽  
Nazan Ciledag ◽  
Melda Boyacioglu Bulut ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Multimodality Imaging ◽  
Metaplastic Carcinoma ◽  
Imaging Features ◽  
Mri Findings ◽  
Radiologic Findings ◽  
Round Shape ◽  
Malignant Feature ◽  
Imaging Results ◽  
Metaplastic Breast Carcinoma

Background and Objectives: The purpose of this study was to evaluate the mammographic, sonographic and MRI findings of metaplastic breast carcinoma. Methods: In this retrospective review study, we analyzed the medical files of 9600 patients who were treated for invasive breast cancers. Clinical information, histopathologic and radiologic findings of 65 patients were included in this study. All existing radiologic images and medical reports were reviewed retrospectively. Thirty-three patients had MG, 58 patients had US and 7 patients had MRI imaging results. Results: Mammographically, the most frequent presentations of MPBC were round shape, microlobulated margin and high density masses. Calcifications with or without masses were not a frequent finding. The most common sonographic findings were round shape, partially indistinct angular margin, hypoechoic and heterogeneous echo patterns and no posterior feature masses. All lesions were presented as masses rather than non-mass enhancements on magnetic resonance imaging. Features of masses had more malignant feature on MRI than other modalities in all 7 patients. Conclusion: Metaplastic breast carcinoma is one of the rarest poorly differentiated invasive breast carcinomas. Interestingly, these aggressive tumors demonstrate benign or moderately malign features on imaging methods. This appearance of MPBC can cause it to be misdiagnosed as a benign breast lesion especially in young women. MPBC should be kept in mind in the differential diagnosis of large palpable breast masses. Therefore, follow-up at short intervals and/or multimodality imaging studies which include breast MRI are important for the diagnosis of MPBC.

scholarly journals Metaplastic Carcinoma of the Breast with Neuroectodermal Stromal Component

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Tibor Tot ◽  
Juan José Badani De La Parra ◽  
Leif Bergkvist
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Brain Metastases ◽  
Lymph Node Metastases ◽  
Metaplastic Carcinoma ◽  
Unique Case ◽  
Carcinoma Of The Breast ◽  
Stromal Component ◽  
Node Metastases ◽  
Metaplastic Breast Carcinoma

A unique case of metaplastic breast carcinoma with an epithelial component showing tumoral necrosis and neuroectodermal stromal component is described. The tumor grew rapidly and measured 9 cm at the time of diagnosis. No lymph node metastases were present. The disease progressed rapidly and the patient died two years after the diagnosis from a hemorrhage caused by brain metastases. The morphology and phenotype of the tumor are described in detail and the differential diagnostic options are discussed.

scholarly journals Clinicopathological profile of invasive ductal breast carcinoma in a government tertiary care center in eastern India

Biomedicine ◽  
2021 ◽  
Vol 40 (4) ◽  
pp. 502-506
Author(s):  
Mrityunjay Pal ◽  
Saugata Ray ◽  
Priyanka Rani ◽  
Gautam Prakash ◽  
Raju Gupta
Keyword(s):  
Breast Carcinoma ◽  
Rural Areas ◽  
Tertiary Care ◽  
Radical Mastectomy ◽  
High Grade ◽  
Breast Lump ◽  
Invasive Ductal Breast Carcinoma ◽  
Ductal Breast Carcinoma ◽  
The Mean ◽  
Grade Tumour

Introduction and Aim: There is an increasing incidence of breast cancer (BC) in our country. The study aimed to find out the demographic profile, clinical presentation, and management in patients treated for invasive ductal breast carcinoma (IDC) in a rural government teaching hospital and to study the association of sociodemographic factors with BC stage. Materials and Methods: The study retrospectively analyzed 100 IDC females treated at Midnapore medical college, West Bengal, India from January 2017 to December 2019. The study included female patients of all ages diagnosed with IDC who had undergone surgery. Male BC, bilateral BC, other pathological types of BC were excluded. Results: The mean age was 56.54±12.99 years. Sixty-seven cases were postmenopausal. Eighty-one cases were from rural areas. Seventy-three cases had education up to middle school. Eighty-six cases had a lower socioeconomic status. Ninety-eight cases had unilateral breast lump and only 2% had a nonpalpable breast lump. The left breast was more commonly involved. The mean tumour size was 4.33 cm. Ninety-eight cases underwent a modified radical mastectomy. Stage III was the most commonly observed BC and seen in 40 cases followed by stage II in 36 cases. Sixty-one cases had advanced BC. Liver metastasis was seen in 21cases. Sixty-nine cases had axillary node(ALN) positivity. Sixty-eight cases had lymphovascular emboli (LVE). High-grade tumour was seen in 77%. High-grade tumour was more common in young women. Seventy three cases of tumours were estrogen receptor-positive (ER+) while 66% progesterone receptor-positive (PR+). Eighteen cases were human epidermal growth factor 2 receptor-positive. Conclusion: High incidence of advanced BC is found in rural areas due to a lack of awareness and health infrastructure.

scholarly journals Metaplastic carcinoma breast (IDC and chondrosarcoma): a rare entity

2018 ◽  
Vol 5 (7) ◽  
pp. 2646
Author(s):  
Deepesh Kalra ◽  
Bhanu Kaushik ◽  
Shalu Gupta ◽  
Pradeep Tanwar ◽  
Sami Anwar Khan
Keyword(s):  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Radical Mastectomy ◽  
Metaplastic Carcinoma ◽  
Ki 67 ◽  
Mucinous Component ◽  
Infiltrating Ductal Carcinoma ◽  
Characteristic Features ◽  
The Right ◽  
Metaplastic Breast Carcinoma

Metaplastic breast carcinoma is very rare neoplasm. Authors report a case of metaplastic breast carcinoma containing characteristic features of infiltrating ductal carcinoma and chondrosarcoma. A 62-year-old female presented with complaint of a lump in the right breast for the last 2 years. FNAC was suggestive of mucinous tumour. Tru-cut biopsy had been performed outside the institution, which was suggestive of a Ductal carcinoma with mucinous component. Modified radical mastectomy of the right breast was performed and histopathology was suggestive of infiltrating ductal carcinoma and chondrosarcoma of the right breast. All resected lymph nodes were free of metastasis. Immunohistochemistry was suggestive of a metaplastic carcinoma with components of ductal carcinoma and chondrosarcoma with moderately positive ER, negative PR, positive Pancytokeratin in ductal carcinoma component, positive S-100 and KI-67.

scholarly journals Metaplastic Carcinoma of the Breast with Squamous Differentiation: A Case Report from the University Teaching Hospital of Kigali (CHUK), Rwanda

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Delphine Uwamariya ◽  
Carine Nyampinga ◽  
Anne Yvette Nsenguwera ◽  
Belson Rugwizangoga
Keyword(s):  
Triple Negative ◽  
Large Mass ◽  
University Teaching ◽  
Metaplastic Carcinoma ◽  
Squamous Cells ◽  
Spindle Cells ◽  
The University ◽  
Neoplastic Epithelium ◽  
Metaplastic Breast Carcinoma ◽  
Breast Malignancies

Metaplastic breast carcinoma is a rare and aggressive condition, accounting less than 1% of breast malignancies. It presents with large mass and frequently with distant metastasis at time of diagnosis. Morphologically, it is characterized by the differentiation of neoplastic epithelium into epithelial or mesenchymal-looking elements like squamous cells, spindle cells, cartilage, or bone and has poor prognosis with its triple negative status.

scholarly journals Fibromatosis-like spindle-cell metaplastic carcinoma of the breast – a case report

2021 ◽  
Vol 19 (1) ◽  
pp. 98-101
Author(s):  
Michał Osuchowski ◽  
◽  
Dorota Bartusik-Aebisher ◽  
Ewa Kaznowska ◽  
David Aebisher ◽  
...  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Literature Review ◽  
Female Patient ◽  
Spindle Cell ◽  
Metaplastic Carcinoma ◽  
Diagnostic Challenge ◽  
Carcinoma Of The Breast ◽  
Mesenchymal Tissue ◽  
Metaplastic Breast Carcinoma

Introduction. Metaplastic breast carcinoma is expressing epithelial and/or mesenchymal tissue within the same tumor. Aim. The aim of this study is to evaluate metaplastic breast carcinoma in a case report and literature review. Description of the case. The presented case desribes metaplastic carcinoma of the breast in 65 years old female patient. Conclusion. Fibromatosis-cell metaplastic carcinoma of the breast presents a particularly large diagnostic challenge. Malignant variants of this disease have been described in the literature.

scholarly journals Metaplastic breast carcinoma with chondrosarcomatous differentiation: an unusual disease with a worse prognosis

2020 ◽  
Vol 7 (4) ◽  
pp. 1277
Author(s):  
Samuel Lalhruaizela ◽  
Bhupendra Mehra
Keyword(s):  
Breast Carcinoma ◽  
World Health ◽  
Metaplastic Carcinoma ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Duct Carcinoma ◽  
Increased Risk ◽  
Chondroid Metaplasia ◽  
Worse Prognosis ◽  
Metaplastic Breast Carcinoma

Metaplastic breast carcinoma (MBC) has an incidence of <1% of all breast cancers and MBC with chondrosarcomatous differentiation is even more rare, <0.1% of all cases. The World Health Organization have classified MBC into pure epithelial-type and mixed epithelial and mesenchymal type. The epithelial-type MBC is sub-classified into squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma with spindle cell differentiation; mixed type MBC is sub-classified into carcinosarcoma and carcinoma with osseous and chondroid metaplasia. Metaplastic carcinomas of the breast are characterized by large tumour size and rapid  growth, and they are usually estrogen receptor, progesterone receptor, and HER2/neu negative and tend to have a worse prognosis than other triple negative breast cancers. There is a noteworthy increased risk of tumour recurrence and a worse prognosis with MBC compared with invasive lobular carcinoma and infiltrating duct carcinoma. We report a case of metaplastic carcinoma with extensive chondroid differentiation that is chondrosarcoma and chondroid metaplasia along with classic infiltrating duct carcinoma with involvement of ipsilateral axillary lymph nodes.

scholarly journals Metaplastic Breast Carcinoma: Update on Histopathology and Molecular Alterations

2019 ◽  
Vol 143 (12) ◽  
pp. 1492-1496 ◽  
Author(s):  
Emily R. McMullen ◽  
Nicholas A. Zoumberos ◽  
Celina G. Kleer
Keyword(s):  
Differential Diagnosis ◽  
Breast Carcinoma ◽  
Gene Mutations ◽  
World Health ◽  
Metaplastic Carcinoma ◽  
Molecular Alterations ◽  
New Genes ◽  
Pathway Gene ◽  
Health Organization ◽  
Metaplastic Breast Carcinoma

Context— Metaplastic carcinoma is a rare, triple-negative carcinoma of the breast that exhibits transformation of part or all of its glandular carcinomatous component into a nonglandular, or metaplastic, component. The World Health Organization currently recognizes 5 variants of metaplastic carcinoma based on their histologic appearance. Objective— To review the histologic classifications, differential diagnosis, prognosis, and recent laboratory studies of metaplastic breast carcinoma. Data Sources.— We reviewed recently published studies that collectively examine metaplastic carcinomas, including results from our own research. Conclusions.— Metaplastic breast carcinoma has a broad spectrum of histologic patterns, often leading to a broad differential diagnosis. Diagnosis can typically be rendered by a combination of morphology and immunohistochemical staining for high-molecular-weight cytokeratins and p63. Recent studies elucidate new genes and pathways involved in the pathogenesis of metaplastic carcinoma, including the downregulation of CCN6 and WNT pathway gene mutations, and provide a novel MMTV-Cre;Ccn6fl/fl knockout disease-relevant mouse model to test new therapies.

scholarly journals Metaplastic Carcinoma of Breast: A Rare Pathological Entity- A Study of 10 Cases from Tertiary Care Centre in Northern India

2021 ◽  
Author(s):  
Monika B Gathwal ◽  
Chiranjeev Kumar Gathwal ◽  
Ruchi Agarwal ◽  
Swaran Kaur Saluja ◽  
Kulwant Singh ◽  
...  
Keyword(s):  
Triple Negative ◽  
Ductal Carcinoma ◽  
Tertiary Care ◽  
Radical Mastectomy ◽  
Metaplastic Carcinoma ◽  
Breast Cancers ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Mesenchymal Differentiation ◽  
The Mean

Introduction: Metaplastic Carcinoma of Breast (MCB) is a rare heterogeneous neoplasm characterised by a mixture of adenocarcinoma with dominant areas of spindle cells, squamous and other mesenchymal differentiation. The reported incidence is 0.2% of all breast cancers. Aim: To study the clinicopathological profile of MCB. Materials and Methods: This retrospective cross-sectional descriptive study included 10 cases of MCB who underwent mastectomy and biopsies at BPS GMC Khanpur Kalan, Sonipat, Haryana, India from March 2013 to February 2020. Results: Out of 10 cases, five cases were MCB Not Otherwise Specified (NOS) type, four cases were MCB with mesenchymal differentiation and one case showed rhabdomyosarcomatous differentiation. The right breast was involved in nine cases. The mean size of tumour was 8 cm with range of 3 to 16 cm. Five patients were treated by modified radical mastectomy and axillary dissection, four patients had lumpectomy and one patient underwent mastectomy. Half of the patients were below 40 years with the mean age being 36.8 years and range of 21-60 years. On Immunohistochemistry (IHC), 90% (9/10) cases were triple negative. Conclusion: MCB, although rare has to be diagnosed and excised at the earliest as the prognosis is predicted to be worse similar to other triple negative breast carcinomas. Ductal Carcinoma in Situ (DCIS) at the tumour periphery and co-expression of vimentin and cytokeratin would help to clinch the diagnosis in difficult situations.

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