scholarly journals Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Single Dose ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Low Risk ◽  
Intraoperative Radiation Therapy ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Risk Breast Cancer

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.

scholarly journals Intraoperative Radiation Therapy Combined with Hyperthermia against Pancreatic Carcinoma.

1992 ◽  
Vol 166 (3) ◽  
pp. 395-401 ◽  
Author(s):  
SHOGO YAMADA ◽  
YOSHIHIRO TAKAI ◽  
KENJI NEMOTO ◽  
YOSHIHIRO OGAWA ◽  
YOSHIHISA KAKUTO ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pancreatic Carcinoma ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation

Intraoperative radiation therapy in the management of gynecologic and genitourinary malignancies

2003 ◽  
Vol 12 (4) ◽  
pp. 1031-1042 ◽  
Author(s):  
Marcela G del Carmen ◽  
Brian Eisner ◽  
Christopher G Willet ◽  
Arlan F Fuller
Keyword(s):  
Radiation Therapy ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation

scholarly journals PD-0479: Intraoperative radiation therapy for breast cancer with INTRABEAMÆ: minimizing cost analysis

2015 ◽  
Vol 115 ◽  
pp. S236-S237
Author(s):  
B. Pinar ◽  
N. Rodriguez-Ibarria ◽  
M.A. Cabezon-Pons ◽  
D. Rey-Baltar ◽  
J.M. Blanco-Suarez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cost Analysis ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation
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