Beta-Cell Replacement: Pancreas and Islet Cell Transplantation

2016 ◽  
pp. 146-162 ◽  
Author(s):  
Nadja Niclauss ◽  
Raphael Meier ◽  
Beno�t B�dat ◽  
Ekaterine Berishvili ◽  
Thierry Berney
Keyword(s):  
Beta Cell ◽  
Cell Transplantation ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
Cell Replacement ◽  
Beta Cell Replacement

scholarly journals Inflammatory Response in Islet Transplantation

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Mazhar A. Kanak ◽  
Morihito Takita ◽  
Faisal Kunnathodi ◽  
Michael C. Lawrence ◽  
Marlon F. Levy ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Cell Transplantation ◽  
Islet Transplantation ◽  
Islet Cell ◽  
Molecular Mechanisms ◽  
Graft Loss ◽  
Islet Cell Transplantation ◽  
Beta Cell Replacement ◽  
Insulin Dependent ◽  
Islet Inflammation

Islet cell transplantation is a promising beta cell replacement therapy for patients with brittle type 1 diabetes as well as refractory chronic pancreatitis. Despite the vast advancements made in this field, challenges still remain in achieving high frequency and long-term successful transplant outcomes. Here we review recent advances in understanding the role of inflammation in islet transplantation and development of strategies to prevent damage to islets from inflammation. The inflammatory response associated with islets has been recognized as the primary cause of early damage to islets and graft loss after transplantation. Details on cell signaling pathways in islets triggered by cytokines and harmful inflammatory events during pancreas procurement, pancreas preservation, islet isolation, and islet infusion are presented. Robust control of pre- and peritransplant islet inflammation could improve posttransplant islet survival and in turn enhance the benefits of islet cell transplantation for patients who are insulin dependent. We discuss several potent anti-inflammatory strategies that show promise for improving islet engraftment. Further understanding of molecular mechanisms involved in the inflammatory response will provide the basis for developing potent therapeutic strategies for enhancing the quality and success of islet transplantation.

Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice

Diabetes ◽  
1992 ◽  
Vol 41 (12) ◽  
pp. 1672-1676 ◽  
Author(s):  
I. C. Gerling ◽  
D. V. Serreze ◽  
S. W. Christianson ◽  
E. H. Leiter
Keyword(s):  
Beta Cell ◽  
Cell Transplantation ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
Beta Cell Autoimmunity

scholarly journals P.113: The Role of Necroptosis in Beta-cell Loss Following Islet Cell Transplantation

2021 ◽  
Vol 105 (12S1) ◽  
pp. S42-S42
Author(s):  
Saloni Aggarwal ◽  
Sandra Kelly ◽  
Joy Paramor ◽  
Karen Seeberger ◽  
Mandy Rosko ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Transplantation ◽  
Islet Cell ◽  
Cell Loss ◽  
Islet Cell Transplantation

Islet cell transplantation for the treatment of type 1 diabetes in the USA

2008 ◽  
Vol 16 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Tetsuya Ikemoto ◽  
Hirofumi Noguchi ◽  
Masayuki Shimoda ◽  
Bashoo Naziruddin ◽  
Andrew Jackson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cell Transplantation ◽  
Islet Cell ◽  
Islet Cell Transplantation ◽  
The Usa
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