scholarly journals Is the Post-Radical Prostatectomy Gleason Score a Valid Predictor of Mortality after Neoadjuvant Hormonal Treatment?

2015 ◽  
Vol 96 (3) ◽  
pp. 302-308
Author(s):  
Michael Froehner ◽  
Stefan Propping ◽  
Rainer Koch ◽  
Angelika Borkowetz ◽  
Dorothea Liebeheim ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Hormonal Treatment ◽  
Valid Predictor

Phase III results of adjuvant radiotherapy (RT) versus wait-and-see (WS) in patients with pT3 prostate cancer following radical prostatectomy (RP)(ARO 96–02/AUO AP 09/95)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 5060-5060 ◽  
Author(s):  
T. Wiegel ◽  
D. Bottke ◽  
N. Willich ◽  
H. Piechota ◽  
A. Siegmann ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Side Effects ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Adjuvant Radiotherapy ◽  
Progressive Disease ◽  
Hormonal Treatment ◽  
Tumor Stage ◽  
Phase Iii ◽  
Phase Iii Study

5060 Background: Adjuvant RT for pT3 R1 or R0 patients (pts.) after RP remains controversial. Results of an EORTC-phase-III- study (with unknown PSA-status after RP) suggested a 20% better biochemical control (bNED) after 5 years for RT. Methods: 385 men with prostate cancer were randomized to either 60 Gy RT (arm A; n=193) or WS (arm B; n=192) before achieving an undetectable PSA. Pts. were stratified for Gleason-score, margin status, neoadjuvant hormonal treatment and stage (pT3A+B vs. C). When the undetectable PSA-level after RP was not achieved, the pts. were stated as progressive disease and left arm A/B and were irradiated. PSA-progression for pts. with undetectable PSA was stated after two consecutive increasing PSA out of the undetectable range. Primary endpoint was bNED. Study was powered to demonstrate a 15% increase in bNED for RT. Results: 78 pts. (20%) did not achieve an undetectable PSA and were stated as progressive disease (arm A: 45 pts., arm B: 33 pts.). Additionally, 34 pts. (23%) from the RT-arm did not receive RT. Therefore, 114 pts. had RT (arm A) and 159 pts. WS (arm B). Median follow up was 53.6 months for arm A and 53.7 months for arm B. BNED at 5 years increased to 72% for arm A (RT) compared with 54% for arm B (WS) (p=0.0015, hazard ratio 0.53). Pts. with a preop. PSA > 10 ng/ml, tumor stage =pT3b, Gleason score =8 as well as positive margins profited significantly from adjuvant RT. The rate of late grade II side effects for the rectum was 1%. Conclusions: Adjuvant radiotherapy for pT3 prostate cancer significantly reduces the risk of biochemical progression after radical prostatectomy. The rate of side effects is very low. No significant financial relationships to disclose.

1607: Gleason Score Migration between Prostate Biopsy and Radical Prostatectomy Specimens

2005 ◽  
Vol 173 (4S) ◽  
pp. 435-435 ◽  
Author(s):  
Manish A. Vira ◽  
John E. Tomaszewski ◽  
Anthony V. D'Amico ◽  
Keith VanArsdalen ◽  
Alan J. Wein ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Prostate Biopsy

Importance of Reporting the Gleason Score at the Positive Surgical Margin Site: Analysis of 4,082 Consecutive Radical Prostatectomy Cases

2016 ◽  
Vol 195 (2) ◽  
pp. 337-342 ◽  
Author(s):  
Max Kates ◽  
Nikolai A. Sopko ◽  
Misop Han ◽  
Alan W. Partin ◽  
Jonathan I. Epstein
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Surgical Margin ◽  
Positive Surgical Margin ◽  
Site Analysis

scholarly journals Is Small Prostate Volume a Predictor of Gleason Score Upgrading after Radical Prostatectomy?

2013 ◽  
Vol 54 (4) ◽  
pp. 902 ◽  
Author(s):  
Mun Su Chung ◽  
Seung Hwan Lee ◽  
Dong Hoon Lee ◽  
Byung Ha Chung
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Prostate Volume

Use of the Prostate Health Index for the Detection of Aggressive Prostate Cancer at Radical Prostatectomy

2015 ◽  
Vol 95 (4) ◽  
pp. 390-399 ◽  
Author(s):  
Luigi Mearini ◽  
Elisabetta Nunzi ◽  
Carla Ferri ◽  
Guido Bellezza ◽  
Carolina Lolli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Health Index ◽  
Final Pathology ◽  
High Risk Disease ◽  
Prostate Health Index ◽  
Prostate Health

Introduction: In current study, we compared the accuracy of the PSA isoform p2PSA and its derivatives, the percentage of p2PSA to free PSA (%p2PSA) and the Prostate Health Index (PHI) in the detection of prostate cancer (PC) characteristics at the final pathology with respect to reference standards. Materials and Methods: This was an observational prospective study evaluating 43 consecutive PC patients treated with laparoscopic/robotic radical prostatectomy (RP). Logistic regression models were fitted to test the predictors of pT3 stage, pathologic Gleason score ≥8 or Gleason score upgrading, margin status, lymph node invasion, and the presence of high-risk disease (pT3 disease and/or Gleason score ≥8 and/or positive lymph node). The comparative base model included tPSA, clinical stage, biopsy Gleason score, and percentage of positive core. Results: Seventeen patients (39.5%) were affected by pT3 disease or had a pathologic Gleason score ≥8; positive margins were detected in 12 patients (27.9%), lymph node invasion was found in 2 patients (4.7%), and 15 patients (34.8%) harbored high-risk disease. In the univariate analysis, p2PSA, %p2PSA, and PHI were significant predictors of pT3 disease, pathologic Gleason score, and the presence of high-risk disease (all p < 0.05), whereas only PHI was an independent predictor of pT3 disease, margin status, and presence of high-risk disease, increasing the accuracy of a base multivariable model by 6.3% (p < 0.05) and 4.2% (p < 0.05) for the prediction of pT3 and high-risk disease, respectively. Conclusions: p2PSA and its derivatives, primarily PHI, were significant predictors of unfavorable PC characteristics as detected at the final pathology, thus improving the clinical performance of standard prognostic factors for aggressive disease.

scholarly journals Factors Related to Biochemical Relapse in Patients Undergoing Radical Prostatectomy with Lymphadenectomy.

2019 ◽  
Vol 2 (1) ◽  
pp. 01-04
Author(s):  
Grimar de Oliveira Paula ◽  
João Emerson de Alencar Santos ◽  
Luiz Carlos de Araújo Souza
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Clinical Stage ◽  
Surgical Specimen ◽  
Pathological Staging ◽  
Bcr Method ◽  
Transrectal Prostate Biopsy ◽  
Age Range

Objectives - Analyze the prevalence of biochemical recurrence (BCR) in patients submitted to radical prostatectomy with lymphadenectomy (RP-LD) the most prevalent clinical and pathological staging in the BCR and to correlate the sum of the Gleason score (GS) in the surgical specimen in patients who presented BCR. Method - Analysis of 100 patients diagnosed with prostate adenocarcinoma who performed RP-LD between 2013 to 2017. All subjects underwent transrectal prostate biopsy due to PSA or rectal examination and RP-LD. The lymphadenectomy considered in the study was the iliac-obturator, and the surgical pieces were analyzed to determine the pathological staging and its descriptors. All patients who had two or more PSA measurements >0.2 ng/ml and who had undergone RP-LD were considered postoperative. Results -About 22% of the patients submitted to RP-LD presented BCR. Patients with BCR had a 59-76 age range, mean age of 66.27 years, and median age of 63.50 years. The most prevalent preoperative PSA in patients with BCR was between 10-20 ng/ml (40.90%) and the most prevalent clinical stage was cT2 (59.10%). Regarding the Gleason score, the BCR patients had the most prevalent 6 (36.37%) score in the biopsy and score 7 (4 + 3) (36.37%) in the surgical specimen. All patients (100%) with BCR presented perineural invasion, with pT3 staging (81.81%) and pN0 (77.28%) being the most prevalent in patients with BCR. Patients with BCR presented a correlation (p<0.05) between the increase in the sum of pathological GS and the increase in pTN staging. Conclusion - All these variables were important in the determination of BCR in patients submitted to RP-LD, thus demonstrating the importance of this information in the analysis of the prognosis and in the follow-up of these patients.

Impact of the percentage of positive biopsy cores on the further stratification of primary grade 3 and grade 4 Gleason score 7 tumors in radical prostatectomy patients

Urology ◽  
2005 ◽  
Vol 66 (5) ◽  
pp. 1015-1019 ◽  
Author(s):  
Manish A. Vira ◽  
John E. Tomaszewski ◽  
Wei-Ting Hwang ◽  
Anthony V. D’Amico ◽  
Richard Whittington ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Gleason Score ◽  
Primary Grade ◽  
Positive Biopsy ◽  
Grade 3
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