REM Sleep and Memory Consolidation in Humans

2015 ◽  
pp. 453-457
Author(s):  
M. Bertini ◽  
A. Torre
Keyword(s):  
Rem Sleep ◽  
Memory Consolidation

scholarly journals Sounding It Out: Auditory Stimulation and Overnight Memory Processing

2021 ◽  
Author(s):  
Marcus O. Harrington ◽  
Scott A. Cairney
Keyword(s):  
Rem Sleep ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Auditory Stimulation ◽  
Theta Oscillations ◽  
Neural Oscillations ◽  
Healthy Children ◽  
Factors Affecting ◽  
Memory Processing ◽  
Eeg Recordings

Abstract Purpose of Review Auditory stimulation is a technique that can enhance neural oscillations linked to overnight memory consolidation. In this review, we evaluate the impacts of auditory stimulation on the neural oscillations of sleep and associated memory processes in a variety of populations. Recent Findings Cortical EEG recordings of slow-wave sleep (SWS) are characterised by two cardinal oscillations: slow oscillations (SOs) and sleep spindles. Auditory stimulation delivered in SWS enhances SOs and phase-coupled spindle activity in healthy children and adults, children with ADHD, adults with mild cognitive impairment and patients with major depression. Under certain conditions, auditory stimulation bolsters the benefits of SWS for memory consolidation, although further work is required to fully understand the factors affecting stimulation-related memory gains. Recent work has turned to rapid eye movement (REM) sleep, demonstrating that auditory stimulation can be used to manipulate REM sleep theta oscillations. Summary Auditory stimulation enhances oscillations linked to overnight memory processing and shows promise as a technique for enhancing the memory benefits of sleep.

scholarly journals Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniel Gomes de Almeida-Filho ◽  
Bruna Del Vechio Koike ◽  
Francesca Billwiller ◽  
Kelly Soares Farias ◽  
Igor Rafael Praxedes de Sales ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Memory Consolidation ◽  
Retrosplenial Cortex ◽  
Contextual Fear Conditioning ◽  
Oscillatory Activity ◽  
Theta Oscillation ◽  
Contextual Fear ◽  
Before And After ◽  
Freely Behaving ◽  
Phasic Rem Sleep

AbstractHippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenon.

scholarly journals Shining a Light on the Mechanisms of Sleep for Memory Consolidation

2021 ◽  
Author(s):  
Michelle A. Frazer ◽  
Yesenia Cabrera ◽  
Rockelle S. Guthrie ◽  
Gina R. Poe
Keyword(s):  
Rem Sleep ◽  
Neural Activity ◽  
Memory Consolidation ◽  
Strong Support ◽  
Nrem Sleep ◽  
Future Research ◽  
Sleep Spindles ◽  
Slow Oscillations ◽  
Theta Waves ◽  
Learning Tasks

Abstract Purpose of review This paper reviews all optogenetic studies that directly test various sleep states, traits, and circuit-level activity profiles for the consolidation of different learning tasks. Recent findings Inhibiting or exciting neurons involved either in the production of sleep states or in the encoding and consolidation of memories reveals sleep states and traits that are essential for memory. REM sleep, NREM sleep, and the N2 transition to REM (characterized by sleep spindles) are integral to memory consolidation. Neural activity during sharp-wave ripples, slow oscillations, theta waves, and spindles are the mediators of this process. Summary These studies lend strong support to the hypothesis that sleep is essential to the consolidation of memories from the hippocampus and the consolidation of motor learning which does not necessarily involve the hippocampus. Future research can further probe the types of memory dependent on sleep-related traits and on the neurotransmitters and neuromodulators required.

Pharmacologically Increasing Sleep Spindles Enhances Recognition for Negative and High-arousal Memories

2013 ◽  
Vol 25 (10) ◽  
pp. 1597-1610 ◽  
Author(s):  
Erik J. Kaestner ◽  
John T. Wixted ◽  
Sara C. Mednick
Keyword(s):  
Rem Sleep ◽  
Memory Consolidation ◽  
Declarative Memory ◽  
Memory Performance ◽  
Emotional Memory ◽  
Limited Range ◽  
Sleep Spindles ◽  
Sleep Spindle ◽  
Emotional Stimuli ◽  
Valence And Arousal

Sleep affects declarative memory for emotional stimuli differently than it affects declarative memory for nonemotional stimuli. However, the interaction between specific sleep characteristics and emotional memory is not well understood. Recent studies on how sleep affects emotional memory have focused on rapid eye movement sleep (REM) but have not addressed non-REM sleep, particularly sleep spindles. This is despite the fact that sleep spindles are implicated in declarative memory as well as neural models of memory consolidation (e.g., hippocampal neural replay). Additionally, many studies examine a limited range of emotional stimuli and fail to disentangle differences in memory performance because of variance in valence and arousal. Here, we experimentally increase non-REM sleep features, sleep spindle density, and SWS, with pharmacological interventions using zolpidem (Ambien) and sodium oxybate (Xyrem) during daytime naps. We use a full spread of emotional stimuli to test all levels of valence and arousal. We find that increasing sleep spindle density increases memory discrimination (da) for highly arousing and negative stimuli without altering measures of bias (ca). These results indicate a broader role for sleep in the processing of emotional stimuli with differing effects based on arousal and valence, and they raise the possibility that sleep spindles causally facilitate emotional memory consolidation. These findings are discussed in terms of the known use of hypnotics in individuals with emotional mood disorders.

Contribution of the Premotor Cortex to Consolidation of Motor Sequence Learning in Humans During Sleep

2010 ◽  
Vol 104 (5) ◽  
pp. 2603-2614 ◽  
Author(s):  
Michael A. Nitsche ◽  
Michaela Jakoubkova ◽  
Nivethida Thirugnanasambandam ◽  
Leonie Schmalfuss ◽  
Sandra Hullemann ◽  
...  
Keyword(s):  
Reaction Time ◽  
Task Performance ◽  
Rem Sleep ◽  
Sequence Learning ◽  
Memory Consolidation ◽  
Primary Motor Cortex ◽  
Premotor Cortex ◽  
Reaction Time Task ◽  
Motor Memory ◽  
Motor Sequence

Motor learning and memory consolidation require the contribution of different cortices. For motor sequence learning, the primary motor cortex is involved primarily in its acquisition. Premotor areas might be important for consolidation. In accordance, modulation of cortical excitability via transcranial DC stimulation (tDCS) during learning affects performance when applied to the primary motor cortex, but not premotor cortex. We aimed to explore whether premotor tDCS influences task performance during motor memory consolidation. The impact of excitability-enhancing, -diminishing, or placebo premotor tDCS during rapid eye movement (REM) sleep on recall in the serial reaction time task (SRTT) was explored in healthy humans. The motor task was learned in the evening. Recall was performed immediately after tDCS or the following morning. In two separate control experiments, excitability-enhancing premotor tDCS was performed 4 h after task learning during daytime or immediately before conduction of a simple reaction time task. Excitability-enhancing tDCS performed during REM sleep increased recall of the learned movement sequences, when tested immediately after stimulation. REM density was enhanced by excitability-increasing tDCS and reduced by inhibitory tDCS, but did not correlate with task performance. In the control experiments, tDCS did not improve performance. We conclude that the premotor cortex is involved in motor memory consolidation during REM sleep.

scholarly journals Slow Wave Sleep and REM Sleep Awakenings Do Not Affect Sleep Dependent Memory Consolidation

SLEEP ◽  
2009 ◽  
Vol 32 (3) ◽  
pp. 302-310 ◽  
Author(s):  
Lisa Genzel ◽  
Martin Dresler ◽  
Renate Wehrle ◽  
Michael Grözinger ◽  
Axel Steiger
Keyword(s):  
Slow Wave ◽  
Rem Sleep ◽  
Memory Consolidation ◽  
Slow Wave Sleep

scholarly journals Mechanisms Underlying Memory Consolidation by Adult-Born Neurons During Sleep

2020 ◽  
Vol 14 ◽  
Author(s):  
Pablo Vergara ◽  
Masanori Sakaguchi
Keyword(s):  
Eye Movement ◽  
Rem Sleep ◽  
Memory Consolidation ◽  
Memory System ◽  
Rapid Eye Movement ◽  
Unique Form ◽  
Synaptic Remodeling ◽  
Adult Born Neurons ◽  
Underlying Mechanisms ◽  
Definition Of

The mammalian hippocampus generates new neurons that incorporate into existing neuronal networks throughout the lifespan, which bestows a unique form of cellular plasticity to the memory system. Recently, we found that hippocampal adult-born neurons (ABNs) that were active during learning reactivate during subsequent rapid eye movement (REM) sleep and provided causal evidence that ABN activity during REM sleep is necessary for memory consolidation. Here, we describe the potential underlying mechanisms by highlighting distinct characteristics of ABNs including decoupled firing from local oscillations and ability to undergo profound synaptic remodeling in response to experience. We further discuss whether ABNs constitute the conventional definition of engram cells by focusing on their active and passive roles in the memory system. This synthesis of evidence helps advance our thinking on the unique mechanisms by which ABNs contribute to memory consolidation.

scholarly journals The influence of REM sleep and SWS on emotional memory consolidation in participants reporting depressive symptoms

Cortex ◽  
2018 ◽  
Vol 99 ◽  
pp. 281-295 ◽  
Author(s):  
Marcus O. Harrington ◽  
Jennifer M. Johnson ◽  
Harriet E. Croom ◽  
Kyla Pennington ◽  
Simon J. Durrant
Keyword(s):  
Depressive Symptoms ◽  
Rem Sleep ◽  
Memory Consolidation ◽  
Emotional Memory
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