scholarly journals A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study

2015 ◽  
Vol 45 (2) ◽  
pp. 90-99 ◽  
Author(s):  
Maria Donata Benedetti ◽  
Maura Pugliatti ◽  
Roberto D''Alessandro ◽  
Ettore Beghi ◽  
Adriano Chiò ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Rate Ratio ◽  
Telephone Survey ◽  
Clinical Manifestations ◽  
Guillain Barre Syndrome ◽  
Annual Incidence Rate ◽  
Italian Studies ◽  
Italian Regions ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Background: To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

Influenza vaccination and Guillain Barre syndrome☆

2003 ◽  
Vol 107 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Mark R. Geier ◽  
David A. Geier ◽  
Arthur C. Zahalsky
Keyword(s):  
Influenza Vaccination ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

OVERLAP NEUROLOGICAL SYNDROMES ASSOCIATED WITH ANTIBODIES TO GLUTAMIC ACID DECARBOXYLASE: CLINICAL OBSERVATION

2021 ◽  
Vol 100 (2) ◽  
pp. 284-287
Author(s):  
E.S. Druzhinina ◽  
◽  
R.T. Bembeeva ◽  
D.S. Druzhinin ◽  
U.M. Azizova ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Clinical Observation ◽  
Clinical Manifestations ◽  
Overlap Syndrome ◽  
Guillain Barre Syndrome ◽  
Acid Decarboxylase ◽  
Pediatric Practice ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

The article presents a description of an overlap syndrome, rare in pediatric practice, associated with antibodies to glutamic acid decarboxylase in a 4-year-old child, which was initially regarded as a variant of Guillain–Barré syndrome due to the similarity of clinical manifestations.

Guillain-Barré Syndrome

2019 ◽  
pp. 193-207
Author(s):  
Matthew J. G. Burford ◽  
Richard A. Lewis
Keyword(s):  
Differential Diagnosis ◽  
Immune Therapy ◽  
Treatment Options ◽  
General Pattern ◽  
Clinical Manifestations ◽  
Sudden Onset ◽  
Guillain Barre Syndrome ◽  
Clinical Scenario ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

This chapter begins by outlining the origin of Guillain-Barré syndrome (GBS). It looks at the epidemiology and antecedent events. It also considers clinical manifestations. The classic clinical scenario is one of acute, symmetric, progressive, ascending weakness, and areflexia, with or without sensory symptoms days to weeks after a preceding infection. Next differential diagnosis is examined. The differential diagnosis of GBS is quite broad and includes disorders leading to sudden onset of weakness. The general pattern of clinical involvement and medical history helps to hone the differential. Finally, the chapter looks at management of the syndrome and treatment options for various different groups, such as immune therapy.

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