Clinico-Pathological Correlations of the Frontal Lobe Syndrome: Results of a Large Brain Bank Study

2015 ◽  
Vol 40 (3-4) ◽  
pp. 121-129
Author(s):  
Welmoed A. Krudop ◽  
Sjanne Bosman ◽  
Jeroen J.G. Geurts ◽  
Sietske A.M. Sikkes ◽  
Nicolaas A. Verwey ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Grey Matter ◽  
Pathological Changes ◽  
Brain Bank ◽  
Large Brain ◽  
Cortical Pathology ◽  
Brain Changes ◽  
Subcortical Regions ◽  
Frontal Lobe Syndrome ◽  
First Time

Aims: A clinical frontal lobe syndrome (FLS) is generally attributed to functional or structural disturbances within frontal-subcortical circuits. We studied the distribution of pathological brain changes in FLS. Additionally, the prevalence of FLS among various disorders was studied. Methods: We systematically screened clinical files of donors to the Netherlands Brain Bank (n = 2,814) for FLS. A total of 262 FLS cases were identified, and the distribution of postmortem pathological changes within the frontal-subcortical circuits was extracted from their neuropathological reports. Results: In 244 out of 262 patients (93%), pathological changes within the frontal-subcortical circuits were found: 90 subjects (34%) with frontal cortical pathology and 18 (7%) with pathology restricted to subcortical grey matter nuclei, whereas 136 subjects (52%) showed both cortical and subcortical pathology. In 18 subjects (7%), no pathology was found in the examined areas. The prevalence of FLS was highest in frontal-temporal lobar degeneration, followed by progressive supranuclear palsy and vascular dementia [χ2(6, n = 1,561) = 222.64, p < 0.01]. Conclusion: In this large brain bank study, the distribution of pathological changes in subjects with FLS was shown to be frontal-subcortical for the first time. A minority of FLS cases had pathology in the subcortical regions only or no frontal pathology at all.

O4-05-02: Clinicopathological correlations of the frontal lobe syndrome: Results of a large brain bank study

2012 ◽  
Vol 8 (4S_Part_17) ◽  
pp. P623-P623
Author(s):  
Sjanne Bosman ◽  
Jeroen Geurts ◽  
Welmoed Krudop ◽  
Wouter Kamphorst ◽  
Annemieke Rozemuller ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Brain Bank ◽  
Large Brain ◽  
Clinicopathological Correlations ◽  
Frontal Lobe Syndrome

Structural and metabolic cerebral alterations between elderly bipolar disorder and behavioural variant frontotemporal dementia: A combined MRI-PET study

2018 ◽  
Vol 53 (5) ◽  
pp. 413-423 ◽  
Author(s):  
Giuseppe Delvecchio ◽  
Gian Mario Mandolini ◽  
Andrea Arighi ◽  
Cecilia Prunas ◽  
Carlo Massimo Mauri ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Prefrontal Cortex ◽  
Frontotemporal Dementia ◽  
Grey Matter ◽  
Temporal Cortex ◽  
Positron Emission ◽  
Dorsolateral Prefrontal ◽  
Magnetic Resonance Imaging Mri ◽  
Subcortical Regions ◽  
First Time

Background: Elderly bipolar disorder (BD) and behavioural variant of frontotemporal dementia (bvFTD) may exhibit similar symptoms and both disorders are characterized by selective abnormalities in cortical and subcortical regions that are associated with cognitive and emotional impairments. We aimed to investigate common and distinct neural substrates of BD and bvFTD by coupling, for the first time, magnetic resonance imaging (MRI) and positron emission tomography (PET) techniques. Methods: 3-Tesla MRI and 18 fluorodeoxyglucose–PET scans were acquired for 16 elderly BD patients, 23 bvFTD patients with mild cognitive impairments and 68 healthy controls (48 for PET and 20 for MRI analyses). Results: BD and bvFTD patients exhibit a different localization of grey matter reductions in the lateral prefrontal cortex, with the first group showing grey matter decrease in the ventrolateral prefrontal cortex and the latter group showing grey matter reductions in the dorsolateral prefrontal cortex as well as unique grey matter and metabolic alterations within the orbitofrontal cortex. The bvFTD group also displayed unique volumetric shrinkage in regions within the temporo-parietal network together with greater metabolic impairments within the temporal cortex and more extensive volumetric and metabolic abnormalities within the limbic lobe. Finally, while the BD group showed greater grey matter volumes in caudate nucleus, bvFTD subjects displayed lower metabolism. Conclusion: This MRI-PET study explored, for the first time to the best of our knowledge, structural and functional abnormalities in bvFTD and elderly BD patients, with the final aim of identifying the specific biological signature of these disorders, which might have important implications not only in prevention but also in differential diagnosis and treatment.

Structural brain changes in tinnitus: grey matter decrease in auditory and non-auditory brain areas

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
M Landgrebe ◽  
K Rosengarth ◽  
A Koch ◽  
T Kleinjung ◽  
A May ◽  
...  
Keyword(s):  
Grey Matter ◽  
Brain Areas ◽  
Brain Changes ◽  
Structural Brain

scholarly journals Concurrent Inverted Papilloma and Squamous Cell Carcinoma with Intradural Extension Presenting with Frontal Lobe Syndrome

2021 ◽  
Author(s):  
Abdul Jaleel ◽  
Pavithran V. M. ◽  
Shanavas Cholakkal ◽  
Vineeth Kadangot Kuthampulli
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Frontal Lobe ◽  
Squamous Cell ◽  
Benign Lesion ◽  
Lateral Wall ◽  
Inverted Papilloma ◽  
Intracranial Extension ◽  
Rare Presentation ◽  
Frontal Lobe Syndrome

Abstract Inverted papilloma is an uncommon tumor mostly arising from the lateral wall of the nasal cavity and displays a benign but locally aggressive behavior. Intracranial extension is an extremely rare presentation of inverted papilloma. Extension occurs either as a benign lesion or due to malignant transformation. We report a case of concurrent inverted papilloma and squamous cell carcinoma presenting with epistaxis and recent-onset altered behavior and memory impairment. After literature review of similar cases having inverted papilloma with intracranial extension, we could identify a total of 12 cases, most of which were recurrences of a primary inverted papilloma that were resected before extension into the cranial cavity. Most cases were of extradural extension, and intradural spread resulted in poor prognosis on follow-up. Concurrent inverted papilloma and squamous cell carcinoma extending into the anterior cranial fossa and frontal lobe is a very rare clinical entity and can present as frontal lobe syndrome.

Predicting progression in the late onset frontal lobe syndrome

2018 ◽  
Vol 31 (5) ◽  
pp. 743-748 ◽  
Author(s):  
Flora T. Gossink ◽  
Everard Vijverberg ◽  
Welmoed Krudop ◽  
Philip Scheltens ◽  
Max L. Stek ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Clinical Symptoms ◽  
Late Onset ◽  
Clinical Syndrome ◽  
Clinical Markers ◽  
Neuropsychological Profile ◽  
Stereotypical Behavior ◽  
Executive Deficits ◽  
Magnetic Resonance Imaging Mri ◽  
Frontal Lobe Syndrome

ABSTRACTA late onset frontal lobe syndrome (LOF) refers to a clinical syndrome with apathy, disinhibition, or stereotypical behavior arising in middle or late adulthood. Diagnostics are challenging, and both clinicians and patients need reliable predictors of progression to improve clinical guidance. In this longitudinal multicenter and genetically screened prospective study, 137 LOF patients with frontal behavior (FBI score≥11) and/or stereotypical behavior (SRI≥10) were included. Progression was defined as institutionalization, death, or progression of frontal or temporal atrophy at magnetic resonance imaging (MRI) after two years of follow up. Absence of progression at MRI in addition to stable or improved Mini Mental State Examination and Frontal Assessment Battery scores after two years was indicative for non-progression. The presence of stereotypy and a neuropsychological profile with executive deficits at baseline were found to be predictive for progression, while a history and family history with psychiatric disorders were predictors for non-progression. The combination of these clinical markers had a predictive value of 80.4% (p < 0.05). In patients presenting with late onset behavioral symptoms, an appraisal of the rate of deterioration can be made by detailed mapping of clinical symptoms. Distinction of progressive discourses from non-progressive or treatable conditions is to be gained.

scholarly journals Late adult-onset adrenomyeloneuropathy evolving with atypical severe frontal lobe syndrome: Importance of neuroimaging

2019 ◽  
Vol 14 (3) ◽  
pp. 309-314 ◽  
Author(s):  
Clemente Dato ◽  
Guglielmo Capaldo ◽  
Chiara Terracciano ◽  
Filomena Napolitano ◽  
Alessandra D'Amico ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Adult Onset ◽  
Frontal Lobe Syndrome

scholarly journals Criminal Responsibility of the Frontal Lobe Syndrome

2015 ◽  
Vol 47 (3) ◽  
pp. 218-222 ◽  
Author(s):  
Mustafa Talip Sener ◽  
Halil Ozcan ◽  
Sadik Sahingoz ◽  
Hayri Ogul
Keyword(s):  
Frontal Lobe ◽  
Criminal Responsibility ◽  
Frontal Lobe Syndrome

scholarly journals Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves

2021 ◽  
Author(s):  
Lea L. Backhausen ◽  
Juliane H. Froehner ◽  
Herve Lemaitre ◽  
Eric Artiges ◽  
Marie-Laure Paillere-Martinot ◽  
...  
Keyword(s):  
Sex Differences ◽  
Brain Development ◽  
Adolescent Psychopathology ◽  
Control Procedure ◽  
Structural Development ◽  
Age Related ◽  
Subcortical Regions ◽  
Relationship Of ◽  
First Time ◽  
The Relationship

Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in structural development. However, previous studies showed inconsistencies in subcortical trajectories and potential sex differences. Therefore, we aimed to investigate the subcortical structural trajectories and their sex differences across adolescence using for the first time a single cohort design, the same quality control procedure, software and a general additive mixed modeling approach. We investigated two large European sites from ages 14 to 24 with 503 participants and 1408 total scans from France and Germany as part of the IMAGEN project including four waves of data acquisition. We found significantly larger volumes in males versus females in both sites and across all seven subcortical regions. Sex differences in age-related trajectories were observed across all regions in both sites. Our findings provide further evidence of sex differences in longitudinal adolescent brain development of subcortical regions and thus might eventually support the relationship of underlying brain development and different adolescent psychopathology in boys and girls.

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