Th Cell Development and Regulation in Experimental Cutaneous Leishmaniasis

2015 ◽  
pp. 98-114 ◽  
Author(s):  
Phillip Scott
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Cell Development ◽  
Th Cell

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

Blood ◽  
1998 ◽  
Vol 92 (9) ◽  
pp. 3338-3345 ◽  
Author(s):  
Yusei Ohshima ◽  
Liang-Peng Yang ◽  
Takashi Uchiyama ◽  
Yuetsu Tanaka ◽  
Peter Baum ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Primary Cultures ◽  
Tumor Necrosis Factor Receptor ◽  
Cell Development ◽  
Interleukin 4 ◽  
Effector Cells ◽  
Cellular Origin ◽  
Th Cell ◽  
American Society

Th2 cell development is critically dependent on the presence of interleukin-4 (IL-4) at priming. The cellular origin and the mechanisms regulating this early production of IL-4 at the site of naive T-cell priming are extensively investigated. We previously reported that anti-CD3–activated and CD28-costimulated naive human CD4+ T cells themselves release very low but sufficient levels of IL-4 to support their development into high IL-4–producing cells. We show here that ligation of OX40 Ag, a member of the tumor necrosis factor receptor (TNF-R) family, on activated umbilical cord blood CD4+ T cells upregulates IL-4 production at priming and thereby promotes their development into effector cells producing high levels of the type 2 cytokines IL-4, IL-5, and IL-13. OX40 ligation increases four times the expression of IL-4 mRNA after 48 hours of anti-CD3/B7.1 activation and significantly augments the release of IL-4 and IL-13 in primary cultures. The effects of OX40 costimulation on Th cell differentiation are observed in the presence of optimal and suboptimal CD28 stimulation. Because OX40 ligand is expressed on dendritic cells, the OX40 costimulation pathway may be involved in the physiological regulation of Th cell development by augmenting the differentiation of IL-4–producing cells. © 1998 by The American Society of Hematology.

scholarly journals Th1 Cell Development Induced by Cysteine Proteinases A and B in Localized Cutaneous Leishmaniasis Due to Leishmania guyanensis

2003 ◽  
Vol 71 (5) ◽  
pp. 2924-2926 ◽  
Author(s):  
Hervé Pascalis ◽  
Anne Lavergne ◽  
Eliane Bourreau ◽  
Ghislaine Prévot-Linguet ◽  
Amina Kariminia ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Leishmania Major ◽  
Cell Development ◽  
Interleukin 4 ◽  
Cysteine Proteinases ◽  
Th1 Cell ◽  
Low Levels ◽  
Leishmania Guyanensis

ABSTRACT The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.

scholarly journals Marked Induction of c-Maf Protein during Th17 Cell Differentiation and Its Implication in Memory Th Cell Development

2011 ◽  
Vol 286 (17) ◽  
pp. 14963-14971 ◽  
Author(s):  
Kojiro Sato ◽  
Fumihiko Miyoshi ◽  
Kazuhiro Yokota ◽  
Yasuto Araki ◽  
Yu Asanuma ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Th17 Cell ◽  
Cell Development ◽  
Th Cell ◽  
Th17 Cell Differentiation

Quantities of Interleukin-12p40 in Mature CD8α Negative Dendritic Cells Correlate with Strength of TCR Signal and Determine Th Cell Development

2003 ◽  
Vol 47 (12) ◽  
pp. 1017-1024 ◽  
Author(s):  
Noriki Fujimoto ◽  
Hideaki Ishida ◽  
Ichiro Nakamura ◽  
Kazumasa Ogasawara ◽  
Yasushi Itoh
Keyword(s):  
Dendritic Cells ◽  
Cell Development ◽  
Th Cell

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

Blood ◽  
1998 ◽  
Vol 92 (9) ◽  
pp. 3338-3345 ◽  
Author(s):  
Yusei Ohshima ◽  
Liang-Peng Yang ◽  
Takashi Uchiyama ◽  
Yuetsu Tanaka ◽  
Peter Baum ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Primary Cultures ◽  
Tumor Necrosis Factor Receptor ◽  
Cell Development ◽  
Interleukin 4 ◽  
Effector Cells ◽  
Cellular Origin ◽  
Th Cell ◽  
American Society

Abstract Th2 cell development is critically dependent on the presence of interleukin-4 (IL-4) at priming. The cellular origin and the mechanisms regulating this early production of IL-4 at the site of naive T-cell priming are extensively investigated. We previously reported that anti-CD3–activated and CD28-costimulated naive human CD4+ T cells themselves release very low but sufficient levels of IL-4 to support their development into high IL-4–producing cells. We show here that ligation of OX40 Ag, a member of the tumor necrosis factor receptor (TNF-R) family, on activated umbilical cord blood CD4+ T cells upregulates IL-4 production at priming and thereby promotes their development into effector cells producing high levels of the type 2 cytokines IL-4, IL-5, and IL-13. OX40 ligation increases four times the expression of IL-4 mRNA after 48 hours of anti-CD3/B7.1 activation and significantly augments the release of IL-4 and IL-13 in primary cultures. The effects of OX40 costimulation on Th cell differentiation are observed in the presence of optimal and suboptimal CD28 stimulation. Because OX40 ligand is expressed on dendritic cells, the OX40 costimulation pathway may be involved in the physiological regulation of Th cell development by augmenting the differentiation of IL-4–producing cells. © 1998 by The American Society of Hematology.

scholarly journals OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection

2016 ◽  
Vol 198 (1) ◽  
pp. 218-228 ◽  
Author(s):  
Vikas Tahiliani ◽  
Tarun E. Hutchinson ◽  
Georges Abboud ◽  
Michael Croft ◽  
Shahram Salek-Ardakani
Keyword(s):  
Germinal Center ◽  
Cell Development ◽  
Th Cell
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