scholarly journals Mixed Adenoneuroendocrine Carcinoma of the Stomach

2015 ◽  
Vol 9 (2) ◽  
pp. 241-245 ◽  
Author(s):  
Ching-Ming Kwok
Keyword(s):  
Local Recurrence ◽  
Total Gastrectomy ◽  
Who Classification ◽  
Rare Condition ◽  
Gastric Tumor ◽  
Endocrine Tumors ◽  
Review Of The Literature ◽  
Carcinoma Of The Stomach ◽  
Mixed Adenoneuroendocrine Carcinoma

Mixed adenoneuroendocrine carcinoma is a rare condition comprising at least 30% of each component of exocrine and endocrine tumors. The denominations were defined in the 2000 WHO classification of endocrine tumors. We report an 83-year-old male with a polypoid gastric tumor in the gastric high body who received total gastrectomy and died 8 months after the diagnosis from local recurrence and distal metastases. A review of the literature for this infrequent condition is presented.

scholarly journals A Rare Case of Mixed Ductal Neuroendocrine Tumor of the Pancreas

2021 ◽  
Vol 8 (2) ◽  
pp. C20-24
Author(s):  
Vidya Viswanathan ◽  
Harsh Kumar ◽  
Charusheela Gore ◽  
Shrikant Kurhade ◽  
Rumaanah Khan
Keyword(s):  
Neuroendocrine Tumour ◽  
Rare Condition ◽  
Collision Tumor ◽  
Definitive Diagnosis ◽  
Anatomical Site ◽  
Endocrine Tumors ◽  
Microscopic Features ◽  
To Come ◽  
Adenocarcinoma Component

Collision tumors are tumors that have at least two types of tumors in the same anatomical site with no area of mixing within the transition zone. In 2010 WHO classification of neuroendocrine tumors consists of an adenocarcinoma component and a neuroendocrine carcinoma component in which each of the components accounts for 30% of the tumor. Such tumors are defined as mixed adenoneuroendocrine carcinomas. Occurrence of exocrine and endocrine tumors of the pancreas is extremely rare. The aim of our study was to describe a case in a 60 years old male who was diagnosed with this rare tumor. Gross, microscopic features and immunohistochemistry were used to diagnose this rare condition. Immunohistochemistry markers such as synaptophysin, chromogranin, EMA and Pan CK were used to come to a definitive diagnosis. Synaptophysin and chromogranin were found to be positive in the neuroendocrine component. EMA and Pan CK were found to be positive in the ductal component. Hence a diagnosis of mixed ductal neuroendocrine tumour (collision tumor) was made.

Cholesteatoma of the external auditory canal in hemifacial hypertrophy (hyperplasia)

1989 ◽  
Vol 103 (1) ◽  
pp. 74-78 ◽  
Author(s):  
Arun K. Gadre ◽  
K. C. Gadre
Keyword(s):  
External Auditory Canal ◽  
Site Selection ◽  
Rare Condition ◽  
Review Of The Literature ◽  
Selection Of

AbstractCongenital hemifacial hypertrophy is an extremely rare condition. At the time of writing this article, there have been 37 cases reported in the literature. Of these, only two have appeared in the otolaryngologic literature. Cholesteatoma of the external auditory canal (EAC) in hemifacial hypertrophy has not been reported before. This article reports one such case, and discusses the classification of hemihypertrophies. A review of the literature is included in the discussion. Management of cholesteatomas of the external auditory canal is also touched upon. A new theory for the peculiar site selection of cholesteatomas of the external auditory canal is postulated.

Primary Umbilical Adenocarcinoma: Case Report and Review of the Literature

2007 ◽  
Vol 73 (9) ◽  
pp. 923-925 ◽  
Author(s):  
Olcay Alver ◽  
Yeliz E. Ersoy ◽  
Gulen Dogusoy ◽  
Sabri Erguney
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Local Recurrence ◽  
Hepatic Metastases ◽  
Rare Condition ◽  
Primary Adenocarcinoma ◽  
Review Of The Literature ◽  
Short Time

Primary adenocarcinoma arising at the umbilicus is a very rare condition. The umbilicus has been found to show a wide variety of tumors and is predisposed to metastases from visceral tumors because of its relationships and generous vascular and embryologic connections. Herein, we describe a case of a primary umbilical adenocarcinoma with short time survival related to local recurrence and multiple hepatic metastases 6 months after her surgical treatment.

scholarly journals Primary Cutaneous Follicle Center Lymphoma of the Eyelid: A Case Report and Review of the Literature in Light of Recent Changes to the WHO Classification of Lymphoid Neoplasms

2018 ◽  
Vol 5 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Astrid C. Werner ◽  
Nora V. Laver ◽  
Dan S. Landmann
Keyword(s):  
Case Report ◽  
Who Classification ◽  
Clinical Stage ◽  
Survival Rates ◽  
Review Of The Literature ◽  
Systemic Involvement ◽  
Lymphoid Neoplasms ◽  
Cutaneous Lymphomas ◽  
Histopathologic Features

Primary cutaneous follicle center lymphoma (PCFCL) is a unique entity that represents up to 11% of all cutaneous lymphomas. PCFCL is associated with an indolent course and excellent 5-year survival rates, but can progress to secondary systemic involvement if left untreated. Histopathologic features of PCFCL can vary depending on the size, duration, and clinical stage of the lesion, making diagnosis somewhat challenging. Here, we present a case of a 50-year-old woman with an eyelid lesion that was initially classified as an inflamed cyst based on biopsy, but 1 year later, was determined to be PCFCL after repeat biopsy revealed different histology. In light of the recent changes to the WHO classification of lymphoid neoplasms, we review the unique clinical and histopathologic features of PCFCL that distinguish it from other more aggressive forms of cutaneous lymphoma in terms of course, prognosis, and management.

scholarly journals Ameloblastic Fibrosarcoma of the Mandible

1969 ◽  
Vol 33 (1) ◽  
pp. 58-60
Author(s):  
Jennifer T. Go ◽  
Jose M. Carnate
Keyword(s):  
Case Report ◽  
Who Classification ◽  
International Agency ◽  
Review Of The Literature ◽  
Patient Age ◽  
Epithelial Component ◽  
Patient Âgé ◽  
Ameloblastic Fibroma ◽  
Ameloblastic Fibrosarcoma

A 32-year old Filipino woman presented with a 3-year history of slowly enlarging left hemimandibular mass with no associated symptoms. Previous biopsy showed ameloblastoma. Imaging revealed a translucent mulitloculated mass with ill-defined borders. (Figure 1) On examination, the mass was irregularly shaped, measures 40 x 39 cm, slightly hyperpigmented and erythematous, warm with visible vessels. The patient underwent left segmental mandibulectomy with reconstruction and the specimen was sent for histopathologic evaluation.   Received was a mandibulectomy specimen weighing 1850 grams and measuring 17 x 14.5 x 14 cm. The body, angle, ramus and condyles of the left hemimandible are no longer identifiable grossly. There are ten teeth attached. Cut sections show multiple cystic spaces which measure from 0.8 to 15.0 cm in widest diameter, filled with abundant red-brown necrotic debris and yellow-brown purulent material. The mass has a grey-tan soft to fibrous cut surface with focal gritty areas. (Figure 2)   Microscopic examination shows a biphasic neoplasm composed of benign epithelial and malignant mesenchymal components. (Figure 3) The benign epithelial component is arranged in islands and strands with peripheral palisading, composed of bland cells without atypia. (Figure 4) The abundant mesenchymal component is composed of spindle cells in fascicles. The cells are moderately pleomorphic with enlarged hyperchromatic nuclei, prominent nucleoli, coarse chromatin and scant cytoplasm. The cells are suspended within loose stroma with variable degree of cellularity. Some mitoses are noted. (Figure 5)   Ameloblastic fibrosarcoma (AFS) belongs to a group of odontogenic sarcomas in which the epithelial component is cytologically benign while the ectomesenchymal component shows malignant features. The AFS is the most common type among the odontogenic sarcomas. It is regarded as the malignant counterpart of ameloblastic fibroma (AF). Although most cases arise de novo, the documentation of a prior or pre-existing precursor lesion from ameloblastic fibroma suggests otherwise.1,2 A study by Kobayashi et al. suggested that up to one-third of AFS arise from AF while a review of literature by Lai et al. demonstrated that 51% of AFS had previously documented AF at the same site, providing supporting evidence of a malignant transformation.3   Ameloblastic fibrosarcoma has a reported age range of 3 - 89 years, with overall mean patient age of 27.3 years. In cases of prior diagnosis of AF, AFS can occur at a mean patient age of 33 years whereas a mean patient age of 23 years where no prior diagnosis of AF was documented.1,4 It mainly affects males in the third or fourth decade of life and the posterior mandible is the most commonly affected site, with ratio of mandibular to maxillary incidence of 4:1.1,3,4  The clinical presentation is usually that of a painful, enlarging mass and most lesions are radiographically translucent and multiloculated with ill-defined borders.2,4   The histologic features of AFS reveal a mixture of benign odontogenic epithelium ranging from budding and branching cords to large islands composed of columnar or cuboidal peripheral cells arranged in palisading pattern, and an abundant malignant mesenchymal component showing marked cellularity, nuclear pleomorphism, and moderate mitotic figures.1,2,3 Ameloblastic fibroma differs from AFS by having no malignant component and immunohistochemical stains have been suggested to provide distinction, particularly when identifying a low-grade fibrosarcoma. The malignant component of AFS will show positivity in p53 and PCNA and will have a higher Ki-67 expression than AF.3,4   Although AFS are low to intermediate-grade sarcomas, a high incidence of recurrence is reported - about one third of patients experience recurrence and overall mortality rate is 25%. However, only less than 5% of cases with metastases have been reported.1,3 Long term follow up is thus indicated.   References             Wright JM. Odontogenic Sarcomas. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO Classification of Head and Neck Tumours, WHO Classification of Tumours, 4th Edition, Volume 9. Lyon: International Agency for Research on Cancer IARC; 2017, p. 214.   Servato JPS, De Faria PR, Ribeiro CV, Cardoso SV, Dias FL, Eisenberg ALA, Loyola AM. Ameloblastic fibrosarcoma: a case report and literature review. Braz Dent J 2017 Mar-Apr; 28(2):262-272. DOI: 1590/0103-6440201701050 PMID: 28492759   Loya-Solis A. Gonzalez-Colunga KJ, Perez-Rodriguez CM, Ramirez-Ochoa NS, Cecenas-Falcon L, Barboza-Quintana O. Ameloblastic fibrosarcoma of the mandible: a case report and brief review of the literature. Case Rep Pathol. 2015;2015:245026. Epub 2015 Mar 10 DOI: 1155/2015/245026 PMID: 25861504 PMCID: PMC4377457   Al Shetawi AH, Alpert EH, Buchbinder D, Urken ML. Ameloblastic fibrosarcoma of the mandible: a case report and a review of the literature. J Oral Maxillofac Surg 2015 Aug;73(8):1661.e1-7. Epub 2015 Apr 10. DOI: 1016/j.joms.2015.03.066 PMID: 25921823                

scholarly journals Gliosarcomas: A Rare Case Report at Viet Duc University Hospital and Review of the Literature

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Nguyen Thi Quynh ◽  
Nguyen Duc Hoan ◽  
Dao Thi Luan ◽  
Nguyen Tung Ngoc ◽  
Nguyen Sy Lanh
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Who Classification ◽  
Biological Behavior ◽  
International Agency ◽  
Review Of The Literature ◽  
The Central Nervous System ◽  
The Brain

Gliosarcoma is a rare biphasic subtype of glioblastoma with the poor prognosis, principally affects adults; males are more frequently affected, with a male-to-female ratio of 1.8/1. Gliosarcomas are usually located in the cerebral hemispheres, involving the temporal, frontal, parietal, and occipital lobes in decreasing order of frequency. Rarely, gliosarcomas occur in the posterior fossa, lateral ventricles, or spinal cord. A case study: A 32-year-old woman presented with persistent nausea and headache. The preoperative diagnosis was Ependymoma in the right lateral ventricle of the brain. The patient underwent surgical resection of the tumor followed by external radiotherapy, and chemotherapy treatment. Histologic description: The tumor was made up of spindle cells with hyperchromic large nuclei and pink cytoplasm intermingled with large cells with markedly pleomorphic nuclei and abundant cytoplasm along with prominent mitotic activity. Tumour cells revealed positive staining for Ki67 (25%), Oligo2 (focal), GFAP (focal), SMA (focal); negative immunoreactivity for EMA, CD34, Bcl-2, TTF1. Pathological diagnosis: Gliosarcoma, grade IV. Conclusions: Gliosarcoma is an extremely rare neoplasm with an aggressive biological behavior. In terms of histopathology, gliosarcomas are characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation.   Keywords Gliosarcoma, glioblastoma multiforme, brain neoplasm. References [1] World Healh Organization, WHO Classification of Tumors of the Central Nervous System, International Agency for Research on Cancer (IARC) 69372 Lyon Cedex 08, France, 2016. [2] F. A. Hashmi, A. Salim, M. Shamim, M. Bari, Biological Characteristics and Outcomes of Gliosarcoma, The Journal of the Pakistan Medical Association, Vol. 68, No. 8, 2018, pp. 1273-1275. [3] P. Giglio, M. R. Gilbert, Encyclopedia of the Neurological Sciences (Second Edition), MA: Academic Press/Elsevier, Waltham, 2014. [4] R. K. Kevin, M. Anand, S. M. John, Adult Gliosarcoma: Epidemiology, Natural History, and Factors Associated with Outcome, Neuro Oncol, Vol. 11, No. 2, 2009, pp. 183-191, https://doi.org/10.1215/15228517-2008-076. [5] L. Han, X. Zhang, S. Qiu et al., Magnetic Resonance Imaging of Primary Cerebral Gliosarcoma: A Report of 15 Cases, Acta Radiologica, Vol. 49, No.9, 2008, pp. 1058-1067, doi:10.1080/02841850802314796. [6] D. N. Louis, H. Ohgaki, O. D. Wiestler et al., The 2007 WHO Classification of Tumours of the Central Nervous System, Acta Neuropathologica, Vol. 114, No. 2, 2007, pp. 97-109, doi:10.1007/s00401-007-0278-6. [7] L. Seth, P. Arie, I. James et al., Greenfield’s Neuropathology (Ninth Edition), CRC Press, Boca Raton, Florida, 2015. [8] L. Cervoni, P. Celli, Cerebral Gliosarcoma: Prognostic Factors, Neurosurgical Review, Vol. 19, No. 2, 1996, pp. 93-96, https://doi.org/10.1007/bf00418077. [9] J. Pardo, M. Murcia, G. Felip et al., Gliosarcoma: A Rare Primary CNS Tumor. Presentation of Two Cases, Reports of Practical Oncology & Radiotherapy, Vol. 15, No. 4, 2010, pp. 98-102, https://doi.org/10.1016/j.rpor.2010.05.003. [10] J. Lutterbach, R. Guttenberger, A. Pagenstecher, Gliosarcoma: A Clinical Study, Radiotherapy andOncology, Vol. 61, No. 1, 2001, pp. 57-64,https://doi.org/10.1016/S0167-8140(01)00415-7. [11] B. K. Kleinschmidt, T. Tihan, F. Rodriguez, Diagnostic Pathology: Neuropathology (Second Edition), Elsevier, Philadelphia, 2016. [12] H. F. Irwin, W. G. Sidney, Sarcoma Arising in Glioblastoma of the Brain, Am J Pathol, Vol. 31, No. 4, 1955, pp. 633-653. [13] A. S. Awadalla, A. M. A. Essa, H. H. A. Ahmadi et al., Gliosarcoma Case Report and Review of the Literature, The Pan African Medical Journal, Vol. 35, No. 26, 2020, https://doi.org/10.3109/02841869709001353.        

scholarly journals Erythromelanosis Follicularis Faciei et Colli: A Case Report in a Caucasian Male and Brief Review of the Literature

2020 ◽  
Vol 12 (3) ◽  
pp. 231-235
Author(s):  
Carl Maximilian Thielmann ◽  
Wiebke Sondermann
Keyword(s):  
Case Report ◽  
Family History ◽  
Clinical Presentation ◽  
Rare Condition ◽  
Unknown Etiology ◽  
Review Of The Literature ◽  
Caucasian Male

Erythromelanosis follicularis faciei et colli, a rare condition of unknown etiology, was first described by Kitamura et al. from Japan in 1960. It is characterized by a triad consisting of well-demarcated erythema, hyperpigmentation, and follicular papules. We report the case of a 50-year-old Caucasian male, who had asymptomatic symmetrical facial lesions since the age of 42. His family history was unremarkable. Published erythromelanosis follicularis faciei et colli cases of the last 10 years are summarized in this report to demonstrate the variability and differences in the clinical presentation of this uncommon diagnosis.

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