Genetic Factors in the Aetiology of Non-Insulin-Dependent Diabetes

2015 ◽  
pp. 157-178 ◽  
Author(s):  
Andrew Hattersley
Keyword(s):  
Genetic Factors ◽  
Insulin Dependent Diabetes ◽  
Insulin Dependent

scholarly journals Medicogenetic counseling and prediction of insulin-dependent diabetes mellitus

1996 ◽  
Vol 42 (6) ◽  
pp. 3-8
Author(s):  
T. L. Kuraeva ◽  
O. V. Remizov ◽  
I. I. Dedov
Keyword(s):  
Diabetes Mellitus ◽  
B Cells ◽  
Genetic Predisposition ◽  
Genetic Factors ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Process Stage ◽  
Complete Destruction ◽  
Insulin Dependent

Insulin-dependent diabetes mellitus (IDDM) is a genetically determined disease, in the mechanisms of which autoimmune processes are leading, leading to disruption of insulin production. At present, quite convincing data have been accumulated testifying to the importance of genetic factors in the development of IDDM. Their contribution to the development of the disease (heritability coefficient) is 0.6-0.7, if we take the complete dependence of the development of IDDM on genetic factors as 1.0. The realization of a genetic predisposition in many respects depends on environmental influences that are not yet fully understood. In the development of IDDM, 6 stages are distinguished: stage 1 - a genetic predisposition, stage 2 - a hypothetical starting moment, stage 3 - an active autoimmune process, stage 4 - a decrease in insulin secretion in response to glucose intake, 5 stage I - clinical manifestation, which develops after the death of 80-90% of b-cells, and stage 6 - complete destruction of b-cells. Complete destruction of b-cells, according to some authors, occurs after 5 years or more. Since the development of IDDM is, as a rule, a long multi-stage process that sharply manifests itself at some point, in recent years attempts have been made to predict the development of the disease and verify the asymptomatic preclinical period.

Virologic, immunologic, and genetic factors in insulin-dependent diabetes mellitus

1982 ◽  
Vol 100 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Hervé F. Champsaur ◽  
Gian-Franco Bottazzo ◽  
Jörg Bertrams ◽  
Roger Assan ◽  
Charles Bach
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Factors ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

Factors predicting well-being in adolescents with insulin-dependent diabetes

2002 ◽  
Author(s):  
J. M. Koot ◽  
A. Oldenhave ◽  
G. J. Bruining ◽  
H. J. Aanstoot
Keyword(s):  
Well Being ◽  
Insulin Dependent Diabetes ◽  
Insulin Dependent
Sign in / Sign up

Export Citation Format

Share Document