120-h Continuous Infusion of Ifosfamide Alone and in Combination with Cis-Platinurc in Children and Adolescents with Recurrent Ewing’s Sarcoma1

1987 ◽  
pp. 131-138 ◽  
Author(s):  
V. Bier ◽  
H. Jürgens ◽  
G. Etspüler ◽  
U. Exner ◽  
J Kühl ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Continuous Infusion

scholarly journals Relapsed or Refractory Burkitt Lymphoma in Children and Adolescents after BFM-Type First-Line Therapy - a BFM Group Report

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 1738-1738 ◽  
Author(s):  
Wilhelm Woessmann ◽  
Martin Zimmermann ◽  
Birgit Burkhardt ◽  
Andrea Meinhardt ◽  
Christine Rosenbusch ◽  
...  
Keyword(s):  
Risk Factor ◽  
Children And Adolescents ◽  
Continuous Infusion ◽  
Burkitt Lymphoma ◽  
Significant Risk ◽  
Front Line ◽  
First Line ◽  
Hematopoietic Stem ◽  
First Line Therapy ◽  
Line Therapy

Abstract Introduction: Current effective front-line therapies for Burkitt lymphoma leave few patients with relapsed or refractory disease. The objective of this analysis was to evaluate outcome, re-induction and SCT -approaches as well as risk factors in children and adolescents with progression or relapse of a Burkitt lymphoma/leukemia after current BFM-type first-line therapy. Patients and Methods: We analyzed a population-based cohort of 145 children with relapsed Burkitt lymphoma/leukemia after BFM-type first-line therapy between 1986 and 2013. Recommended salvage until 2000 was BFM-type re-induction chemotherapy followed by autologous hematopoietic stem cell transplantation (SCT). From 2001 on different re-inductions were used, Rituximab was applied in relapse and both autologous and allogeneic SCT were performed. Results:With a median follow-up of 8.2 (2.7-9.6) years, the 4-year survival after first relapse was 15±3%. Survival significantly improved for patients with relapse/progression after 2000 (until 2000, n=82: 11±3%, 2001 and later, n=63: 21±5%, p=.004) so that further risk factor analyses were performed on these 63 patients: Almost all patients with progression during front-line therapy (21/22), progression during re-induction (26/27), those not reaching CR before SCT (14/15) or not receiving rituximab during re-induction (9/9) died. Survival of 12 patients relapsing after initial therapy for low risk disease (R1/R2) was 42±14% compared to 16±5% for 51 patients relapsing after R3/R4-therapy (p=.02). CNS involvement could not be confirmed as statistically significant risk factor. Re-induction by CC (25 patients), ICE (8 patients), ICI (6 patients) or other regimen (11 patients) was followed by SCT in 31 patients (autologous, 18 patients; allogeneic, 13 patients). These approaches were associated with comparable survival of 16±5%. Two centers used a strategy of two to three courses of intensive continuous-infusion re-induction based on Vincristin (or Paclitaxel), Ifosfamide, Carboplatin, Idarubicine, Rituximab and intrathecal triple therapy without complete hematological regeneration between courses followed by allogeneic SCT. Survival of 8 patients treated this way was 63±17% (p=.034 as compared to the survival with other regimen). A center-effect may confound. Conclusion: Patients with relapsed Burkitt lymphoma/leukemia still have a poor chance to survive after current effective front-line therapy. Time-condensed continuous-infusion re-induction with CD20-antibodies followed by SCT might form the basis for trials testing new drugs. Disclosures Off Label Use: Most chemotherapy drugs used for relapsed Burkitt lymphoma as well as Rituximab are not licenced for children and adolescents..

Analyzing the Potential Benefit of Microcomputer Use for Teaching Figurative Language

1992 ◽  
Vol 1 (2) ◽  
pp. 36-43 ◽  
Author(s):  
Marilyn A. Nippold ◽  
Ilsa E. Schwarz ◽  
Molly Lewis
Keyword(s):  
Language Learning ◽  
Children And Adolescents ◽  
Standardized Tests ◽  
Figurative Language ◽  
Language Intervention ◽  
School Age Children ◽  
Educational Materials ◽  
Language Learning Disabilities ◽  
Promising Application ◽  
Experience Difficulty

Microcomputers offer the potential for increasing the effectiveness of language intervention for school-age children and adolescents who have language-learning disabilities. One promising application is in the treatment of students who experience difficulty comprehending figurative expressions, an aspect of language that occurs frequently in both spoken and written contexts. Although software is available to teach figurative language to children and adolescents, it is our feeling that improvements are needed in the existing programs. Software should be reviewed carefully before it is used with students, just as standardized tests and other clinical and educational materials are routinely scrutinized before use. In this article, four microcomputer programs are described and evaluated. Suggestions are then offered for the development of new types of software to teach figurative language.

Re-examination of incisal tooth wear in children and adolescents

1997 ◽  
Vol 24 (6) ◽  
pp. 405-409 ◽  
Author(s):  
J. SILNESS ◽  
M. BERGE ◽  
G JOHANNESSEN
Keyword(s):  
Children And Adolescents ◽  
Tooth Wear
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