Whole Blood and Fresh Frozen Plasma: Bacteriological Culture Control

2015 ◽  
pp. 332-336
Author(s):  
Eugene M. Katzin ◽  
Jacob Geiger
Keyword(s):  
Whole Blood ◽  
Fresh Frozen Plasma ◽  
Bacteriological Culture ◽  
Fresh Frozen ◽  
Frozen Plasma

Effect of Whole Blood Storage on Factor VIII Recovery in Fresh Frozen Plasma and Cryoprecipitate

Vox Sanguinis ◽  
1996 ◽  
Vol 71 (3) ◽  
pp. 150-154 ◽  
Author(s):  
D. P. Allersma ◽  
R. M. R. Imambaks ◽  
L. J. Meerhof
Keyword(s):  
Factor Viii ◽  
Whole Blood ◽  
Fresh Frozen Plasma ◽  
Blood Storage ◽  
Fresh Frozen ◽  
Frozen Plasma

EFFECT OF TRANSFUSION OF AUTOLOGOUS WHOLE BLOOD VS. AUTOLOGOUS PACKED RED CELLS AND FRESH FROZEN PLASMA ON THE IMMUNE SYSTEM OF HEALTHY VOLUNTEERS

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 1333A
Author(s):  
Thomas Frietsch ◽  
Heiko Fessler ◽  
Arnulf Lorentz ◽  
Michael Kirschfink ◽  
Klaus F. Waschke
Keyword(s):  
Immune System ◽  
Healthy Volunteers ◽  
Whole Blood ◽  
Fresh Frozen Plasma ◽  
Red Cells ◽  
Autologous Whole Blood ◽  
Fresh Frozen ◽  
Frozen Plasma

Fresh frozen plasma: red blood cells (1:2) coagulation effect is equivalent to 1:1 and whole blood

2015 ◽  
Vol 199 (2) ◽  
pp. 608-614 ◽  
Author(s):  
Joao B. Rezende-Neto ◽  
Gilberto P. Rodrigues ◽  
Thiago A. Lisboa ◽  
Mario Carvalho-Junior ◽  
Maria Julia Silva ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Whole Blood ◽  
Blood Cells ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

Utility of Whole Blood Hemostatometry Using the Clot Signature Analyzer®for Assessment of Hemostasis in Cardiac Surgery

2002 ◽  
Vol 96 (5) ◽  
pp. 1115-1122 ◽  
Author(s):  
Nauder Faraday ◽  
Eliseo Guallar ◽  
Valerie A. Sera ◽  
Everlie D. Bolton ◽  
Robert B. Scharpf ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Whole Blood ◽  
Thrombus Formation ◽  
Fresh Frozen Plasma ◽  
Fibrinogen Concentration ◽  
Plasma Transfusion ◽  
Predictive Values ◽  
Signature Analyzer ◽  
Fresh Frozen ◽  
Frozen Plasma

Background A hemostatic monitor capable of rapid, accurate detection of clinical coagulopathy within the operating room could improve management of bleeding after cardiopulmonary bypass (CPB). The Clot Signature Analyzer is a hemostatometer that measures global hemostasis in whole blood. The authors hypothesized that point-of-care hemostatometry could detect a clinical coagulopathic state in cardiac surgical patients. Methods Fifty-seven adult patients scheduled for a variety of elective cardiac surgical procedures were studied. Anesthesia, CPB, heparin anticoagulation, protamine reversal, and transfusion for post-CPB bleeding were all managed by standardized protocol. Clinical coagulopathy was defined by the need for platelet or fresh frozen plasma transfusion. The Clot Signature Analyzer collagen-induced thrombus formation (CITF) assay measured platelet-mediated hemostasis in vitro. The activated clotting time, platelet count, prothrombin time, activated partial thromboplastin time, and fibrinogen concentration were also measured. Results The postprotamine CITF was greater in patients who required hemostatic transfusion than in those who did not (17.6 +/- 8.0 min vs. 10.5 +/- 5.7 min, respectively; P < 0.01). Postprotamine CITF values were highly correlated with platelet and fresh frozen plasma transfusion (Spearman r = 0.50, P < 0.001 and r = 0.40, P < 0.005, respectively). Receiver operator characteristic curves showed a highly significant relation between the postprotamine CITF and intraoperative platelet and fresh frozen plasma transfusion (area under the curve, 0.78-0.81, P < 0.005) with 60-80% sensitivity, specificity, positive and negative predictive values at cutoffs of 12-14 min. Logistic regression demonstrated that the CITF was independently predictive of post-CPB hemostatic transfusion, but standard hemostatic assays were not. Conclusions The Clot Signature Analyzer CITF detects a clinical coagulopathic state after CPB and is independently predictive of the need for hemostatic transfusion. Hemostatometry has potential utility for monitoring hemostasis in cardiac surgery.

The quality of fresh-frozen plasma produced from whole blood stored at 4°C overnight

Transfusion ◽  
2005 ◽  
Vol 45 (8) ◽  
pp. 1342-1348 ◽  
Author(s):  
Rebecca Cardigan ◽  
Andrew S. Lawrie ◽  
Ian J. Mackie ◽  
Lorna M. Williamson
Keyword(s):  
Whole Blood ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals Concentrated lyophilized plasma used for reconstitution of whole blood leads to higher coagulation factor activity but unchanged thrombin potential compared with fresh-frozen plasma

Transfusion ◽  
2017 ◽  
Vol 57 (7) ◽  
pp. 1763-1771 ◽  
Author(s):  
Giacomo E. Iapichino ◽  
Martin Ponschab ◽  
Janne Cadamuro ◽  
Susanne Süssner ◽  
Christian Gabriel ◽  
...  
Keyword(s):  
Whole Blood ◽  
Coagulation Factor ◽  
Fresh Frozen Plasma ◽  
Factor Activity ◽  
Fresh Frozen ◽  
Frozen Plasma

scholarly journals Stability of Thawed Apheresis Fresh-Frozen Plasma Stored for up to 120 Hours at 1°C to 6°C

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
William P. Sheffield ◽  
Varsha Bhakta ◽  
Qi-Long Yi ◽  
Craig Jenkins
Keyword(s):  
Prothrombin Time ◽  
Closed System ◽  
Whole Blood ◽  
Coagulation Factors ◽  
Fresh Frozen Plasma ◽  
Refrigerated Storage ◽  
Fresh Frozen ◽  
Frozen Plasma ◽  
Over Time ◽  
Made In

Regulations concerning the storage of transfusable plasma differ internationally. In Canada, plasma obtained from whole blood donations and frozen within 24 hours of phlebotomy (frozen plasma, FP) may be thawed and transfused within 120 hours of refrigerated storage. However, plasma frozen within 8 hours of phlebotomy following apheresis donation (FFPA) must be transfused within 24 hours of thawing and refrigeration. Our objectives were to measure coagulation factors (F) V, VII, and VIII, fibrinogen activities, and the prothrombin time (PT) in thawed refrigerated FFPA at 0, 24, and 120 hours of storage and to compare these values to those in thawed refrigerated FP. Fibrinogen activity remained unchanged over time, while mean factor levels in 28 FFPA units declined by 17% (FV), 19.7% (FVII), and 54.6% (FVIII) over 120 hours, while PT values rose to 7.6%. Factor activities were significantly higher in FFPA than FP after 120 hours of refrigerated storage. Residual FVIII activities in thawed FFPA met predefined noninferiority criteria compared to thawed FP after 120 hours. These results support a change in Canadian regulations to permit transfusion of thawed FFPA made in a closed system and refrigerated for up to 120 hours, one that could reduce wastage of transfusable plasma.

Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model

2013 ◽  
Vol 24 (5) ◽  
pp. 489-497 ◽  
Author(s):  
Vadim Kostousov ◽  
Yao-Wei W. Wang ◽  
Bryan A. Cotton ◽  
Charles E. Wade ◽  
John B. Holcomb ◽  
...  
Keyword(s):  
Whole Blood ◽  
Fresh Frozen Plasma ◽  
Fresh Frozen ◽  
Frozen Plasma
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