Bilateral Renal Autotransplantation May Be an Effective and Definitive Treatment in Case of Loin Pain Haematuria Syndrome

2015 ◽  
Vol 99 (1) ◽  
pp. 118-120
Author(s):  
Félix Rohrer ◽  
Sebastien Déglise ◽  
Vincent Bettschart ◽  
Jan Schmidtko
Keyword(s):  
Pain Relief ◽  
Definitive Treatment ◽  
Therapeutic Approaches ◽  
Renal Autotransplantation ◽  
Loin Pain ◽  
Loin Pain Haematuria Syndrome

Loin pain haematuria (LPHS) is a rare and difficult-to-diagnose syndrome. Different therapeutic approaches have been used historically with little or no success. We report a case of LPHS in which bilateral renal autotransplantation led to pain relief, cessation of all medication and no recurrence beyond two years of follow-up.

STEREOTACTIC RADIOSURGERY FOR THE TREATMENT OF PRIMARY SARCOMAS AND SARCOMA METASTASES OF THE SPINE

Neurosurgery ◽  
2009 ◽  
Vol 64 (suppl_2) ◽  
pp. A54-A59 ◽  
Author(s):  
Alan M. Levine ◽  
Cardella Coleman ◽  
Sylvia Horasek
Keyword(s):  
Pain Relief ◽  
Stereotactic Radiosurgery ◽  
Tumor Regression ◽  
Spinal Metastasis ◽  
Definitive Treatment ◽  
Complete Tumor Regression ◽  
Institutional Review ◽  
Spinal Sarcoma ◽  
Complete Tumor

Abstract OBJECTIVE Spinal sarcomas pose unique treatment dilemmas because of the difficulty of achieving adequate surgical margins and/or delivering curative radiation doses (65 Gy) in close proximity to the spinal cord. This study used hypofractionated stereotactic radiosurgery (SRS) to deliver higher biologically effective doses to treat primary spinal sarcomas and spinal sarcoma metastases. METHODS Twenty-four patients with spinal or paraspinal sarcomas entered an Institutional Review Board-approved registry trial to evaluate SRS efficacy. They were assessed at regular intervals for pain control, disease progression, and complications for a minimum of 12 months or until death. RESULTS The median treatment dose for the spinal sarcoma lesions was 30 Gy at the 80% isodose in 3 fractions, with some variation based on tumor size, shape, and dose to adjacent critical structures. Seven patients were treated definitively; all had excellent pain relief and are alive with a mean follow-up period of 33 months. Two patients had complete tumor regression, 3 had partial regression, and 2 experienced recurrences and have been re-treated. Seven patients underwent resection and adjuvant SRS. One of 3 patients treated preoperatively had complete tumor regression, and none of the 4 patients treated postoperatively had a local recurrence with a mean follow-up period of 43.5 months. All 10 patients with sarcoma metastases to the spine (16 lesions) died, with a mean survival of 11.1 months from first spinal metastasis treatment. Complete pain relief was achieved in 8 patients, partial relief in 7 patients, and none in 1 patient. No patient developed radiation myelitis. CONCLUSION These preliminary results suggest that SRS may have a role in the definitive treatment of patients with primary spinal sarcomas who are deemed unresectable and as adjuvant treatment in those undergoing surgery and for palliation of sarcoma metastases.

Loin pain haematuria syndrome: distress resolved by pain relief

Pain ◽  
1998 ◽  
Vol 76 (1) ◽  
pp. 209-213 ◽  
Author(s):  
Matthew Bultitude ◽  
John Young ◽  
Michael Bultitude ◽  
James Allan
Keyword(s):  
Pain Relief ◽  
Loin Pain ◽  
Loin Pain Haematuria Syndrome

scholarly journals Ureteric bupivicaine infusion for loin pain haematuria syndrome

2010 ◽  
Vol 92 (2) ◽  
pp. 139-141 ◽  
Author(s):  
P Ahmed ◽  
P Acher ◽  
AM Deane
Keyword(s):  
Randomised Controlled Trial ◽  
Adverse Effects ◽  
Controlled Trial ◽  
Opiate Dependence ◽  
Ureteric Catheter ◽  
Loin Pain ◽  
Loin Pain Haematuria Syndrome ◽  
Randomised Controlled ◽  
Trial Setting

INTRODUCTION Loin pain haematuria syndrome is a common problem with complications including opiate dependence. Morbidity treatments include intra-ureteric capsaicin infusion, nephrectomy, autotransplantation and nephrolysis. We explored the use of flexible cystoscopic infusion of intra-ureteric bupivicaine. PATIENTS AND METHODS Patients presenting with chronic loin pain underwent urological and nephrological evaluation. Bupivicaine (0.5%, 20 ml) was infused via an intra-ureteric catheter under flexible cystoscopic guidance. Repeat infusions were offered if indicated. RESULTS Sixteen of 17 patients with 1-year follow-up responded and were satisfied. Twelve of these required repeat infusions (mean, 2.9 infusions). The procedures were well tolerated by all patients without adverse effects. CONCLUSIONS Intra-ureteric bupivicaine infusion has a place in the management of patients with chronic renal pain. It offers a minimally invasive alternative to other treatments. This procedure warrants further investigation within a randomised, controlled trial setting.

TREATMENT OF LOIN PAIN/HAEMATURIA SYNDROME BY RENAL AUTOTRANSPLANTATION

The Lancet ◽  
1987 ◽  
Vol 330 (8564) ◽  
pp. 907-908 ◽  
Author(s):  
A.G.R. Sheil ◽  
L.S. Ibels ◽  
Carol Pollock ◽  
J.C. Graham ◽  
J. Short
Keyword(s):  
Renal Autotransplantation ◽  
Loin Pain ◽  
Loin Pain Haematuria Syndrome

RECURRENCE OF LOIN PAIN/HAEMATURIA SYNDROME AFTER RENAL AUTOTRANSPLANTATION

The Lancet ◽  
1987 ◽  
Vol 329 (8548) ◽  
pp. 1501-1502 ◽  
Author(s):  
StephenM.W. Hutchison ◽  
Andrew Doig ◽  
ANDREWMcL. Jenkins
Keyword(s):  
Renal Autotransplantation ◽  
Loin Pain ◽  
Loin Pain Haematuria Syndrome

RENAL AUTOTRANSPLANTATION FOR SEVERE LOIN-PAIN/HAEMATURIA SYNDROME

The Lancet ◽  
1985 ◽  
Vol 326 (8466) ◽  
pp. 1216-1217 ◽  
Author(s):  
A.G.R. Sheil ◽  
M.A.B. Thomas ◽  
L.S. Ibels ◽  
J.C. Graham
Keyword(s):  
Renal Autotransplantation ◽  
Loin Pain ◽  
Loin Pain Haematuria Syndrome

Recurrent graft pain following renal autotransplantation for loin pain haematuria syndrome

1996 ◽  
Vol 78 (1) ◽  
pp. 25-28 ◽  
Author(s):  
A.P. Parnham ◽  
A. Low ◽  
P. Finch ◽  
D. Perlman ◽  
M.A.B. Thomas
Keyword(s):  
Renal Autotransplantation ◽  
Loin Pain ◽  
Loin Pain Haematuria Syndrome

scholarly journals Spontaneous haemorrhage of an adrenal angiomyolipoma: case report

2019 ◽  
Vol 25 (1) ◽  
Author(s):  
Danielle Whiting ◽  
Ian Rudd ◽  
Amit Goel ◽  
Seshadri Sriprasad ◽  
Sanjeev Madaan
Keyword(s):  
Case Reports ◽  
Case Presentation ◽  
Open Adrenalectomy ◽  
Large Size ◽  
History Of ◽  
Loin Pain ◽  
Benign Tumours ◽  
Spontaneous Haemorrhage ◽  
Mesenchymal Tumours

Abstract Background Angiomyolipomas are rare mesenchymal tumours arising from the perivascular epithelioid cells consisting of variable amounts of adipose, thick-walled blood vessels and smooth muscle cells. These benign tumours commonly occur in the kidney with only a few case reports of adrenal angiomyolipomas which have the potential to reach a large size and haemorrhage. Case presentation A 45-year-old lady presented with a 3-week history of right loin pain, nausea and vomiting. A CT scan revealed a right adrenal angiomyolipoma measuring 6.3 × 6.8 cm with associated haemorrhage. The lesion was successfully treated with right open adrenalectomy, and histology confirmed the diagnosis of adrenal angiomyolipoma. The patient remained well with no evidence of recurrence at the 36-month follow-up. Conclusion Adrenal angiomyolipomas are rare benign tumours that have the ability to reach a large size and potential to bleed. Here, we report the second case of spontaneous haemorrhage in an adrenal angiomyolipoma, which was successfully treated with open adrenalectomy.

scholarly journals Various Therapeutic Methods for the Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ) and Their Limitations: A Narrative Review on New Molecular and Cellular Therapeutic Approaches

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 680
Author(s):  
Sung-Woon On ◽  
Seoung-Won Cho ◽  
Soo-Hwan Byun ◽  
Byoung-Eun Yang
Keyword(s):  
Bone Morphogenetic Proteins ◽  
Maxillofacial Surgery ◽  
Treatment Protocol ◽  
Osteonecrosis Of The Jaw ◽  
Therapeutic Modality ◽  
Definitive Treatment ◽  
Antiangiogenic Agents ◽  
Platelet Concentrates ◽  
Therapeutic Approaches ◽  
Positive Effect

Medication-related osteonecrosis of the jaw (MRONJ) is one of the most interesting diseases in the field of maxillofacial surgery. In addition to bisphosphonates, the use of antiresorptive and antiangiogenic agents is known to be the leading cause. However, the exact pathogenesis of MRONJ has not been established, and various hypotheses have been proposed, such as oxidative stress-related theory. As a result, a definitive treatment protocol for MRONJ has not been identified, while various therapeutic approaches are applied to manage patients with MRONJ. Although the surgical approach to treat osteomyelitis of the jaw has been proven to be most effective, there are limitations, such as recurrence and delayed healing. Many studies and clinical trials are being conducted to develop another effective therapeutic modality. The use of some materials, including platelet concentrates and bone morphogenetic proteins, showed a positive effect on MRONJ. Among them, teriparatide is currently the most promising material, and it has shown encouraging results when applied to patients with MRONJ. Furthermore, cell therapy using mesenchymal stem cells showed promising results, and it can be the new therapeutic approach for the treatment of MRONJ. This review presents various treatment methods for MRONJ and their limitations while investigating newly developed and researched molecular and cellular therapeutic approaches along with a literature review.

Sign in / Sign up

Export Citation Format

Share Document