scholarly journals Bench Test for the Detection of Bacterial Contamination in Platelet Concentrates Using Rapid and Cultural Detection Methods with a Standardized Proficiency Panel

2015 ◽  
Vol 42 (4) ◽  
pp. 220-225 ◽  
Author(s):  
Tanja Vollmer ◽  
Cornelius Knabbe ◽  
Wolf-Jochen Geilenkeuser ◽  
Michael Schmidt ◽  
Jens Dreier
Keyword(s):  
Bacterial Contamination ◽  
Detection Methods ◽  
Bench Test ◽  
Platelet Concentrates ◽  
Proficiency Panel

Bacterial contamination of platelet concentrates prepared by different methods: results of standardized sterility testing in Germany

Vox Sanguinis ◽  
2006 ◽  
Vol 90 (3) ◽  
pp. 177-182 ◽  
Author(s):  
G. Walther-Wenke ◽  
R. Doerner ◽  
Th. Montag ◽  
O. Greiss ◽  
B. Hornei ◽  
...  
Keyword(s):  
Bacterial Contamination ◽  
Platelet Concentrates ◽  
Sterility Testing

scholarly journals Atypical Bacterial Growth within Units of Platelets Challenges Transfusion Medicine Dogma

2018 ◽  
Vol 56 (12) ◽  
Author(s):  
Eric A. Gehrie
Keyword(s):  
Bacterial Contamination ◽  
Current Issue ◽  
Safety Concern ◽  
Positive Culture ◽  
Storage Period ◽  
Transfusion Medicine ◽  
Platelet Concentrates ◽  
Content Type ◽  
Platelet Storage ◽  
Positive Culture Result

ABSTRACT Although transfusion-transmitted bacterial infection is relatively rare, mitigation of bacterial contamination of platelet units is arguably the top current transfusion-related safety concern. Several different technologies have been employed to detect or neutralize bacteria in platelet concentrates. However, studies of the efficacy of these systems have been hampered by problematic definitions of what represents a “true-positive” versus a “false-positive” culture result. In the current issue of the Journal of Clinical Microbiology (M. Cloutier, M.-È. Nolin, H. Daoud, A. Jacques, M. J. de Grandmont, É Ducas, G. Delage, and L. Thibault, J Clin Microbiol 56:e01105-18, 2018, https://doi.org/10.1128/JCM.01105-18), it was demonstrated that the growth of Bordetella holmesii is inhibited by the platelet storage environment, which may explain why the results of initial positive platelet cultures are not always confirmed by subsequent cultures later during the storage period. This important finding is at odds with the generally held belief within the field of transfusion medicine that initially positive platelet cultures that are not confirmed on repeat testing are instrumentation-based false positives. The clinical risk profile of organisms demonstrating storage-related low viability is worthy of further study.

Bacterial contamination of platelet concentrates: results of a prospective multicenter study comparing pooled whole blood?derived platelets and apheresis platelets

Transfusion ◽  
2007 ◽  
Vol 47 (4) ◽  
pp. 644-652 ◽  
Author(s):  
Hubert Schrezenmeier ◽  
Gabriele Walther-Wenke ◽  
Thomas H. Müller ◽  
Franz Weinauer ◽  
Adelheid Younis ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Whole Blood ◽  
Bacterial Contamination ◽  
Platelet Concentrates ◽  
Prospective Multicenter Study ◽  
Apheresis Platelets

Frequency of bacterial contamination of platelet concentrates before and after introduction of diversion method in Japan

Transfusion ◽  
2009 ◽  
Vol 49 (10) ◽  
pp. 2152-2157 ◽  
Author(s):  
Masahiro Satake ◽  
Takako Mitani ◽  
Shinji Oikawa ◽  
Hideto Nagumo ◽  
Sayoko Sugiura ◽  
...  
Keyword(s):  
Bacterial Contamination ◽  
Platelet Concentrates ◽  
Before And After
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