Desensitization of Histamine H1 Receptors in Smooth Muscle

2015 ◽  
pp. 95-105
Author(s):  
Shuhei Horio ◽  
Tetsuhiro Hisayama ◽  
Hideki Moritoki
Keyword(s):  
Smooth Muscle ◽  
Histamine H1 Receptors

Specific binding of 3H-mepyramine to histamine H1 receptors in intestinal smooth muscle

Nature ◽  
1977 ◽  
Vol 270 (5635) ◽  
pp. 361-363 ◽  
Author(s):  
S. J. HILL ◽  
J. M. YOUNG ◽  
D. H. MARRIAN
Keyword(s):  
Smooth Muscle ◽  
Specific Binding ◽  
Intestinal Smooth Muscle ◽  
Histamine H1 Receptors

Histamine H1-receptors mediate phosphoinositide and calcium response in cultured smooth muscle cells-interaction with cicletanine (CIC)

1988 ◽  
Vol 24 (3-4) ◽  
pp. 255-260 ◽  
Author(s):  
M. O. Lonchampt ◽  
P. Marche ◽  
C. Demerle ◽  
A. Girard ◽  
M. Cabanie ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Calcium Response ◽  
Cultured Smooth Muscle Cells ◽  
Histamine H1 Receptors

Distribution of histamine receptors in isolated canine airways

1983 ◽  
Vol 54 (3) ◽  
pp. 693-700 ◽  
Author(s):  
S. L. Bradley ◽  
J. A. Russell
Keyword(s):  
Smooth Muscle ◽  
Histamine Receptors ◽  
Receptor Activity ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
H2 Antagonist ◽  
Histamine H1 Receptors ◽  
H1 Antagonist ◽  
Dose Dependent

The distribution of histamine receptors was examined in isolated trachealis smooth muscle strips and helical strips of large (5 mm) and small (1.5 mm) intrapulmonary airways. All airways contracted in response to histamine, but the sensitivity to this agent was significantly greater in intrapulmonary airways than in trachealis strips. A dose-dependent tachyphylaxis to histamine occurred when airways were exposed repeatedly to 10(-4) M histamine but not to 5 X 10(-6) M histamine. The H1-agonist, 2-methylhistamine, also caused airway contractions, although they were less forceful than those caused by histamine. Both histamine- and 2-methylhistamine-induced contractions were blocked by the H1-antagonist, pyrilamine. The H2-agonists, 4-methylhistamine and dimaprit, as well as histamine in the presence of pyrilamine failed to relax both acetylcholine- and 5-hydroxytryptamine-induced contractions. Moreover, the H2-antagonist, metiamide, had no effect on histamine-induced contractions. We conclude that histamine H1-receptors are present in both extrapulmonary and intrapulmonary airways of the dog and cause contraction when stimulated. In contrast, histamine H2-receptor activity could not be demonstrated in the airways of this species.

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