scholarly journals Characterization of the Genotypic Profile of Hepatitis Delta Virus: Isolation of HDV Genotype-1 in the Western Amazon Region of Brazil

Intervirology ◽  
2015 ◽  
Vol 58 (3) ◽  
pp. 166-171 ◽  
Author(s):  
Luan Felipo Botelho-Souza ◽  
Deusilene Souza Vieira ◽  
Alcione de Oliveira dos Santos ◽  
André Vinycius Cunha Pereira ◽  
Juan Miguel Villalobos-Salcedo
Keyword(s):  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Clinical Characteristics ◽  
Amazon Region ◽  
Viral Envelope ◽  
Serum Samples ◽  
Hepatitis Delta ◽  
Pcr Rflp ◽  
Hdv Infection ◽  
Delta Virus

The hepatitis delta virus (HDV) is a hepatotropic subvirus that is dependent on the hepatitis B virus (HBV) and supplies the viral envelope containing the surface antigen of hepatitis B. Viral genetic diversity is related to the geographical origin of the isolates, and there are at least eight genotypes that are referred to as HDV-1 through HDV-8. HDV-3 is responsible for epidemics of severe and fulminant hepatitis, which are common in northeastern South America. HDV-3 is prevalent in the Brazilian Amazon and is associated with the increased aggressiveness of HDV infections. Although isolated, the characteristics of the clinical presentation of HDV-1 in the Amazon region have not yet been clearly reported. Objective: This study aims to assess the genotypic and clinical characteristics of individuals with the HDV-1 genotype in the western Amazon region. Methods: The HDV was genotyped by nested PCR-RFLP and sequencing from serum samples of 56 patients with HBV/HDV infection. The genotypes were correlated with the clinical characteristics presented by patients with HBV/HDV infection. Results: A prevalence of 92.3% for the HDV-3 genotype (n = 48) and 7.6% (n = 4) for the HDV-1 genotype was observed. Conclusion: To date, this is the most extensive clinical study of HDV-1 genotype infections in the nonindigenous population of Western Amazonia.

scholarly journals Prevalence of Hepatitis Delta Virus (HDV) Infection in Chronic Hepatitis B Patients with Unusual Clinical Pictures

2013 ◽  
Vol 13 (8) ◽  
Author(s):  
Shiva Ghamari ◽  
Seyed Moayed Alavian ◽  
Mario Rizzetto ◽  
Antonella Olivero ◽  
Antonina Smedile ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Hepatitis Delta ◽  
Hdv Infection ◽  
Clinical Pictures ◽  
Delta Virus

Hepatitis B virus and hepatitis delta virus subtypes circulating in Algeria and seroprevalence of HDV infection

2018 ◽  
Vol 91 (1) ◽  
pp. 72-80 ◽  
Author(s):  
Samir Gourari ◽  
Ségolène Brichler ◽  
Frédéric Le Gal ◽  
Mariama Abdou‐Chekaraou ◽  
Mohamed Amine Beloufa ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Hepatitis Delta ◽  
B Virus ◽  
Hdv Infection ◽  
Delta Virus

scholarly journals Prevalence of hepatitis delta virus among chronic hepatitis B carriers in a large tertiary center in the Netherlands

2021 ◽  
pp. 104870
Author(s):  
Boris J.B. Beudeker ◽  
Jolanda J.C. Voermans ◽  
Corine.H. GeurtsvanKessel ◽  
Robert J. de Knegt ◽  
Tamara Kuhlemann ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
The Netherlands ◽  
Chronic Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Hepatitis Delta ◽  
Tertiary Center ◽  
Delta Virus

scholarly journals Analysis of Multiple Liver Explant Pieces Reveals that Levels of Hepatitis Delta Virus RNA Are Independent of Hepatitis B Virus Expression

2021 ◽  
Author(s):  
Kasthuri Prakash ◽  
Simon B. Larsson ◽  
Gustaf E. Rydell ◽  
Johan Ringlander ◽  
Catarina Skoglund ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Hepatitis Delta ◽  
Virus Rna ◽  
B Virus ◽  
Virus Expression ◽  
Delta Virus

Occurrence of Hepatitis Delta Virus Infection in Hepatitis B Virus-Infected Patients with Different Serum Patterns of PreS Gene-Encoded Proteins

Digestion ◽  
1993 ◽  
Vol 54 (1) ◽  
pp. 9-14
Author(s):  
Nicola Napoli ◽  
Giorgio Fiore ◽  
Giacomo Fera ◽  
Angela Modugno ◽  
Gianluigi Giannelli ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Hepatitis Delta ◽  
Hepatitis Delta Virus Infection ◽  
B Virus ◽  
Encoded Proteins ◽  
Delta Virus

scholarly journals Delta hepatitis: molecular biology and clinical and epidemiological features.

1993 ◽  
Vol 6 (3) ◽  
pp. 211-229 ◽  
Author(s):  
L B Polish ◽  
M Gallagher ◽  
H A Fields ◽  
S C Hadler
Keyword(s):  
Liver Disease ◽  
High Risk ◽  
Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Hepatitis B Infection ◽  
Hepatitis Delta ◽  
Hepatitis Delta Virus Infection ◽  
B Virus ◽  
The World ◽  
Delta Virus

Hepatitis delta virus, discovered in 1977, requires the help of hepatitis B virus to replicate in hepatocytes and is an important cause of acute, fulminant, and chronic liver disease in many regions of the world. Because of the helper function of hepatitis delta virus, infection with it occurs either as a coinfection with hepatitis B or as a superinfection of a carrier of hepatitis B surface antigen. Although the mechanisms of transmission are similar to those of hepatitis B virus, the patterns of transmission of delta virus vary widely around the world. In regions of the world in which hepatitis delta virus infection is not endemic, the disease is confined to groups at high risk of acquiring hepatitis B infection and high-risk hepatitis B carriers. Because of the propensity of this viral infection to cause fulminant as well as chronic liver disease, continued incursion of hepatitis delta virus into areas of the world where persistent hepatitis B infection is endemic will have serious implications. Prevention depends on the widespread use of hepatitis B vaccine. This review focuses on the molecular biology and the clinical and epidemiologic features of this important viral infection.

scholarly journals Prevalence and genotype distribution of hepatitis delta virus among chronic hepatitis B carriers in Central Vietnam

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175304 ◽  
Author(s):  
Hung Minh Nguyen ◽  
Bui Tien Sy ◽  
Nguyen Thanh Trung ◽  
Nghiem Xuan Hoan ◽  
Heiner Wedemeyer ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis Delta Virus ◽  
Genotype Distribution ◽  
Hepatitis Delta ◽  
Central Vietnam ◽  
Delta Virus
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