Clinical Applications of Genetic Studies in Hereditary Colorectal Cancer

2015 ◽  
pp. 173-190
Author(s):  
Shozo Baba
Keyword(s):  
Colorectal Cancer ◽  
Clinical Applications ◽  
Hereditary Colorectal Cancer ◽  
Genetic Studies

scholarly journals Microbial Metabolites in Colorectal Cancer: Basic and Clinical Implications

Metabolites ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 159
Author(s):  
Yao Peng ◽  
Yuqiang Nie ◽  
Jun Yu ◽  
Chi Chun Wong
Keyword(s):  
Colorectal Cancer ◽  
Gut Microbiota ◽  
Cancer Diagnosis ◽  
Intestinal Tract ◽  
Clinical Applications ◽  
Diagnosis And Treatment ◽  
Clinical Implications ◽  
Microbial Metabolites ◽  
Colorectal Tumorigenesis ◽  
Technology Studies

Colorectal cancer (CRC) is one of the leading cancers that cause cancer-related deaths worldwide. The gut microbiota has been proved to show relevance with colorectal tumorigenesis through microbial metabolites. By decomposing various dietary residues in the intestinal tract, gut microbiota harvest energy and produce a variety of metabolites to affect the host physiology. However, some of these metabolites are oncogenic factors for CRC. With the advent of metabolomics technology, studies profiling microbiota-derived metabolites have greatly accelerated the progress in our understanding of the host-microbiota metabolism interactions in CRC. In this review, we briefly summarize the present metabolomics techniques in microbial metabolites researches and the mechanisms of microbial metabolites in CRC pathogenesis, furthermore, we discuss the potential clinical applications of microbial metabolites in cancer diagnosis and treatment.

Application of Multigene Panel Testing In Patients With High Risk for Hereditary Colorectal Cancer

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ji Soo Park ◽  
Jung Won Park ◽  
Saeam Shin ◽  
Seung-Tae Lee ◽  
Sang Joon Shin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Hereditary Colorectal Cancer ◽  
Panel Testing ◽  
Multigene Panel Testing ◽  
Multigene Panel

High-Resolution Melting Analyses for Gene Scanning of APC, MLH1, MSH2, and MSH6 Associated with Hereditary Colorectal Cancer

2012 ◽  
Vol 16 (5) ◽  
pp. 406-411 ◽  
Author(s):  
Jurat Obul ◽  
Sakae Itoga ◽  
Maynur Abliz ◽  
Kenichi Sato ◽  
Takayuki Ishige ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
High Resolution ◽  
High Resolution Melting ◽  
Hereditary Colorectal Cancer ◽  
Gene Scanning

scholarly journals Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies

2018 ◽  
Vol 59 (5-6) ◽  
pp. 361-370 ◽  
Author(s):  
Pridvi Kandagatla ◽  
Lilias H. Maguire ◽  
Karin M. Hardiman
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Molecular Markers ◽  
Lymph Node ◽  
Genetic Heterogeneity ◽  
Genetic Studies ◽  
Potential Models ◽  
Node Metastasis ◽  
Node Metastases ◽  
Nodal Spread

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy.

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