Production of Human Gamma Interferon for Clinical Trials1

1982 ◽  
pp. 135-143
Author(s):  
Peter von Wussow ◽  
Michelle Chen ◽  
Chris D. Platsoucas ◽  
Marzenna Wiranowska-Stewart ◽  
William E. Stewart
Keyword(s):  
Gamma Interferon

Paradoxical antidiabetogenic effect of gamma-interferon in DP-BB rats

Diabetes ◽  
1998 ◽  
Vol 47 (1) ◽  
pp. 32-38 ◽  
Author(s):  
F. Nicoletti ◽  
P. Zaccone ◽  
R. Di Marco ◽  
G. Magro ◽  
S. Grasso ◽  
...  
Keyword(s):  
Gamma Interferon ◽  
Bb Rats

Human gamma interferon production by cytotoxic T lymphocytes sensitized during hepatitis A virus infection.

1988 ◽  
Vol 62 (10) ◽  
pp. 3756-3763 ◽  
Author(s):  
K Maier ◽  
P Gabriel ◽  
E Koscielniak ◽  
Y D Stierhof ◽  
K H Wiedmann ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Virus Infection ◽  
Cytotoxic T Lymphocytes ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Gamma Interferon ◽  
Interferon Production

Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis.

1995 ◽  
Vol 69 (9) ◽  
pp. 5469-5474 ◽  
Author(s):  
D Finke ◽  
U G Brinckmann ◽  
V ter Meulen ◽  
U G Liebert
Keyword(s):  
Measles Virus ◽  
Gamma Interferon ◽  
Antiviral Defense ◽  
Major Mediator

scholarly journals Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency

2006 ◽  
Vol 80 (1) ◽  
pp. 192-200 ◽  
Author(s):  
Ashley L. Steed ◽  
Erik S. Barton ◽  
Scott A. Tibbetts ◽  
Daniel L. Popkin ◽  
Mary L. Lutzke ◽  
...  
Keyword(s):  
Immune Surveillance ◽  
Viral Gene Expression ◽  
Gamma Interferon ◽  
Viral Gene ◽  
Herpesvirus Infection ◽  
Murine Gammaherpesvirus ◽  
Ifn Γ ◽  
Gammaherpesvirus 68 ◽  
Novel Strategy

ABSTRACT Establishment of latent infection and reactivation from latency are critical aspects of herpesvirus infection and pathogenesis. Interfering with either of these steps in the herpesvirus life cycle may offer a novel strategy for controlling herpesvirus infection and associated disease pathogenesis. Prior studies show that mice deficient in gamma interferon (IFN-γ) or the IFN-γ receptor have elevated numbers of cells reactivating from murine gammaherpesvirus 68 (γHV68) latency, produce infectious virus after the establishment of latency, and develop large-vessel vasculitis. Here, we demonstrate that IFN-γ is a powerful inhibitor of reactivation of γHV68 from latency in tissue culture. In vivo, IFN-γ controls viral gene expression during latency. Importantly, depletion of IFN-γ in latently infected mice results in an increased frequency of cells reactivating virus. This demonstrates that IFN-γ is important for immune surveillance that limits reactivation of γHV68 from latency.

scholarly journals Differential effects of gamma-interferon on collagen and fibronectin gene expression.

1987 ◽  
Vol 262 (27) ◽  
pp. 13348-13351
Author(s):  
M J Czaja ◽  
F R Weiner ◽  
M Eghbali ◽  
M A Giambrone ◽  
M Eghbali ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gamma Interferon ◽  
Differential Effects
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