Cutaneous Microdialysis for the Measurement in vivo of the Percutaneous Absorption of Organic Solvents

2015 ◽  
pp. 37-46 ◽  
Author(s):  
C. Anderson ◽  
T. Andersson ◽  
A. Boman ◽  
M. Molander
Keyword(s):  
Organic Solvents ◽  
Percutaneous Absorption

Effect of repeated skin administration on in vivo percutaneous absorption of drugs

1986 ◽  
Vol 115 (s31) ◽  
pp. 49-52 ◽  
Author(s):  
S. COURTHEOUX ◽  
D. PECHENOT ◽  
D.A. BUCKS ◽  
J.P. MARTY ◽  
H.I. MAIBACH ◽  
...  
Keyword(s):  
Percutaneous Absorption ◽  
In Vivo Percutaneous Absorption

Percutaneous absorption of salicylic acid – in vitro and in vivo studies

2014 ◽  
Vol 475 (1-2) ◽  
pp. 471-474 ◽  
Author(s):  
Rita Mateus ◽  
David J. Moore ◽  
Jonathan Hadgraft ◽  
Majella E. Lane
Keyword(s):  
Salicylic Acid ◽  
Percutaneous Absorption ◽  
In Vivo Studies

Percutaneous absorption of methotrexate as its sodium salt in vivo

1987 ◽  
Vol 6 (1) ◽  
pp. 9-12
Author(s):  
N. Bailey David ◽  
Joseph J. Coffee ◽  
R. Briggs John
Keyword(s):  
Sodium Salt ◽  
Percutaneous Absorption

Méthodes de mesure du transfert cutané des radionucléides au travers d'un épiderme intact ou lésé, application à la radiotoxicologie

2002 ◽  
Vol 80 (7) ◽  
pp. 733-741
Author(s):  
H Tymen ◽  
G Rateau ◽  
K Guillet ◽  
B Ramounet-Le Gall ◽  
P Gérasimo ◽  
...  
Keyword(s):  
Percutaneous Absorption ◽  
Experimental Methods ◽  
Industrial Accident ◽  
Common Cause ◽  
The Third ◽  
Nuclear Workers ◽  
Radionuclide Contamination ◽  
Skin Contamination ◽  
Accident Conditions

Although skin contamination by radionuclides is the most common cause of nuclear workers accidents, few studies dealing with the penetration of radioactive contamination through the skin are available. This work is a review of experimental methods that allow to assess transfer of radionuclides through the skin in occupational conditions, with or without skin trauma. The first section describes the different methods applied for skin transfer assessment of chemicals used in pharmacology. Major radionuclide contamination accidents can be associated with skin traumas. Thus, the second section describes the adaptation of these methods to radiotoxicology. Finally, the third section is an in vivo investigation of cobalt transfer (57CoCl2) through undamaged and damaged skin which simulates different industrial accident conditions (excoriation, acid or alcalin burn, scalding, branding).Key words: skin lesion, cobalt, percutaneous absorption, skin radiocontamination, Franz's cell.

scholarly journals ENRICHMENT OF IN VIVO EFFICACY OF CATECHIN RICH EXTRACT WITH THE APPLICATION OF NANOTECHNOLOGY

2018 ◽  
Vol 10 (5) ◽  
pp. 281
Author(s):  
Monika P. ◽  
Basavaraj B. V. ◽  
Chidambara Murthy K. N. ◽  
Ahalya N. ◽  
Bharath S.
Keyword(s):  
Zeta Potential ◽  
Organic Solvents ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Major Elements ◽  
Oral Dosage ◽  
Biological Efficiency ◽  
Evaporation Technique ◽  
Selection Of

Objective: The primary goal of this study was to convert a natural catechin-rich extract into nanoparticles by using a biodegradable and non-toxic polymer Eudragit L 100 to address the various biopharmaceutical problems of catechin.Methods: Nanoparticles were prepared by emulsion solvent evaporation technique using Eudragit L 100 in increasing concentration. Optimization of processing conditions like a selection of organic solvents, diluent and surfactant concentrations, drug and polymer ratio and method of drying to increase the biological efficiency were duly attempted. Parameters such as dynamic light scattering, zeta potential, SEM and energy-dispersive X-ray spectroscopy were assessed for the evaluation of nanoparticles.Results: The entrapment efficiency was found to be between 35-45 % with methanol compared to other organic solvents. The zeta potential values of all the formulations were in the range of±30 mV to±60 mV) which confirms moderate to good stability. A rapid or ‘burst’ effect of the drug release in pH 6.8 buffer showing 92 % in the first 30 min which gradually decreased to 52 % by the end of 180 min but in the pH 7.4, the release was found to be moderate. SEM and DLS indicated particles were of spherical shape lying in a nanometer range of 100 to 200 nm with a proportional influence of polymer on the particles size.Conclusion: Nanoformulations were found to be more stable and confirmed the presence of major elements such as carbon and oxygen. The findings collectively indicate that it may be worthwhile to apply nanotechnology for the design of an advanced oral dosage form for an enhanced bioavailability and biological efficacy.

Sign in / Sign up

Export Citation Format

Share Document