The Results of Chemotherapy in Inoperable Non-Small Cell Bronchogenic Cancer

1981 ◽  
pp. 368-370
Author(s):  
W. Wellens ◽  
M. Westerhausen ◽  
R. M. Konrad ◽  
V. Rausch
Keyword(s):  
Small Cell ◽  
Bronchogenic Cancer

Bronchogenic Cancer and Bullous Lung Disease

2010 ◽  
pp. 162-165
Author(s):  
Edward C. Rosenow
Keyword(s):  
Lung Disease ◽  
Cell Cancer ◽  
Small Cell ◽  
Small Cell Cancer ◽  
Bullous Disease ◽  
Increased Risk ◽  
Bronchogenic Cancer

• Bullous lung disease occurs in 4% of patients with bronchogenic cancer • 30-fold increased risk of bronchogenic cancer in bullous lung disease versus no bullous disease • All are smokers • Non-small-cell cancer; may be a scar carcinoma • Average age: 42 years •...

Adrenocorticotropin Production by a Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 462-463
Author(s):  
K.S. McCarty ◽  
N.R. Wallace ◽  
W. Litaker ◽  
S. Wells ◽  
G. Eisenbarth
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Small Cell ◽  
Hormone Production ◽  
Carcinoma Of The Breast ◽  
Ectopic Acth ◽  
Ultrastructural Studies ◽  
Subcutaneous Metastases ◽  
Ectopic Acth Production ◽  
The Right ◽  
Pituitary Carcinomas

The production of adrenocorticotropic hormone by non-pituitary carcinomas has been documented in several tumors, most frequently small cell carcinoma of the lung, islet cell carcinomas of the pancreas, thymomas and carcinoids. Electron microscopy of these tumors reveals typical membrane-limited "neurosecretory" granules. Confirmation of the granules as adrenocorticotropin (ACTH) requires the use of OsO4 as a primary fixative to give the characteristic cored granule appearance in conjunction with immunohistochemical demonstration of the hormone peptide. Because of the rarity of ectopic ACTH production by mammary carcinomas and the absence of appropriate ultrastructural studies in the two examples of such ectopic hormone production in the literature of which we are aware (1,2), we present biochemical and ultrastructural data from a carcinoma of the breast with apparent ACTH production.The patient had her primary tumor in the right breast in 1969. The tumor recurred as visceral and subcutaneous metastases in 1976 and again in 1977.

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