Vancomycin Therapy of Staphylococcal Infections

2015 ◽  
pp. 84-96 ◽  
Author(s):  
William M. M. Kirby
Keyword(s):  
Vancomycin Therapy ◽  
Staphylococcal Infections

Vancomycin Therapy for Serious Staphylococcal Infections in Chronic Hemodialysis Patients

1980 ◽  
Vol 4 (4) ◽  
pp. 179-184 ◽  
Author(s):  
M. H. Bierman ◽  
C. A. Needham-Walker ◽  
M. Hammeke ◽  
J. D. Egan
Keyword(s):  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Vancomycin Therapy ◽  
Staphylococcal Infections

Effects of Vancomycin on Platelets, Plasma Proteins and Hepatitis B Surface Antigen

1975 ◽  
Vol 34 (01) ◽  
pp. 083-093 ◽  
Author(s):  
Barry S Coller ◽  
W. B Lundberg ◽  
Harvey R Gralnick
Keyword(s):  
Hepatitis B ◽  
Factor Viii ◽  
Surface Antigen ◽  
Plasma Proteins ◽  
Hepatitis B Surface Antigen ◽  
Infusion Site ◽  
Vancomycin Therapy ◽  
Intravenous Injections ◽  
Low Concentrations ◽  
High Doses

SummaryThe antibiotic vancomycin shares many similarities with ristocetin, an agent noted for its effects on platelets and plasma fibrinogen. Vancomycin did not aggregate platelets as ristocetin, but platelets were incorporated into precipitates induced by vancomycin. Fibrinogen and factor VIII were precipitated from plasma at low concentrations of vancomycin. The precipitated fibrinogen remained clottable. Hepatitis B surface antigen was selectively precipitated from serum and could be recovered from the precipitate. Rabbits receiving bolus intravenous injections of high doses of vancomycin developed hypofibrinogenemia and thrombocytopenia within minutes and often went on to die. Studies with 125I-vancomycin revealed little stable binding of the antibiotic to platelets or fibrinogen. A relationship is suggested between the potent protein precipitating effects and phlebitis at the infusion site commonly associated with vancomycin therapy.

scholarly journals An In Vitro Study of the Effect of Viburnum opulus Extracts on Key Processes in the Development of Staphylococcal Infections

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1758
Author(s):  
Urszula Wójcik-Bojek ◽  
Joanna Rywaniak ◽  
Przemysław Bernat ◽  
Anna Podsędek ◽  
Dominika Kajszczak ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Protein A ◽  
In Vitro Study ◽  
Alternative Methods ◽  
Staphylococcal Protein A ◽  
Viburnum Opulus ◽  
Staphylococcal Infections ◽  
Diet Supplements ◽  
Drug Resistant Strains

Staphylococcus aureus is still one of the leading causes of both hospital- and community-acquired infections. Due to the very high percentage of drug-resistant strains, the participation of drug-tolerant biofilms in pathological changes, and thus the limited number of effective antibiotics, there is an urgent need to search for alternative methods of prevention or treatment for S. aureus infections. In the present study, biochemically characterized (HPLC/UPLC–QTOF–MS) acetonic, ethanolic, and water extracts from fruits and bark of Viburnum opulus L. were tested in vitro as diet additives that potentially prevent staphylococcal infections. The impacts of V. opulus extracts on sortase A (SrtA) activity (Fluorimetric Assay), staphylococcal protein A (SpA) expression (FITC-labelled specific antibodies), the lipid composition of bacterial cell membranes (LC-MS/MS, GC/MS), and biofilm formation (LIVE/DEAD BacLight) were assessed. The cytotoxicity of V. opulus extracts to the human fibroblast line HFF-1 was also tested (MTT reduction). V. opulus extracts strongly inhibited SrtA activity and SpA expression, caused modifications of S. aureus cell membrane, limited biofilm formation by staphylococci, and were non-cytotoxic. Therefore, they have pro-health potential. Nevertheless, their usefulness as diet supplements that are beneficial for the prevention of staphylococcal infections should be confirmed in animal models in the future.

Staphylococcal infections and infertility: mechanisms and management

2020 ◽  
Vol 474 (1-2) ◽  
pp. 57-72
Author(s):  
Sulagna Dutta ◽  
Pallav Sengupta ◽  
Emmanuel Izuka ◽  
Ifeanyi Menuba ◽  
Ravindran Jegasothy ◽  
...  
Keyword(s):  
Staphylococcal Infections

422 ORAL VANCOMYCIN THERAPY IS ASSOCIATED WITH IBD CLINICAL REMISSION IN PEDIATRIC PSC-IBD

2021 ◽  
Vol 160 (6) ◽  
pp. S-88
Author(s):  
Amanda Ricciuto ◽  
Kuan Liu ◽  
Achiya Z. Amir ◽  
Madeleine Aumar ◽  
Annemarie Broderick ◽  
...  
Keyword(s):  
Clinical Remission ◽  
Oral Vancomycin ◽  
Vancomycin Therapy
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