scholarly journals Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients

2015 ◽  
Vol 167 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Hui-Ying Wang ◽  
Zhong-Shan Gao ◽  
Xiang Zhou ◽  
Yu Dai ◽  
Wo Yao ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Dust Mite ◽  
Der P 1 ◽  
Der P 2

Role of Der p 1–specific B cells in immune tolerance during 2 years of house dust mite–specific immunotherapy

2019 ◽  
Vol 143 (3) ◽  
pp. 1077-1086.e10 ◽  
Author(s):  
Tadech Boonpiyathad ◽  
Willem van de Veen ◽  
Oliver Wirz ◽  
Milena Sokolowska ◽  
Beate Rückert ◽  
...  
Keyword(s):  
B Cells ◽  
Immune Tolerance ◽  
House Dust ◽  
House Dust Mite ◽  
Specific Immunotherapy ◽  
Dust Mite ◽  
Der P 1

Sequence polymorphisms of Der f 1, Der p 1, Der f 2 and Der p 2 from Korean house dust mite isolates

2012 ◽  
Vol 58 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Kyoung Yong Jeong ◽  
In-Yong Lee ◽  
Tai-Soon Yong ◽  
Jae-Hyun Lee ◽  
Eun-Jin Kim ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Dust Mite ◽  
Sequence Polymorphisms ◽  
Der P 1 ◽  
Der P 2

Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2

2008 ◽  
Vol 45 (5) ◽  
pp. 1308-1317 ◽  
Author(s):  
Krisztina Szalai ◽  
Jan Fuhrmann ◽  
Tea Pavkov ◽  
Michael Scheidl ◽  
Julia Wallmann ◽  
...  
Keyword(s):  
B Cell ◽  
House Dust ◽  
House Dust Mite ◽  
B Cell Epitopes ◽  
Dust Mite ◽  
Der P 1 ◽  
Der P 2

scholarly journals Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy

2012 ◽  
Vol 130 (2) ◽  
pp. 435-443.e4 ◽  
Author(s):  
Kuan-Wei Chen ◽  
Katharina Blatt ◽  
Wayne R. Thomas ◽  
Ines Swoboda ◽  
Peter Valent ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Combination Vaccines ◽  
Dust Mite ◽  
Der P 1 ◽  
Der P 2

scholarly journals IgE Abs to Der p 1 and Der p 2 as diagnostic markers of house dust mite allergy as defined by a bronchoprovocation test

2015 ◽  
Vol 64 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Takafumi Minami ◽  
Yuma Fukutomi ◽  
Jonas Lidholm ◽  
Hiroshi Yasueda ◽  
Akemi Saito ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Diagnostic Markers ◽  
House Dust Mite Allergy ◽  
Mite Allergy ◽  
Dust Mite ◽  
Der P 1 ◽  
Der P 2

scholarly journals Der p 1 Disrupts the Epithelial Barrier and Induces IL-6 Production in Patients With House Dust Mite Allergic Rhinitis

2021 ◽  
Vol 2 ◽  
Author(s):  
Kazuhiro Ogi ◽  
Mahnaz Ramezanpour ◽  
Sha Liu ◽  
Jannatul Ferdoush Tuli ◽  
Catherine Bennett ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
House Dust ◽  
House Dust Mite ◽  
Paracellular Permeability ◽  
Epithelial Barrier ◽  
Dependent Manner ◽  
Dust Mite ◽  
Der P1 ◽  
Der P 1 ◽  
Der P 2

Background:Dermatophagoides pteronyssinus 1/2 (Der p 1/Der p 2) are regarded as important allergens of house dust mite (HDM). However, the effect of both products on the epithelial barrier and immune response of patients with and without HDM allergic rhinitis (AR) remains unclear.Methods: Air–liquid interface (ALI) cultured human nasal epithelial cells (HNECs) derived from control subjects (non-AR) (n = 9) and HDM-AR patients (n = 9) were treated with Der P 1 and Der P 2, followed by testing the transepithelial electrical resistance (TEER), paracellular permeability of fluorescein isothiocyanate (FITC)-dextrans and immunofluorescence of claudin-1 and ZO-1. Interleukin-6 (IL-6) production was evaluated by ELISA.Results: Der p 1 reduced TEER significantly in a transient and dose-dependent manner in HNEC-ALI cultures from HDM-AR and non-AR patients, whilst the paracellular permeability was not affected. TEER was significantly reduced by Der p 1 at the 10-min time point in HDM-AR patients compared to non-AR patients (p = 0.0259). Compared to no-treatment control, in HNECs derived from HDM-AR patients, Der p 1 significantly cleaved claudin-1 after 30 min exposure (72.7 ± 9.5 % in non-AR group, 39.9 ± 7.1 % in HDM-AR group, p = 0.0286) and induced IL-6 secretion (p = 0.0271).Conclusions: Our results suggest that patients with HDM-AR are more sensitive to Der p 1 than non-AR patients with increased effects of Der p1 on the mucosal barrier and induction of inflammation, indicating an important role for Der p1 in sensitization and HDM-AR development.

Engineering of major house dust mite allergens Der p 1 and Der p 2 for allergen-specific immunotherapy

2009 ◽  
Vol 39 (7) ◽  
pp. 1088-1098 ◽  
Author(s):  
J. A. Asturias ◽  
I. Ibarrola ◽  
M. C. Arilla ◽  
C. Vidal ◽  
A. Ferrer ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Specific Immunotherapy ◽  
Allergen Specific Immunotherapy ◽  
Dust Mite ◽  
Der P 1 ◽  
Der P 2

scholarly journals Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice

2012 ◽  
Vol 21 (11) ◽  
pp. 842-846 ◽  
Author(s):  
Krisztina Szalai ◽  
Tamara Kopp ◽  
Anna Lukschal ◽  
Caroline Stremnitzer ◽  
Julia Wallmann ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Dust Mite ◽  
Der P 1 ◽  
Der P 2
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