Human Chorionic Gonadotropin Stimulation Test in Prepubertal Children with Micropenis Can Accurately Predict Leydig Cell Function in Pubertal or Postpubertal Adolescents

2015 ◽  
Vol 84 (5) ◽  
pp. 305-310 ◽  
Author(s):  
Tomohiro Ishii ◽  
Nobutake Matsuo ◽  
Seiji Sato ◽  
Tsutomu Ogata ◽  
Shinya Tamai ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Leydig Cell ◽  
Human Chorionic Gonadotropin ◽  
Cell Function ◽  
Stimulation Test ◽  
Prepubertal Children ◽  
Gonadotropin Stimulation ◽  
Leydig Cell Function

The Effects of Chronic Human Chorionic Gonadotropin Treatment on Leydig Cell Function*

Endocrinology ◽  
1982 ◽  
Vol 110 (1) ◽  
pp. 138-145 ◽  
Author(s):  
G. P. RISBRIDGER ◽  
D. M. ROBERTSON ◽  
D. M. DE KRETSER
Keyword(s):  
Chorionic Gonadotropin ◽  
Leydig Cell ◽  
Human Chorionic Gonadotropin ◽  
Cell Function ◽  
Leydig Cell Function

scholarly journals Evaluation of endocrine testing of Leydig cell function using extractive and recombinant human chorionic gonadotropin and different doses of recombinant human LH in normal men

2008 ◽  
Vol 159 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Anne Cailleux-Bounacer ◽  
Yves Reznik ◽  
Bruno Cauliez ◽  
Jean François Menard ◽  
Céline Duparc ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Leydig Cell ◽  
Cell Function ◽  
Dose Effect ◽  
Plasma Testosterone ◽  
Testosterone Levels ◽  
Plasma Estradiol ◽  
Normal Men ◽  
Dose Dependent ◽  
Leydig Cell Function

BackgroundThe functional testing of endocrine testis uses extractive human chorionic gonadotropin (ehCG). Recombinant human hCG (rhCG), avoiding any contamination, should replace ehCG. Moreover, a functional evaluation with recombinant human LH (rhLH) would be closer to physiology than a pharmacological testing with hCG.MethodsThe study was conducted in normal men. We first evaluated the dose–effect of ehCG on plasma testosterone and estradiol levels, before and after injection of either hCG or vehicle. Secondly, the responses to the optimal dose of ehCG were compared with those of rhCG. Thirdly, we investigated the dose–effect of rhLH, on steroid hormone secretion. LH, testosterone, and estradiol plasma levels were measured after the injection of either rhLH or placebo.ResultsehCG induced dose-dependent increases in plasma estradiol and testosterone levels. They respectively peaked at 24 and 72 h after the injection. The most potent dose of ehCG (5000 IU) induced results similar to those observed with 250 μg (6500 IU) rhCG. By comparison with placebo, rhLH induced a significant and dose-dependent increase in plasma testosterone levels 4 h after the injection. Peak response of testosterone to rhLH and rhCG was significantly correlated. rhLH did not induce significant change in plasma estradiol level.ConclusionsIn normal men, a single i.v. injection of 150 IU rhLH induces a 25% rise in plasma testosterone levels by comparison with placebo. At the moment, the dynamic evaluation using hCG remains the gold standard test to explore the Leydig cell function. The use of 250 μg rhCG avoiding any contamination should be recommended.

scholarly journals Endocrine Profiles in Pediatric Andrology III. Human Chorionic Gonadotropin Stimulation Test in Cryptorchid Boys

1983 ◽  
Vol 11 (1) ◽  
pp. 53-58 ◽  
Author(s):  
E. S. E. Hafez ◽  
I. M. Ghaly ◽  
I. I. Ibrahim ◽  
O. El-rouby ◽  
M. I. Abdalla ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Stimulation Test ◽  
Gonadotropin Stimulation ◽  
Endocrine Profiles

Low-dose Human Chorionic Gonadotropin Stimulation Test as a Prognostic Incontinent Indicator in Boys With Bladder Exstrophy-epispadias Complex

Urology ◽  
2017 ◽  
Vol 101 ◽  
pp. 133-138 ◽  
Author(s):  
Nastaran Sabetkish ◽  
Sahar Eftekharzadeh ◽  
Azadeh Elmi ◽  
Saman Shafaat Talab ◽  
Abdol-Mohammad Kajbafzadeh
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Low Dose ◽  
Bladder Exstrophy ◽  
Stimulation Test ◽  
Gonadotropin Stimulation
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