Role of Mast Cells in Atherosclerosis

2015 ◽  
pp. 132-170 ◽  
Author(s):  
Petri T. Kovanen
Keyword(s):  
Mast Cells

Author response for "The role of galanin in the differentiation of mucosal mast cells in mice"

2019 ◽  
Author(s):  
Tomoko Yamaguchi ◽  
Yumi Ikeda ◽  
Katsuhisa Tashiro ◽  
Yasuyuki Ohkawa ◽  
Kenji Kawabata
Keyword(s):  
Mast Cells ◽  
Author Response ◽  
Mucosal Mast Cells

Thrombin Augments Vascular Cell-dependent Migration of Human Mast Cells: Role of MGF

1997 ◽  
Vol 77 (03) ◽  
pp. 577-584 ◽  
Author(s):  
Mehrdad Baghestanian ◽  
Roland Hofbauer ◽  
Hans G Kress ◽  
Johann Wojta ◽  
Astrid Fabry ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Mast Cells ◽  
Umbilical Vein ◽  
Vascular Cells ◽  
Migratory Response ◽  
Thrombin Activation ◽  
Umbilical Vein Endothelial Cells ◽  
Primary Tissue ◽  
Local Expression

SummaryRecent data suggest that auricular thrombosis is associated with accumulation of mast cells (MC) in the upper endocardium (where usually no MC reside) and local expression of MGF (mast cell growth factor) (25). In this study, the role of vascular cells, thrombin-activation and MGF, in MC-migration was analyzed. For this purpose, cultured human auricular endocardial cells (HAUEC), umbilical vein endothelial cells (HUVEC) and uterine-(HUTMEC) and skin-derived (HSMEC) microvascular endothelial cells were exposed to thrombin or control medium, and the migration of primary tissue MC (lung, n = 6) and HMC-1 cells (human MC-line) against vascular cells (supernatants) measured. Supernatants (24 h) of unstimulated vascular cells (monolayers of endocardium or endothelium) as well as recombinant (rh) MGF induced a significant migratory response in HMC-1 (control: 3025 ± 344 cells [100 ± 11.4%] vs. MGF, 100 ng/ml: 8806 ± 1019 [291 ± 34%] vs. HAUEC: 9703 ± 1506 [320.8 ± 49.8%] vs. HUTMEC: 8950 ± 1857 [295.9 ± 61.4%] vs. HSMEC: 9965 ± 2018 [329.4 ± 66.7%] vs. HUVEC: 9487 ± 1402 [313.6 ± 46.4%], p <0.05) as well as in primary lung MC. Thrombin-activation (5 U/ml, 12 h) of vascular cells led to an augmentation of the directed migration of MC as well as to a hirudin-sensitive increase in MGF synthesis and release. Moreover, a blocking anti-MGF antibody was found to inhibit MC-migration induced by unstimulated or thrombin-activated vascular cells. Together, these data show that endocardial and other vascular cells can induce migration of human MC. This MC-chemotactic signal of the vasculature is associated with expression and release of MGF, augmentable by thrombin, and may play a role in the pathophysiology of (auricular) thrombosis.

Role of neuropeptides in the regulation of human intestinal mast cells

1998 ◽  
Vol 114 ◽  
pp. A1081
Author(s):  
S Schwengberg ◽  
A Lorentz ◽  
MP Manns ◽  
SC Bischoff
Keyword(s):  
Mast Cells

scholarly journals Acupoint Activation: Response in Microcirculation and the Role of Mast Cells

Medicines ◽  
2014 ◽  
Vol 1 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Guangjun Wang ◽  
Daniela Litscher ◽  
Yuying Tian ◽  
Ingrid Gaischek ◽  
Shuyong Jia ◽  
...  
Keyword(s):  
Mast Cells ◽  
Activation Response

scholarly journals 2L1500 The role of transbilaver asymmetry of lipids in the exocytosis of mast cells.

2002 ◽  
Vol 42 (supplement2) ◽  
pp. S135
Author(s):  
N. Kato ◽  
M. Nakanishi ◽  
N. Hirashima
Keyword(s):  
Mast Cells

Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells

Pain ◽  
2003 ◽  
Vol 105 (3) ◽  
pp. 467-479 ◽  
Author(s):  
Yunxia Zuo ◽  
Nicholas M Perkins ◽  
David J Tracey ◽  
Carolyn L Geczy
Keyword(s):  
Mast Cells ◽  
Nerve Injury
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