Current Status of Plasma Fraction Therapy in Hemophilia A

2015 ◽  
pp. 784-788
Author(s):  
K. M. Brinkhous
Keyword(s):  
Hemophilia A ◽  
Current Status ◽  
Plasma Fraction

scholarly journals Point-of-care ultrasonography (POCUS) in hemophilia A: a commentary on current status and its potential role for improving prophylaxis management in severe hemophilia A

2017 ◽  
Vol 8 (4) ◽  
pp. 153-156 ◽  
Author(s):  
Suchitra S. Acharya ◽  
Brittny Rule ◽  
Omar McMillan ◽  
Thomas J. Humphries
Keyword(s):  
Hemophilia A ◽  
Point Of Care ◽  
Scoring Systems ◽  
Current Status ◽  
Recurrent Bleeding ◽  
Severe Hemophilia ◽  
Transitional Age ◽  
Point Of Care Ultrasonography ◽  
User Friendly

In patients with severe hemophilia A, recurrent bleeding into joints results in increased morbidity and reduced quality of life. Prophylaxis using replacement factor products, especially when initiated early, has established benefits in terms of reducing joint bleeds and preserving joint function. Poor adherence to prophylactic regimens is a common cause for breakthrough bleeds and resultant arthropathy. Improving prophylaxis management, especially in the transitional age group, is a challenge. Here, we discuss the current status of ultrasonography (US) in hemophilia A, challenges in its wider implementation, and the potential for use of point-of-care US (POCUS) as an adjunct in the routine management of patients with hemophilia following prophylaxis regimens. Using POCUS, in which US is performed by trained hematologists and nonphysician operators (rather than comprehensive US performed by imaging specialists), specific clinical questions can be addressed in a time-efficient, user-friendly manner to promote adherence to prophylaxis and guide or modify treatment approaches. This review also discusses barriers to acceptance of POCUS as a part of routine management of patients with hemophilia, including questions related to its diagnostic accuracy, dependence on trained operators, agreement on appropriate scoring systems, and potential usefulness in patient management.

scholarly journals Oral Prophylactic Therapy in Hemophilia A and B (Factor VIII and IX Deficiencies)

1977 ◽  
Author(s):  
W.F. Stapp ◽  
H.B. Boudreaux
Keyword(s):  
Factor Viii ◽  
Hemophilia A ◽  
Case Reports ◽  
Factor Ix ◽  
Term Therapy ◽  
Prophylactic Therapy ◽  
Plasma Fraction ◽  
Plasma Factor ◽  
Alternative Means

The purpose of this ongoing nutritional study with massive doses of choline ultimately is to try and establish an alternative means of prophylactic therapy to recently proposed use of plasma fractions, plasma factor concentrates and earlier so-called “bleeding and clotting diets”. Contrary to other prophylactic therapy studies, our premise is that if all other hemostatic and homeostatic factors are near normal through optimum nutrition, the over-all importance of Factor VIII and Factor IX deficiencies are less significant.Case reports of patients with Hemophilia A and B are presented, which indicate a comparative decrease in the plasma fraction requirements for the treatment of the bleeding episodes in these patients during long term therapy with megavitamin doses of choline (a refinement of Boudreaux’s “peanut factor”). One case (WFS) of severe Hemophilia A with less than 1% Factor VIII, under therapy for over 10 yeara has had periods of remission not requiring plasma factor infusions for almost 2 years.From our combined studies, we conclude that a long term nutritional prophylactic therapy program with emphasis on choline in Hemophilia A and B can result in a decrease in plasma needs. antibody formation and the occurrence of hepatitis.

Current status of special planetary and lunar theories and ephemerides

1966 ◽  
Vol 25 ◽  
pp. 266-267
Author(s):  
R. L. Duncombe
Keyword(s):  
Observational Data ◽  
Current Status ◽  
Numerical Errors

An examination of some specialized lunar and planetary ephemerides has revealed inconsistencies in the adopted planetary masses, the presence of non-gravitational terms, and some outright numerical errors. They should be considered of temporary usefulness only, subject to subsequent amendment as required for the interpretation of observational data.

Current Status of Solid-State X-Ray Systems

1985 ◽  
Vol 43 ◽  
pp. 158-161
Author(s):  
Martin Peckerar ◽  
Anastasios Tousimis
Keyword(s):  
Solid State ◽  
Electric Fields ◽  
Spectral Lines ◽  
Current Status ◽  
Mobile Charge ◽  
Electron Hole ◽  
X Ray ◽  
Sensing Systems ◽  
Transmission Electron ◽  
Electron Microscopes

Solid state x-ray sensing systems have been used for many years in conjunction with scanning and transmission electron microscopes. Such systems conveniently provide users with elemental area maps and quantitative chemical analyses of samples. Improvements on these tools are currently sought in the following areas: sensitivity at longer and shorter x-ray wavelengths and minimization of noise-broadening of spectral lines. In this paper, we review basic limitations and recent advances in each of these areas. Throughout the review, we emphasize the systems nature of the problem. That is. limitations exist not only in the sensor elements but also in the preamplifier/amplifier chain and in the interfaces between these components.Solid state x-ray sensors usually function by way of incident photons creating electron-hole pairs in semiconductor material. This radiation-produced mobile charge is swept into external circuitry by electric fields in the semiconductor bulk.

Electron-deficient boron-based catalysts for C–H bond functionalisation

2021 ◽  
Author(s):  
Yuanhong Ma ◽  
Shao-Jie Lou ◽  
Zhaomin Hou
Keyword(s):  
Review Article ◽  
Current Status ◽  
Comprehensive Overview

This review article provides a comprehensive overview to recognise the current status of electron-deficient boron-based catalysis in C–H functionalisations.

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