Association between Intermediate Uveitis and Multiple Sclerosis

2015 ◽  
pp. 99-105 ◽  
Author(s):  
M. A. J. Wagemans ◽  
A. C. Breebaart
Keyword(s):  
Multiple Sclerosis ◽  
Intermediate Uveitis

scholarly journals A case of multiple sclerosis with bilateral intermediate uveitis

2015 ◽  
Vol 55 (10) ◽  
pp. 716-721
Author(s):  
Hiroto Nakano ◽  
Kenichi Sakajiri ◽  
Eishun Nitta ◽  
Atsushi Nagata ◽  
Toshiyuki Takahashi
Keyword(s):  
Multiple Sclerosis ◽  
Intermediate Uveitis

Intermediate uveitis and multiple sclerosis: to scan or not to scan: Table 1

2015 ◽  
Vol 99 (12) ◽  
pp. 1591-1593 ◽  
Author(s):  
Harry Petrushkin ◽  
Desmond Kidd ◽  
Carlos Pavesio
Keyword(s):  
Multiple Sclerosis ◽  
Intermediate Uveitis

scholarly journals Gender and Uveitis in Patients with Multiple Sclerosis

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Lynn K. Gordon ◽  
Debra A. Goldstein
Keyword(s):  
Multiple Sclerosis ◽  
Central Nervous System ◽  
Nervous System ◽  
Demyelinating Disease ◽  
Retinal Vasculitis ◽  
Signs And Symptoms ◽  
Intraocular Inflammation ◽  
Tnf Inhibitor ◽  
Intermediate Uveitis ◽  
The Central Nervous System

Multiple sclerosis (MS), a demyelinating disease of the central nervous system, is more commonly seen in women. It has been associated with both anterior and intermediate uveitis as well as retinal vasculitis. Ocular inflammation may develop concurrent with, prior to, or after the development of neurologic signs and symptoms. Patients with MS have an approximately 1% chance of developing intraocular inflammation. Patients with intermediate uveitis have an 8–12% risk of being diagnosed with MS. This risk is higher in females and in those with bilateral disease. This should be kept in mind when evaluating patients with uveitis, particularly in those patients for whom TNF inhibitor therapy is being considered, as these agents may worsen demyelinating disease.

IL2RA Gene Polymorphism rs2104286 A>G Seen in Multiple Sclerosis Is Associated with Intermediate Uveitis: Possible Parallel Pathways?

2011 ◽  
Vol 52 (11) ◽  
pp. 8295 ◽  
Author(s):  
Ewald Lindner ◽  
Martin Weger ◽  
Gernot Steinwender ◽  
Antonia Griesbacher ◽  
Ursula Posch ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphism ◽  
Intermediate Uveitis ◽  
Parallel Pathways

scholarly journals Analysis of a Functional IL-6 Gene Polymorphism in HLAB27 Associated and Intermediate Uveitis Gives New Insight in Disease Pathogenesis and Commonality with Other Autoimmune Diseases

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Lindner Ewald ◽  
Langner-Wegscheider Beate ◽  
Sarny Stephanie ◽  
Renner Wilfried ◽  
El-Shabrawi Yosuf
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphism ◽  
Autoimmune Diseases ◽  
Case Control Study ◽  
Minor Allele ◽  
Genotype Distribution ◽  
Intermediate Uveitis ◽  
Polymerase Chain ◽  
Control Study ◽  
Positive Controls

Purpose. Interleukin 6 (IL-6) plays a crucial role in both adaptive and innate immunity. The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis.Methods. 134 patients with HLAB27 positive iridocyclitis, 84 patients with intermediate uveitis, 132 controls, and 65 HLAB27 positive controls were recruited for the present case-control study. Main outcome measures were genotype distribution and allelic frequencies determined by polymerase chain reaction.Results. The frequency of carriers of the minor allele for rs1800795 was significantly higher in patients with intermediate uveitis compared to controls (p=0.04; OR: 1.46; CI: 1.02–2.11). Frequencies of the minor allele for rs1800795 did not differ significantly in patients with HLAB27 associated uveitis when compared to controls (p>0.05).Conclusion. These findings further deepen our understanding of the commonality between multiple sclerosis and intermediate uveitis. Given the functionality of the investigated polymorphism, new pathophysiological insights are gained that help to evaluate possible therapeutic targets.

Intermediate uveitis in childhood preceding the diagnosis of multiple sclerosis: a 13-year follow-up

2003 ◽  
Vol 135 (6) ◽  
pp. 885-886 ◽  
Author(s):  
Jens F. Jordan ◽  
Peter Walter ◽  
Helen D. Ayertey ◽  
Richard Brunner
Keyword(s):  
Multiple Sclerosis ◽  
Intermediate Uveitis

Efficacy of Natalizumab in Intermediate Uveitis Related to Multiple Sclerosis: A Case Report

2018 ◽  
Vol 235 (04) ◽  
pp. 476-477 ◽  
Author(s):  
Ségolène Roemer ◽  
Alexandre Bissig ◽  
Alda Rocca ◽  
Renaud Du Pasquier ◽  
Yan Guex-Crosier
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
Intermediate Uveitis
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