Acute and Late Side Effects of Radiotherapy for Ocular Disease: An Overview

2015 ◽  
pp. 281-286 ◽  
Author(s):  
W. Alberti
Keyword(s):  
Side Effects ◽  
Ocular Disease ◽  
Late Side Effects ◽  
Late Side

213Acute and late side effects in the adjuvant combined radiation therapy of endometrial carcinoma

1996 ◽  
Vol 40 ◽  
pp. S56
Author(s):  
E. Weiss ◽  
H. Arnold-Bofinger ◽  
N. Weidner ◽  
P. Hirnle ◽  
M. Bamberg
Keyword(s):  
Radiation Therapy ◽  
Side Effects ◽  
Endometrial Carcinoma ◽  
Late Side Effects ◽  
Late Side

1128 Total body irradiation (TBI) before bone marrow grafting (BMG): Analysis of late side effects

1995 ◽  
Vol 31 ◽  
pp. S236
Author(s):  
V. Fayrel ◽  
Th. Schmitt ◽  
J.L. Stephan ◽  
D. Guyotat ◽  
G. Puel ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Side Effects ◽  
Total Body Irradiation ◽  
Late Side Effects ◽  
Total Body ◽  
Bone Marrow Grafting ◽  
Late Side

scholarly journals Late side-effects of valproate and lamotrigine

2007 ◽  
Vol 13 (4) ◽  
pp. 187-189 ◽  
Author(s):  
Bernardo Moreira ◽  
Sigride Thomé-Souza ◽  
Kette Valente
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Seizure Control ◽  
Diagnostic Investigation ◽  
Late Side Effects ◽  
Adolescents And Adults ◽  
Late Adverse Effects ◽  
Generalized Epilepsy ◽  
Late Side ◽  
Chronic Use

Lamotrigine (LTG) is a generally well-tolerated antiepileptic drug with broad-spectrum efficacy in several forms of partial and generalized epilepsy. Adverse effects of lamotrigine are usually associated with introduction and titration. This risk increases in children and in the co-medication with valproate. Herein, we report four patients with late adverse-effects, under the co-medication valproate and LTG, not related to drug introduction or titration. This study demonstrates that late side-effects without apparent etiology in children, adolescents and adults in chronic use of LTG, especially when associated to VPA, led to a diagnostic investigation, sometimes invasive. It must be emphasized that, due to the excellent seizure control, the authors opted for drug decrease instead of drug withdrawal, as previously done. Studies on late adverse effects are scarce, but physicians must be aware of these risks.

Late side-effects with cosmetic relevance following soft X-ray therapy of cutaneous neoplasias

2007 ◽  
Vol 21 (2) ◽  
Author(s):  
R Rupprecht ◽  
A Lippold ◽  
C Auras ◽  
G Bramkamp ◽  
C Breitkopf ◽  
...  
Keyword(s):  
Side Effects ◽  
X Ray ◽  
Late Side Effects ◽  
Late Side

Late side effects of osteosarcoma neoadjuvant chemotherapy: The experience at Rizzoli institute

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 9508-9508 ◽  
Author(s):  
A. Longhi ◽  
S. Ferrari ◽  
C. Ferrari ◽  
M. Cesari ◽  
E. Palmerini ◽  
...  
Keyword(s):  
Side Effects ◽  
Lung Tumor ◽  
Congenital Defects ◽  
Malignant Neoplasms ◽  
Late Side Effects ◽  
Second Malignant Neoplasms ◽  
Second Tumor ◽  
Late Side ◽  
Median Interval

9508 Background: Good cure rate has been reached in osteosarcoma treatment with chemotherapy, but there are late side effects. Methods: We reviewed charts of 755 patients (pts) with localized osteosarcoma of the extremity treated in 6 subsequent protocols (1983–2000) with Doxorubicin (300–480 mg/m2), Cisplatin (300–600 mg/m2), Methotrexate (3.7–75 g/m2), Ifosfamide (30–75 g/m2). Etoposide was employed only in 47 pts. Results: With a median follow up of 8 yrs (5–20), the median 10-yrs EFS was 58%. 13 patients (1.7%), 9 females and 4 males, had a symptomatic cardiopathy with two cardiopathy-related deaths, and 3 patients needed a heart transplant. The median age of these pts was 13 yrs (4–28). Median Doxorubicine dose = 480 mg/m2. Median interval from chemotherapy completion to cardiopathy onset was 3 months; 7 patients are alive, and 6 died: 4 for cardiopathy, 2 for metastatic disease. 17 second malignant neoplasms (SMN) occurred in 16 pts (2.1%) after a median interval of 7 yrs. One patient had both a breast and ovarian cancer. SMN were: 2 AML, 3 ALL, 1 CML, 3 breast cancer, 1 CNS tumor, 1 lung tumor, 1 parotid tumor, 2 soft tissue sarcoma, 1 skin cancer, 1 ovary cancer, 1 Ewing sarcoma. Eight of these 16 pts died of the second tumor. Infertility related to chemotherapy affected mostly males. Amenorrhea affected 69% of postpubertal females during chemotherapy but only two pts had permanent amenorrhea (39 and 43 yrs). No delay in pubertal maturation was seen in both gender. The incidence of infertility in male was related to Ifosfamide and was dose-dependent. Permanent azoospermia was 100% in males who received 60–75g/m2 Ifosfamide. No congenital defects were observed in the offsprings of both gender. The incidence of chronic renal failure was negligible in pts who received <60g/m2 Ifosfamide; in those who received >60 g/m2 a subclinical tubular impairment was observed in 48%, but only 1pt required dialysis. In the last protocol, a mild hearing impairment due to Cisplatin was evident in 40% of pts. Conclusions: Late toxicities are relevant and prolonged follow-ups are recommended as well as less toxic protocols. No significant financial relationships to disclose.

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