Influence of Coagulation Parameters on Filter Running Time during Continuous Venovenous Hemofiltration

2015 ◽  
pp. 145-149 ◽  
Author(s):  
Ioannis Stefanidis ◽  
Johannes H�gel ◽  
Norbert Maurin
Keyword(s):  
Continuous Venovenous Hemofiltration ◽  
Running Time ◽  
Coagulation Parameters

Plasma Thrombin Assay using a Chromogenic Substrate in Disseminated Intravascular Coagulation due to Snake Bite Envenomation

1979 ◽  
Vol 41 (03) ◽  
pp. 544-552 ◽  
Author(s):  
R P Herrmann ◽  
P E Bailey
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Degradation Products ◽  
Snake Bite ◽  
Chromogenic Substrate ◽  
Coagulation Parameters ◽  
Fibrinogen Degradation Products ◽  
Intravascular Coagulation

SummaryUsing the chromogenic substrate, Tos-Gly-Pro-Arg-pNA-HCL (Chromozym TH, Boehringer Mannheim) plasma thrombin was estimated in six cases of envenomation by Australian elapid snakes. All patients manifested findings chracteristic of defibrination due to envenomation by these snakes. Fibrin-fibrinogen degradation products were grossly elevated, as was plasma thrombin in all cases.Following treatment with antivenene, all abnormal coagulation parameters returned rapidly towards normal by 24 hours and plasma thrombin disappeared.

A Comparative Ex Vivo Study of Plasminogen Activators and Proteases for Fibrinolytic Activity and Side Effects in Rabbits

1977 ◽  
Vol 37 (01) ◽  
pp. 154-161 ◽  
Author(s):  
B. A Janik ◽  
S. E Papaioannou
Keyword(s):  
Side Effects ◽  
Effective Dose ◽  
Fibrinolytic Activity ◽  
Ex Vivo ◽  
Plasminogen Activators ◽  
Assay System ◽  
Coagulation Parameters ◽  
Ex Vivo Assay

SummaryUrokinase, streptokinase, Brinase, trypsin, and SN 687, a bacterial exoprotease, have been evaluated in an ex vivo assay system. These enzymes were injected into rabbits and the fibrinolytic activity as well as other coagulation parameters were measured by in vitro techniques. Dose-response correlations have been made using the euglobulin lysis time as a measure of fibrinolytic activity and the 50% effective dose has been determined for each enzyme. Loading doses, equal to four times the 50% effective dose, were administered to monitor potential toxicity revealing that Brinase, trypsin, and SN 687 were very toxic at this concentration.Having established the 50% effective dose for each enzyme, further testing was conducted where relevant fibrinolytic and coagulation parameters were measured for up to two days following a 50% effective dose bolus injection of each enzyme. Our results have demonstrated that urokinase and streptokinase are plasminogen activators specifically activating the rabbit fibrinolytic system while Brinase, trypsin and SN 687 increase the general proteolytic activity in vivo.The advantages of this ex vivo assay system for evaluating relative fibrinolytic potencies and side effects for plasminogen activators and fibrinolytic proteases have been discussed.

Effects of Human Antithrombin III on Mortality and Blood Coagulation Induced in Rabbits by Endotoxin

1984 ◽  
Vol 51 (02) ◽  
pp. 232-235 ◽  
Author(s):  
D C Triantaphyllopoulos
Keyword(s):  
Blood Coagulation ◽  
Bolus Dose ◽  
Antithrombin Iii ◽  
Coagulation Parameters ◽  
E Coli ◽  
At Iii ◽  
Baseline Values

SummaryTwenty-one rabbits were infused with 20μg/kg/hr of E. coli endotoxin for 6 hr. Eight of the animals were preinjected immediately before the infusion of endotoxin, with a bolus dose of human AT III calculated to increase the antithrombin content of the plasma by about 4 units/ml. All eight animals which were preinjected with AT III survived, while 5 of the 13 control rabbits infused with endotoxin alone died. The changes in coagulation parameters from the baseline values, between the 8 control rabbits which survived and the 8 animals which were preinjected with AT III were compared. The concentration of the preinjected human AT III declined significantly faster (P: <0.01) than that of the native rabbit AT III. AT III prevented the decline of F.XII throughout the infusion of the endotoxin. However, the decline in F.V, fibrinogen, prothrombin and platelets was not affected (P: >0.5) by the injection of AT III.

Coagulation parameters and platelet function analysis in patients with acromegaly

2015 ◽  
Author(s):  
Hamiyet Yilmaz Yasar ◽  
Mustafa Demirpence ◽  
Ayfer Colak ◽  
Banu Ozturk Ceyhan ◽  
Yusuf Temel ◽  
...  
Keyword(s):  
Platelet Function ◽  
Function Analysis ◽  
Coagulation Parameters

TEM Sample Prep Tool Matching—DualBeam FIB Cut Look and Measure Monitoring for Process Control and Development in a 300 mm IC Fab

2016 ◽  
Author(s):  
Jangbae Jeon
Keyword(s):  
Process Control ◽  
Sample Preparation ◽  
Continuous Improvement ◽  
Process Time ◽  
Operational Monitoring ◽  
Thickness Control ◽  
Running Time ◽  
End Products ◽  
Novel Method

Abstract This work presents a novel method of continuous improvement for faster, better and cheaper TEM sample preparation using Cut Look and Measure (CLM). The improvement of the process is executed by operational monitoring of daily beam conditions, end products, bulk thickness control, recipe usage and tool running time. This process produces a consequent decrease in rework rate and process time. In addition, it also increases throughput with better quality TEM samples.

Best Neighbor Heuristic Search for Finding Minimum Paths in Transportation Networks

1998 ◽  
Vol 1651 (1) ◽  
pp. 48-52 ◽  
Author(s):  
Jeffrey L. Adler
Keyword(s):  
Heuristic Search ◽  
Transportation Networks ◽  
Transportation Network ◽  
Search Problems ◽  
A Algorithm ◽  
Running Time ◽  
Search Effort ◽  
Wide Range ◽  
Path Search ◽  
Sparse Networks

For a wide range of transportation network path search problems, the A* heuristic significantly reduces both search effort and running time when compared to basic label-setting algorithms. The motivation for this research was to determine if additional savings could be attained by further experimenting with refinements to the A* approach. We propose a best neighbor heuristic improvement to the A* algorithm that yields additional benefits by significantly reducing the search effort on sparse networks. The level of reduction in running time improves as the average outdegree of the network decreases and the number of paths sought increases.

Ultrashort pulses propagation through different approaches of the Split-Step Fourier method

2018 ◽  
Vol 1 (3) ◽  
pp. 2
Author(s):  
José Stênio De Negreiros Júnior ◽  
Daniel Do Nascimento e Sá Cavalcante ◽  
Jermana Lopes de Moraes ◽  
Lucas Rodrigues Marcelino ◽  
Francisco Tadeu De Carvalho Belchior Magalhães ◽  
...  
Keyword(s):  
Energy Conservation ◽  
Optical Pulse ◽  
Time Window ◽  
Fourier Method ◽  
Ultrashort Pulses ◽  
Nonlinear Effects ◽  
Single Mode ◽  
Time Algorithm ◽  
Optical Pulses ◽  
Running Time

Simulating the propagation of optical pulses in a single mode optical fiber is of fundamental importance for studying the several effects that may occur within such medium when it is under some linear and nonlinear effects. In this work, we simulate it by implementing the nonlinear Schrödinger equation using the Split-Step Fourier method in some of its approaches. Then, we compare their running time, algorithm complexity and accuracy regarding energy conservation of the optical pulse. We note that the method is simple to implement and presents good results of energy conservation, besides low temporal cost. We observe a greater precision for the symmetrized approach, although its running time can be up to 126% higher than the other approaches, depending on the parameters set. We conclude that the time window must be adjusted for each length of propagation in the fiber, so that the error regarding energy conservation during propagation can be reduced.

scholarly journals Improved Cardiovascular Tolerance to Hemorrhage after Oral Resveratrol Pretreatment in Dogs

2021 ◽  
Vol 8 (7) ◽  
pp. 129
Author(s):  
Jennifer Davis ◽  
Anthea L. Raisis ◽  
Claire R. Sharp ◽  
Rachel E. Cianciolo ◽  
Steven C. Wallis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Placebo Group ◽  
Blood Loss ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Kidney Injury ◽  
Bleeding Risk ◽  
Canine Model ◽  
Coagulation Parameters ◽  
Renal Tubular

Resveratrol has been shown to preserve organ function and improve survival in hemorrhagic shock rat models. This study investigated whether seven days of oral resveratrol could improve hemodynamic response to hemorrhage and confer benefits on risk of acute kidney injury (AKI) without inducing coagulopathy in a canine model. Twelve greyhound dogs were randomly allocated to receive oral resveratrol (1000 mg/day) or placebo for seven days prior to inducing hemorrhage until a targeted mean blood pressure of ≤40 mmHg was achieved. AKI biomarkers and coagulation parameters were measured before, immediately following, and two hours after hemorrhage. Dogs were euthanized, and renal tissues were examined at the end of the experiment. All investigators were blinded to the treatment allocation. A linear mixed model was used to assess effect of resveratrol on AKI biomarkers and coagulation parameters while adjusting for volume of blood loss. A significant larger volume of blood loss was required to achieve the hypotension target in the resveratrol group compared to placebo group (median 64 vs. 55 mL/kg respectively, p = 0.041). Although histological evidence of AKI was evident in all dogs, the renal tubular injury scores were not significantly different between the two groups, neither were the AKI biomarkers. Baseline (pre-hemorrhage) maximum clot firmness on the Rotational Thromboelastometry (ROTEM®) was stronger in the resveratrol group than the placebo group (median 54 vs. 43 mm respectively, p = 0.009). In summary, seven days of oral resveratrol did not appear to induce increased bleeding risk and could improve greyhound dogs’ blood pressure tolerance to severe hemorrhage. Renal protective effect of resveratrol was, however, not observed.

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