Hyaluronic Acid as a Molecular Filter and Friction-Reducing Lubricant in the Human Inner Ear

2015 ◽  
pp. 82-86
Author(s):  
Matti Anniko ◽  
Wolfgang Arnold
Keyword(s):  
Hyaluronic Acid ◽  
Inner Ear ◽  
Friction Reducing ◽  
Human Inner Ear

Hyaluronic Acid as a Molecular Filter and Friction-Reducing Lubricant in the Human Inner Ear

ORL ◽  
1995 ◽  
Vol 57 (2) ◽  
pp. 82-86 ◽  
Author(s):  
Matti Anniko ◽  
Wolfgang Arnold
Keyword(s):  
Hyaluronic Acid ◽  
Inner Ear ◽  
Friction Reducing ◽  
Human Inner Ear

scholarly journals A Human Inner Ear Model for assessment of Noise Induced Hearing Loss via energy methods

2020 ◽  
Vol 53 (2) ◽  
pp. 16424-16429
Author(s):  
Milka C.I. Madahana ◽  
Otis T.C. Nyandoro ◽  
John E.D. Ekoru
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Energy Methods ◽  
Noise Induced Hearing Loss ◽  
Human Inner Ear

Cytomegalovirus Isolation from a Human Inner Ear

1979 ◽  
Vol 88 (3) ◽  
pp. 424-426 ◽  
Author(s):  
Larry E. Davis ◽  
Charles G. James ◽  
Frederick Fiber ◽  
Leroy C. McLaren
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Congenital Deafness ◽  
Cmv Infection ◽  
Human Inner Ear ◽  
Congenital Cmv

Cytomegalovirus (CMV) infection of the fetus has been associated with congenital deafness or hearing loss. This association has previously been based on clinical or pathological studies. We report an infant who died with the congenital CMV syndrome in which CMV was isolated from the perilymph of the inner ear providing additional evidence that this virus can infect the labyrinth.

scholarly journals Deafness-in-a-dish: modeling hereditary deafness with inner ear organoids

2021 ◽  
Author(s):  
Daniel R. Romano ◽  
Eri Hashino ◽  
Rick F. Nelson
Keyword(s):  
Animal Models ◽  
Inner Ear ◽  
Auditory System ◽  
Hearing Aids ◽  
Molecular Mechanisms ◽  
Functional Disability ◽  
Experimental Studies ◽  
Hereditary Deafness ◽  
Human Auditory System ◽  
Human Inner Ear

AbstractSensorineural hearing loss (SNHL) is a major cause of functional disability in both the developed and developing world. While hearing aids and cochlear implants provide significant benefit to many with SNHL, neither targets the cellular and molecular dysfunction that ultimately underlies SNHL. The successful development of more targeted approaches, such as growth factor, stem cell, and gene therapies, will require a yet deeper understanding of the underlying molecular mechanisms of human hearing and deafness. Unfortunately, the human inner ear cannot be biopsied without causing significant, irreversible damage to the hearing or balance organ. Thus, much of our current understanding of the cellular and molecular biology of human deafness, and of the human auditory system more broadly, has been inferred from observational and experimental studies in animal models, each of which has its own advantages and limitations. In 2013, researchers described a protocol for the generation of inner ear organoids from pluripotent stem cells (PSCs), which could serve as scalable, high-fidelity alternatives to animal models. Here, we discuss the advantages and limitations of conventional models of the human auditory system, describe the generation and characteristics of PSC-derived inner ear organoids, and discuss several strategies and recent attempts to model hereditary deafness in vitro. Finally, we suggest and discuss several focus areas for the further, intensive characterization of inner ear organoids and discuss the translational applications of these novel models of the human inner ear.

P122. Multimodal probabilistic atlas of the human inner ear enables an automated and reliable segmentation of the endolymphatic space

2018 ◽  
Vol 129 (8) ◽  
pp. e112-e113
Author(s):  
F. Nejatbakhshesfahani ◽  
V. Kirsch ◽  
A. Berman ◽  
D. Keeser ◽  
A. Ahmadi ◽  
...  
Keyword(s):  
Inner Ear ◽  
Probabilistic Atlas ◽  
Human Inner Ear ◽  
Endolymphatic Space

scholarly journals Generation of human inner ear prosensory-like cells via epithelial-to-mesenchymal transition

2012 ◽  
Vol 7 (5) ◽  
pp. 663-673 ◽  
Author(s):  
Zhengqing Hu ◽  
Xuemei Luo ◽  
Lei Zhang ◽  
Fengqing Lu ◽  
Fengping Dong ◽  
...  
Keyword(s):  
Inner Ear ◽  
Epithelial To Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Human Inner Ear
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