Rationale and Results of Combination Chemotherapy and Central Nervous System Irradiation in Acute Lymphocytic Leukemia

2015 ◽  
pp. 1068-1073 ◽  
Author(s):  
J. Simone ◽  
D. Pinkel
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Combination Chemotherapy ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia

scholarly journals Central Nervous System Therapy and Combination Chemotherapy of Childhood Lymphocytic Leukemia

Blood ◽  
1971 ◽  
Vol 37 (3) ◽  
pp. 272-281 ◽  
Author(s):  
RHOMES J. A. AUR ◽  
JOSEPH SIMONE ◽  
H. OMAR HUSTU ◽  
THOMAS WALTERS ◽  
LUIS BORELLA ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Complete Remission ◽  
Combination Chemotherapy ◽  
Acute Lymphocytic Leukemia ◽  
Viral Infections ◽  
Combined Therapy ◽  
Lymphocytic Leukemia ◽  
Intrathecal Methotrexate ◽  
Central Nervous System Relapse

Abstract In earlier combination chemotherapy regimens for childhood acute lymphocytic leukemia, nervous system leukemia terminated complete remission in over half the patients in a median time of 11 months. In the present study, cranial radiation (2400 R, 60Co) and intrathecal methotrexate given early in remission were added to combination chemotherapy in an attempt to prevent or delay central nervous system relapse and termination of complete remission. Of 35 consecutive children with previously untreated acute lymphocytic leukemia, 20 of 30 who attained remission and received all initial phases of therapy have been in continuous complete remission for 23 to 30 months. Complete remission was terminated by nervous system relapse in three patients and by hematological relapse in five. Two patients died in complete remission of viral infections and others experienced reversible drug toxicity. We conclude that this combined therapy reduces the incidence of nervous system relapse in the first 2 years and prolongs complete remission.

Methotrexate Infusions as Central Nervous System Prophylaxis in Children with Acute Lymphocytic Leukemia: The Norwegian Experience

2003 ◽  
Vol 20 (3) ◽  
pp. 187-200
Author(s):  
Peter Johan Moe ◽  
Are Holen ◽  
Randi Nygaard ◽  
Anders Glomstein ◽  
Birgit Madsen ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Central Nervous System Prophylaxis

Effects of Central-Nervous-System Irradiation on Neuropsychologic Functioning of Children with Acute Lymphocytic Leukemia

1975 ◽  
Vol 293 (3) ◽  
pp. 113-118 ◽  
Author(s):  
Sileen S. Soni ◽  
George W. Marten ◽  
Samuel E. Pitner ◽  
Danilo A. Duenas ◽  
Morris Powazek
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia
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