Erythrocyte Cation Transport Systems, Plasma-Inactive Renin and Albuminuria in Insulin-Dependent Diabetics

2015 ◽  
pp. 125-129
Author(s):  
P. Lijnen ◽  
A. Fenyvesi ◽  
V. Petrov
Keyword(s):  
Cation Transport ◽  
Transport Systems ◽  
Insulin Dependent ◽  
Inactive Renin

Erythrocyte Cation Transport Systems and Membrane Lipids in Insulin-Dependent Diabetics

1993 ◽  
Vol 6 (9) ◽  
pp. 763-770 ◽  
Author(s):  
P. Lijnen ◽  
A. Fenyvesi ◽  
M. Bex ◽  
R. Bouillon ◽  
A. Amery
Keyword(s):  
Membrane Lipids ◽  
Cation Transport ◽  
Transport Systems ◽  
Insulin Dependent

[24] Mitochondrial cation transport systems

1995 ◽  
pp. 331-348 ◽  
Author(s):  
Keith D. Garlid ◽  
Xiaocheng Sun ◽  
Peter Paucek ◽  
Gebretateos Woldegiorgis
Keyword(s):  
Cation Transport ◽  
Transport Systems

Sympathetic Nervous Function and Erythrocyte Cation Transport Systems in Normotensive Individuals with Family History of Hyperension

1989 ◽  
Vol 11 (sup1) ◽  
pp. 353-361 ◽  
Author(s):  
Toshihiro Saito ◽  
Yuichiro Koshibu ◽  
Noriyuki Kai ◽  
Kazutoshi Yamamoto ◽  
Jiro Iwata ◽  
...  
Keyword(s):  
Family History ◽  
Cation Transport ◽  
Transport Systems ◽  
Nervous Function ◽  
History Of ◽  
Sympathetic Nervous

scholarly journals Cation transport in Escherichia coli. IX. Regulation of K transport.

1978 ◽  
Vol 72 (3) ◽  
pp. 283-295 ◽  
Author(s):  
D B Rhoads ◽  
W Epstein
Keyword(s):  
Escherichia Coli ◽  
Steady State ◽  
Cation Transport ◽  
Transport Systems ◽  
Energy Requirements ◽  
Protonmotive Force ◽  
K Uptake ◽  
Kinetics Of ◽  
K Transport ◽  
External K

Kinetics of K exchange in the steady state and of net K uptake after osmotic upshock are reported for the four K transport systems of Escherichia coli: Kdp, TrkA, TrkD, and TrkF. Energy requirements for K exchange are reported for the Kdp and TrkA systems. For each system, kinetics of these two modes of K transport differ from those for net K uptake by K-depleted cells (Rhoads, D. B. F.B. Walters, and W. Epstein. 1976. J. Gen. Physiol. 67:325-341). The TrkA and TrkD systems are inhibited by high intracellular K, the TrkF system is stimulated by intracellular K, whereas the Kdp system is inhibited by external K when intracellular K is high. All four systems mediate net K uptake in response to osmotic upshock. Exchange by the Kdp and TrkA systems requires ATP but is not dependent on the protonmotive force. Energy requirements for the Kdp system are thus identical whether measured as net K uptake or K exchange, whereas the TrkA system differs in that it is dependent on the protonmotive force only for net K uptake. We suggest that in both the Kpd and TrkA systems formation of a phosphorylated intermediate is necessary for all K transport, although exchange transport may not consume energy. The protonmotive-force dependence of the TrkA system is interpreted as a regulatory influence, limiting this system to exchange except when the protonmotive force is high.

scholarly journals Inorganic Cation Transport and Energy Transduction in Enterococcus hirae and Other Streptococci

1998 ◽  
Vol 62 (4) ◽  
pp. 1021-1045 ◽  
Author(s):  
Yoshimi Kakinuma
Keyword(s):  
Driving Force ◽  
Cation Transport ◽  
Energy Transduction ◽  
Transport Systems ◽  
Transmembrane Transport ◽  
Cytoplasmic Ph ◽  
Enterococcus Hirae ◽  
Proton Potential ◽  
Inorganic Cation ◽  
Respiratory Chains

SUMMARY Energy metabolism by bacteria is well understood from the chemiosmotic viewpoint. We know that bacteria extrude protons across the plasma membrane, establishing an electrochemical potential that provides the driving force for various kinds of physiological work. Among these are the uptake of sugars, amino acids, and other nutrients with the aid of secondary porters and the regulation of the cytoplasmic pH and of the cytoplasmic concentration of potassium and other ions. Bacteria live in diverse habitats and are often exposed to severe conditions. In some circumstances, a proton circulation cannot satisfy their requirements and must be supplemented with a complement of primary transport systems. This review is concerned with cation transport in the fermentative streptococci, particularly Enterococcus hirae. Streptococci lack respiratory chains, relying on glycolysis or arginine fermentation for the production of ATP. One of the major findings with E. hirae and other streptococci is that ATP plays a much more important role in transmembrane transport than it does in nonfermentative organisms, probably due to the inability of this organism to generate a large proton potential. The movements of cations in streptococci illustrate the interplay between a variety of primary and secondary modes of transport.

Red Cell Transport Abnormalities As Predictors of the Development of Renal Disease in Children with Sickle Cell Disease

Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 1317-1317
Author(s):  
Sanjay Tewari ◽  
John Gibson ◽  
Stephan Menzel ◽  
Anke Hannemann ◽  
Swee Lay Thein ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Conflicts Of Interest ◽  
Cation Transport ◽  
Transport Systems ◽  
Common Finding ◽  
Early Event ◽  
Cell Disease ◽  
College Hospital ◽  
Transport Pathways

Abstract Background: Patients with sickle cell disease (SCD) have the abnormal haemoglobin (Hb) HbS in their red blood cells (RBCs). The complications of SCD may be extensive but are markedly variable between patients. Renal damage (sometimes called sickle cell nephropathy, SCN) is a common finding in about a third of children with SCD, a significant number of whom will proceed to renal failure. As yet, it is not possible to predict which children will develop SCN and who would therefore benefit from earlier and aggressive management. Various biomarkers have been investigated but none have proved efficacious. Changes in RBC membrane permeability are closely linked with polymerisation of HbS and, as such, may represent an important early event in pathogenesis. We postulated that certain RBC characteristics (sickling, K+ transport, PS exposure), which may be inherited independently of the HbS mutation, may correlate with renal pathology, but more importantly, may be identifiable in advance of damage, thereby providing prognostic markers to inform patient management. Participants and Methods: Children (>4 years old) with sickle cell anaemia (SCA) were recruited from the paediatric haematology clinic at King's College Hospital in South London, UK. Patients who had received blood transfusion in the preceding four months or who were on medications known to directly alter RBC cation transport (e.g. dipyridamole and Ca2+ channel blockers) were excluded. Patients on hydroxyurea were included. All patients were in steady state, with no acute symptoms requiring treatment for at least seven days. Clinical and laboratory parameters were collected prospectively at routine clinical attendance. Details of enuresis were collected using specifically developed proforma and patients were divided into two groups: those who stopped wetting their bed before the age of five years and those who were still enuretic after five years of age. RBC permeability was assessed using 86Rb+ as a congener for K+ to measure the activity of main cation transport systems involved in RBC dehydration. The activity of RBC transport pathways and percentage of sickling was measured at 100mmHg, 35mmHg, 15mmHg and 0mmHg. Statistical analysis was conducted using IBM-SPSS, New York. Results: 112 patients of HbSS genotype (SCA) consented to take part in the study. Their clinical profile is summarised Table 1. The percentage of children with enuresis, hypertension and significant albuminuria is shown in Table 2. There was significant correlation between activity of Gardos channel at O2 tensions of 35mmHg, 15mmHg and 0mmHg and enuresis after the age of five years. Psickle activity also showed significant correlation but only in fully deoxygenated RBCs (O2 of 0mmHg.) Table 3. Conclusion In conclusion, the present findings emphasise the significance of a thorough appreciation of RBC permeability to the pathogenesis of SCD. Whilst preliminary, these findings are exciting because they show that the activity of a particular transport pathways, abnormally elevated in SCA patients, are associated with enuresis. These findings suggest that the early identification of increased Gardos and Psickle activity may identify children who would benefit from early treatment for nocturnal enuresis. Disclosures No relevant conflicts of interest to declare.

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