Occult Tumor Cells in Lymph Nodes of Patients with Gastric Cancer: A Systematic Review on Their Prevalence and Predictive Role

Oncology ◽  
2015 ◽  
Vol 89 (5) ◽  
pp. 245-254 ◽  
Author(s):  
Amelia Tavares ◽  
Matilde Monteiro-Soares ◽  
Fernando Viveiros ◽  
Jorge Maciel Barbosa ◽  
Mário Dinis-Ribeiro
Keyword(s):  
Gastric Cancer ◽  
Systematic Review ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Occult Tumor ◽  
Predictive Role ◽  
Occult Tumor Cells

Clinical Relevance of Occult Tumor Cells in Lymph Nodes From Gastric Cancer Patients

2005 ◽  
Vol 29 (9) ◽  
pp. 1135-1144 ◽  
Author(s):  
Fania S Doekhie ◽  
Wilma E Mesker ◽  
J Han J. M. van Krieken ◽  
Niels F. M Kok ◽  
Henk H Hartgrink ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Clinical Relevance ◽  
Occult Tumor ◽  
Gastric Cancer Patients ◽  
Occult Tumor Cells

scholarly journals DETECTION OF OCCULT LYMPH NODE TUMOR CELLS IN NODE-NEGATIVE GASTRIC CANCER PATIENTS

2017 ◽  
Vol 30 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Marina Alessandra PEREIRA ◽  
Marcus Fernando Kodama Pertille RAMOS ◽  
Andre Roncon DIAS ◽  
Osmar Kenji YAGI ◽  
Sheila Friedrich FARAJ ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Node Negative ◽  
Occult Tumor ◽  
Increased Risk ◽  
Gastric Cancer Patients ◽  
Occult Tumor Cells

ABSTRACT Background: The presence of lymph nodes metastasis is one of the most important prognostic indicators in gastric cancer. The micrometastases have been studied as prognostic factor in gastric cancer, which are related to decrease overall survival and increased risk of recurrence. However, their identification is limited by conventional methodology, since they can be overlooked after routine staining. Aim: To investigate the presence of occult tumor cells using cytokeratin (CK) AE1/AE3 immunostaining in gastric cancer patients histologically lymph node negative (pN0) by H&E. Methods: Forty patients (T1-T4N0) submitted to a potentially curative gastrectomy with D2 lymphadenectomy were evaluated. The results for metastases, micrometastases and isolated tumor cells were also associated to clinicopathological characteristics and their impact on stage grouping. Tumor deposits within lymph nodes were defined according to the tumor-node-metastases guidelines (7th TNM). Results: A total of 1439 lymph nodes were obtained (~36 per patient). Tumor cells were detected by immunohistochemistry in 24 lymph nodes from 12 patients (30%). Neoplasic cells were detected as a single or cluster tumor cells. Tumor (p=0.002), venous (p=0.016), lymphatic (p=0.006) and perineural invasions (p=0.04), as well as peritumoral lymphocytic response (p=0.012) were correlated to CK-positive immunostaining tumor cells in originally negative lymph nodes by H&E. The histologic stage of two patients was upstaged from stage IB to stage IIA. Four of the 28 CK-negative patients (14.3%) and three among 12 CK-positive patients (25%) had disease recurrence (p=0.65). Conclusion: The CK-immunostaining is an effective method for detecting occult tumor cells in lymph nodes and may be recommended to precisely determine tumor stage. It may be useful as supplement to H&E routine to provide better pathological staging.

Methylation-Specific PCR for DNA-Based Detection of Occult Tumor Cells in Lymph Nodes of Prostate Cancer Patients

2003 ◽  
Vol 44 (5) ◽  
pp. 533-538 ◽  
Author(s):  
Jens Köllermann ◽  
Markus Müller ◽  
Carsten Goessl ◽  
Hans Krause ◽  
Burkhard Helpap ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Occult Tumor ◽  
Methylation Specific Pcr ◽  
Specific Pcr ◽  
Occult Tumor Cells

scholarly journals OCCULT TUMOR CELLS IN LYMPH NODES AS A PREDICTOR FOR TUMOR RELAPSE IN PANCREATIC CANCER

Pancreas ◽  
2005 ◽  
Vol 31 (4) ◽  
pp. 467
Author(s):  
P Scheunemann ◽  
N H Stoecklein ◽  
A Rehders ◽  
M Bidde ◽  
P E Verde ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Lymph Nodes ◽  
Tumor Cells ◽  
Tumor Relapse ◽  
Occult Tumor ◽  
Occult Tumor Cells

Prognostic relevance of occult tumor cells in lymph nodes of colorectal carcinomas

1997 ◽  
Vol 40 (12) ◽  
pp. 1465-1471 ◽  
Author(s):  
Rainer Broll ◽  
Verena Schauer ◽  
Hendrik Schimmelpenning ◽  
Martin Strik ◽  
Alexander Woltmann ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Tumor Cells ◽  
Colorectal Carcinomas ◽  
Occult Tumor ◽  
Prognostic Relevance ◽  
Occult Tumor Cells

Occult tumor cells in lymph nodes as a predictor for tumor relapse in pancreatic adenocarcinoma

2007 ◽  
Vol 393 (3) ◽  
pp. 359-365 ◽  
Author(s):  
Peter Scheunemann ◽  
Nikolas H. Stoecklein ◽  
Alexander Rehders ◽  
Minu Bidde ◽  
Sylvia Metz ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Tumor Cells ◽  
Pancreatic Adenocarcinoma ◽  
Tumor Relapse ◽  
Occult Tumor ◽  
Occult Tumor Cells
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