Clinical Importance of Radiotherapy in the Treatment of Graves� Disease

2015 ◽  
pp. 195-205 ◽  
Author(s):  
Angelika Friedrich ◽  
Friedrich Kamprad ◽  
Andrea Goldmann
Keyword(s):  
Clinical Importance ◽  
Graves Disease

Prognostic value of thyrotrophin binding inhibiting immunoglobulins (TBII) in longterm antithyroid treatment, 131I therapy given in combination with carbimazole and in euthyroid ophthalmopathy

1981 ◽  
Vol 98 (3) ◽  
pp. 364-369 ◽  
Author(s):  
Henning Bliddal ◽  
Carsten Kirkegaard ◽  
Kaj Siersbæk-Nielsen ◽  
Thorkild Friis
Keyword(s):  
Prognostic Value ◽  
Drug Withdrawal ◽  
Normal Values ◽  
Clinical Importance ◽  
131I Therapy ◽  
Graves Disease ◽  
Prednisone Treatment ◽  
Antithyroid Treatment ◽  
Observation Period

Abstract. Thyrotrophin binding inhibiting immunoglobulins (TBII) were measured in 27 patients with Graves' disease during and after longterm antithyroid treatment. The median observation period after treatment was 24 months. During the first 6 months of treatment the TBII index increased significantly in both the relapse and the remission group, but during the rest of the treatment and the observation no further change was observed. Patients with a TBII index below 0.35 at drug withdrawal (n = 8) all relapsed and patients with values above 1.00 (n = 5) all stayed in remission. There was a significant correlation between the TBII index at drug withdrawal and the time elapsed before a relapse. Graves' disease was treated with 131I in combination with carbimazole in 22 patients. The TBII index of these patients decreased after 131I and increased towards normal values during longterm observation of median 33 months. Of 4 patients with euthyroid ophthalmopathy one was TBII positive. This patient became overt hyperthyroid after an observation period of two years of prednisone treatment. It is concluded, that the TBII index is of some prognostic value after longterm antithyroid treatment, but is of no clinical importance following 131I treatment.

Research Consumerism 101: Evaluating External Evidence of Treatment Effectiveness

2008 ◽  
Vol 17 (2) ◽  
pp. 43-49
Author(s):  
James L. Coyle
Keyword(s):  
Treatment Effectiveness ◽  
Code Of Ethics ◽  
Oropharyngeal Dysphagia ◽  
Clinical Importance ◽  
Professional Services ◽  
Adverse Outcomes ◽  
Professional Judgment ◽  
Evidence Based ◽  
Intervention Selection ◽  
Published Research

Abstract The modern clinician is a research consumer. Rehabilitation of oropharyngeal impairments, and prevention of the adverse outcomes of dysphagia, requires the clinician to select interventions for which evidence of a reasonable likelihood of a successful, important outcome exists. The purpose of this paper is to provide strategies for evaluation of published research regarding treatment of oropharyngeal dysphagia. This article utilizes tutorial and examples to inform and educate practitioners in methods of appraising published research. It provides and encourages the use of methods of efficiently evaluating the validity and clinical importance of published research. Additionally, it discusses the importance of the ethical obligation we, as practitioners, have to use evidence-based treatment selection methods and measurement of patient performance during therapy. The reader is provided with tactics for evaluating treatment studies to establish a study's validity and, thereby, objectively select interventions. The importance of avoiding subjective or unsubstantiated claims and using objective methods of generating empirical clinical evidence is emphasized. The ability to evaluate the quality of research provides clinicians with objective intervention selection as an important, essential component of evidence-based clinical practice. ASHA Code of Ethics (2003): Principle I, Rule F: “Individuals shall fully inform the persons they serve of the nature and possible effects of services rendered and products dispensed…” (p. 2) Principle I, Rule G: “Individuals shall evaluate the effectiveness of services rendered and of products dispensed and shall provide services or dispense products only when benefit can reasonably be expected.” (p. 2) Principle IV, Rule G: “Individuals shall not provide professional services without exercising independent professional judgment, regardless of referral source or prescription.” (p. 4)

Clinical importance of gallstones and p53 mutations in careinogenesis for gallbladder carcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A386-A386
Author(s):  
K HANADA ◽  
F HINO ◽  
H AMANO ◽  
H OOE ◽  
A HIRAMATSU ◽  
...  
Keyword(s):  
Gallbladder Carcinoma ◽  
Clinical Importance ◽  
P53 Mutations

651: The Clinical Importance of Very Small Renal Tumors

2005 ◽  
Vol 173 (4S) ◽  
pp. 177-178
Author(s):  
Heiko Wunderlich ◽  
Alexander Berndt ◽  
Winfried Hindermann ◽  
Kerstin Junker ◽  
Jörg Schubert ◽  
...  
Keyword(s):  
Clinical Importance ◽  
Renal Tumors
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