The HIV-1 Regulatory Genes tat and rev as Targets for Gene Therapy1

2015 ◽  
pp. 205-216 ◽  
Author(s):  
Antonella Caputo ◽  
Cristina Rossi ◽  
Pier Giorgio Balboni ◽  
Roberta Bozzini ◽  
Maria Pia Grossi ◽  
...  
Keyword(s):  
Regulatory Genes ◽  
Hiv 1

scholarly journals HIV-1 regulatory genes and their role in the viral genome realization

1994 ◽  
Vol 10 (5) ◽  
pp. 5-30
Author(s):  
A. P. Kukharenko ◽  
A. D. Shved
Keyword(s):  
Viral Genome ◽  
Regulatory Genes ◽  
Hiv 1

Site-directed mutagenesis of two trans-regulatory genes (tat-III,trs) of HIV-1

Science ◽  
1988 ◽  
Vol 239 (4842) ◽  
pp. 910-913 ◽  
Author(s):  
M. Sadaie ◽  
T Benter ◽  
F Wong-Staal
Keyword(s):  
Regulatory Genes ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Hiv 1

scholarly journals Identification of key immune regulatory genes in HIV-1 progression

Gene ◽  
2021 ◽  
pp. 145735
Author(s):  
Sk Md Mosaddek Hossain ◽  
Lutfunnesa Khatun ◽  
Sumanta Ray ◽  
Anirban Mukhopadhyay
Keyword(s):  
Regulatory Genes ◽  
Hiv 1

scholarly journals Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

2007 ◽  
Vol 3 (7) ◽  
pp. e94 ◽  
Author(s):  
Zabrina L Brumme ◽  
Chanson J Brumme ◽  
David Heckerman ◽  
Bette T Korber ◽  
Marcus Daniels ◽  
...  
Keyword(s):  
Viral Evolution ◽  
Hla Class I ◽  
Regulatory Genes ◽  
Class I ◽  
Hiv 1

scholarly journals Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

2007 ◽  
Vol 3 (8) ◽  
pp. e121 ◽  
Author(s):  
Zabrina L. Brumme ◽  
Chanson J. Brumme ◽  
David Heckerman ◽  
Bette T. Korber ◽  
Marcus Daniels ◽  
...  
Keyword(s):  
Viral Evolution ◽  
Hla Class I ◽  
Regulatory Genes ◽  
Class I ◽  
Hiv 1

Retrovirus Vector-Mediated Transfer of Functional HIV-1 Regulatory Genes

1994 ◽  
Vol 10 (1) ◽  
pp. 47-52 ◽  
Author(s):  
J. VICTOR GARCIA ◽  
A. DUSTY MILLER
Keyword(s):  
Regulatory Genes ◽  
Retrovirus Vector ◽  
Hiv 1

scholarly journals Evolutionary dynamics of HIV-1 subtype C accessory and regulatory genes in primary infection

Retrovirology ◽  
2012 ◽  
Vol 9 (S2) ◽  
Author(s):  
R Rossenkhan ◽  
V Novitsky ◽  
TK Sebunya ◽  
R Musonda ◽  
BA Gashe ◽  
...  
Keyword(s):  
Primary Infection ◽  
Evolutionary Dynamics ◽  
Regulatory Genes ◽  
Subtype C ◽  
Hiv 1

scholarly journals Identification of key immune regulatory genes in HIV–1 Progression

2020 ◽  
Author(s):  
Sk Md Mosaddek Hossain ◽  
Lutfunnesa Khatun ◽  
Sumanta Ray ◽  
Anirban Mukhopadhyay
Keyword(s):  
Differentially Expressed Genes ◽  
Permutation Test ◽  
Biological Significance ◽  
Microarray Gene Expression Data ◽  
Regulatory Genes ◽  
Differentially Expressed ◽  
Microarray Gene Expression ◽  
Module Preservation ◽  
The Difference ◽  
Hiv 1

AbstractIn the last few decades, application of DNA microarray technology has sprung up as a powerful technique for discovering stage specific changes in expression pattern of a disease progression. Human Immunodeficiency Virus (HIV) infection causes Acquired Immunodeficiency Syndrome (AIDS) which is one of the most devastating diseases affecting humankind. Here, we have proposed a framework to examine the difference among microarray gene expression data of uninfected and three different HIV–1 infection stages using module preservation statistics. Initially, we detected differentially expressed genes among all the stages and identified coexpression modules by using topological overlap as a dissimilarity measure. To examine relationship among co-expression modules, we have compiled a module eigenegene network for each sample category which models similarity among all coexpression modules. To further examine the network, we have found clusters in it which are termed as ‘meta-modules’. Different module preservation statistics with two composite statistics: “Zsummary” and “MedianRank” are utilized to examine changes in structure of coexpression modules. We have applied our proposed methodology to discover modular changes between uninfected and acute samples, acute and chronic samples, chronic and AIDS samples. We have found several interesting results on preservation characteristics of gene modules across different stages. Some genes are identified to be preserved in a pair of stages while alter their characteristics across other stages. We further validated the obtained results using permutation test and classification techniques. Biological significance of the obtained modules have been examined using gene ontology and pathway based analysis. Additionally, we have detected key immune regulatory hub genes in the associated protein-protein interaction networks (PPINs) of the differentially expressed genes (DEGs) using twelve topological and centrality analysis methods. Moreover, we have analyzed the key immune regulatory genes which interacts with HIV-1 proteins inside the preserved and perturbed meta-modules across different HIV-1 stages and thus likely to act as potential biomarkers in HIV–1 progression.

Sign in / Sign up

Export Citation Format

Share Document