The Relationship of Changes in the Serum Protein Fractions to the Cellular Reactions of the Bone Marrow in Malignant Lymphoma

2015 ◽  
pp. 182-184
Author(s):  
A. J. Awny
Keyword(s):  
Bone Marrow ◽  
Malignant Lymphoma ◽  
Serum Protein ◽  
Protein Fractions ◽  
Relationship Of ◽  
The Relationship

The Relationship of Serum Protein Bound Iodine Levels to Rates of Gain in Beef Cattle

1953 ◽  
Vol 12 (1) ◽  
pp. 3-9 ◽  
Author(s):  
H. O. Kunkel ◽  
R. W. Colby ◽  
Carl M. Lyman
Keyword(s):  
Beef Cattle ◽  
Serum Protein ◽  
Relationship Of ◽  
The Relationship

scholarly journals Proplatelets and stress platelets

Blood ◽  
1987 ◽  
Vol 69 (2) ◽  
pp. 522-528 ◽  
Author(s):  
M Tong ◽  
P Seth ◽  
DG Penington
Keyword(s):  
Bone Marrow ◽  
Platelet Rich Plasma ◽  
Early Period ◽  
Platelet Volume ◽  
Plasma Exposure ◽  
Functional Characteristics ◽  
Platelet Production ◽  
Relationship Of ◽  
The Relationship ◽  
Platelet Formation

Abstract The process of platelet formation by the fragmentation of megakaryocyte pseudopodia, termed proplatelets, demonstrable in the marrow sinusoids is poorly understood. “Stress” platelets produced under conditions of stimulated platelet production differ from normal circulating platelets with respect to volume and a number of functional characteristics. To clarify the relationship of stress platelets to proplatelets, rats were injected with heterologous platelet antiserum. Nondiscoid platelet forms, some characteristically beaded in appearance, strongly resembling bone marrow proplatelets, can be recovered in the circulation of normal rats. During the early period of recovery from acute thrombocytopenia, there was a substantial increase in the proportion of these elongated platelets in the citrated platelet rich plasma. Exposure to EDTA rendered them spherical. Circulating proplatelets may contribute significantly to the prompt increase in platelet volume during recovery from acute thrombocytopenia at a time prior to significant increase in megakaryocyte size and ploidy.

scholarly journals Expression of Shelterin ComponentPOT1Is Associated with Decreased Telomere Length and Immunity Condition in Humans with Severe Aplastic Anemia

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Ting Wang ◽  
Shu-chong Mei ◽  
Rong Fu ◽  
Hua-quan Wang ◽  
Zong-hong Shao
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Telomere Length ◽  
Bone Marrow Cells ◽  
Culture Media ◽  
Telomere Attrition ◽  
High Concentrations ◽  
Relationship Of ◽  
The Relationship ◽  
Marrow Cells

Abnormal telomere attrition has been found to be closely related to patients with SAA in recent years. To identify the incidence of telomere attrition in SAA patients and investigate the relationship of telomere length with clinical parameters, SAA patients(n=27)and healthy controls(n=15)were enrolled in this study. Telomere length of PWBCs was significantly shorter in SAA patients than in controls. Analysis of gene expression of Shelterin complex revealed markedly low levels ofPOT1expression in SAA groups relative to controls. No differences in the gene expression of the other Shelterin components—TRF1,TRF2,TIN2,TPP1, andRAP1—were identified. Addition of IFN-γto culture media induced a similar fall in POT1 expression in bone marrow cells to that observed in cells cultured in the presence of SAA serum, suggesting IFN-γis the agent responsible for this effect of SAA serum. Furthermore, ATR, phosphorylated ATR, and phosphorylated ATM/ATR substrate were all found similarly increased in bone marrow cells exposed to SAA serum, TNF-α, or IFN-γ. In summary, SAA patients have short telomeres and decreased POT1 expression. TNF-αand IFN-γare found at high concentrations in SAA patients and may be the effectors that trigger apoptosis through POT1 and ATR.

Steatorrhea and malignant lymphoma the relationship of malignant tumors of lymphoid tissue and celiac disease

1967 ◽  
Vol 12 (5) ◽  
pp. 475-490 ◽  
Author(s):  
W. I. Austad ◽  
J. S. Cornes ◽  
K. R. Gough ◽  
C. F. McCarthy ◽  
A. E. Read
Keyword(s):  
Celiac Disease ◽  
Malignant Lymphoma ◽  
Lymphoid Tissue ◽  
Malignant Tumors ◽  
Relationship Of ◽  
The Relationship

Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness

Blood ◽  
2004 ◽  
Vol 103 (8) ◽  
pp. 2965-2972 ◽  
Author(s):  
Heath L. Bradley ◽  
Christine Couldrey ◽  
Kevin D. Bunting
Keyword(s):  
Bone Marrow ◽  
Hematopoietic Stem ◽  
Fold Reduction ◽  
Thrombopoietin Receptor ◽  
Direct Head ◽  
Relationship Of ◽  
The Relationship

Abstract Signal transducer and activator of transcription-5 (STAT5) plays an important role in repopulating activity of hematopoietic stem cells (HSCs). However, the relationship of STAT5 activation with early acting cytokine receptors is not well established. We have directly compared bone marrow (BM) from mice mutant for STAT5a and STAT5b (STAT5ab-/-) with that from mice lacking c-Mpl (c-Mpl-/-), the thrombopoietin receptor. Both STAT5 and c-Mpl deficiency only mildly affected committed myeloid progenitors assayed in vitro, but STAT5ab-/- BM showed lower Gr-1+ (4.4-fold), B220+ (23-fold), CD4+ (20-fold), and Ter119+ (17-fold) peripheral blood repopulating activity than c-Mpl-/- BM against wild-type competitor in long-term repopulating assays in vivo. Direct head-to-head competitions of STAT5ab-/- BM and c-Mpl-/- BM showed up to a 25-fold reduction in STAT5ab-/- contribution. Differences affecting reconstitution of primitive c-Kit+Lin-Sca-1+ multipotent progenitor (MPP)/HSC (1.8-fold) and c-Kit+Lin-Sca-1- oligopotent progenitor BM fractions (3.3-fold) were more modest. In serial transplantation experiments, STAT5ab-/- and c-Mpl-/- BM both failed to provide consistent engraftment in tertiary hosts and could not radioprotect lethally irradiated quaternary recipients. These results indicate substantial overlap in c-Mpl-STAT5 signaling defects at the MPP/HSC level but indicate that STAT5 is activated independent of c-Mpl to promote multilineage hematopoietic differentiation. (Blood. 2004;103:2965-2972)

scholarly journals Cytochemical and Radioautographic Identification of Cells Induced to Synthesize Hemoglobin

Blood ◽  
1974 ◽  
Vol 43 (6) ◽  
pp. 885-898 ◽  
Author(s):  
Cornelius Rosse ◽  
John A. Trotter
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Monochromatic Light ◽  
Transitional Cell ◽  
Reticular Cell ◽  
Base Line ◽  
Hemoglobin Synthesis ◽  
Transitional Cells ◽  
Relationship Of ◽  
The Relationship

Abstract In order to facilitate the identification of bone marrow cells in which hemoglobin synthesis is initiated, erythropoiesis was first suppressed in guinea pigs through the induction of posthypoxic polycythemia, and then it was restimulated by bleeding and reexposure to hypoxia. Hemoglobin synthesis was detected with 55Fe incorporation on radioautographs, and its presence was demonstrated in the light microscope with the benzidine reaction and absorption of monochromatic light at λ 4046 Å. In the electron microscope, hemoglobin was detected in the cytoplasm by a general increase in electron density after treating the tissue with diaminobenzidine (DAB) and OsO4. Densitometric measurements were carried out on electronmicroscopic negatives, using reticular cell cytoplasm as a base line. In normal marrow, proerythroblasts were the earliest cells in which hemoglobin could be detected, but during the early phase of erythropoietic stimulation, hemoglobin was demonstrated in transitional cells with all the methods employed. Without the specific demonstration of hemoglobin, these cells could not be recognized morphologically as erythroblasts nor could they be distinguished from the precursors of bone marrow small lymphocytes. Transitional cells were numerous in the marrow at the time of stimulation, and 40 hr later a small number of them were labeled with 55Fe and synthesized hemoglobin in detectable amounts. Proerythroblasts were absent at the time of the stimulus, and when they reappeared the majority were benzidine or DAB positive and had incorporated 55Fe. The findings suggest that progenitor cells of erythroblasts are among the basophilic members of the transitional cell population, and erythropoietic stimulation induces hemoglobin synthesis in them. The relationship of these cells to the progenitors of other hemopoietic cells, as well as to the pluripotent stem cell, is discussed.

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