Polycystic Kidney Disease Patients on Renal Replacement Therapy: Data from the Catalan Renal Registry1

2015 ◽  
pp. 177-181 ◽  
Author(s):  
R. Torra ◽  
A. Darnell ◽  
M. Cleries ◽  
A. Botey ◽  
L. Revert ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Kidney Disease ◽  
Replacement Therapy ◽  
Polycystic Kidney Disease ◽  
Polycystic Kidney

scholarly journals Renal replacement therapy in adult dominant polycystic kidney disease - multicentre study

2008 ◽  
Vol 136 (Suppl. 4) ◽  
pp. 287-293
Author(s):  
Visnja Lezaic ◽  
Vladimir Ostric ◽  
Gordana Popovic ◽  
Milja Vukoje ◽  
Branislava Dragoljic ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Kidney Disease ◽  
Replacement Therapy ◽  
Polycystic Kidney Disease ◽  
Causes Of Death ◽  
Family Members ◽  
Favourable Outcome ◽  
Polycystic Kidney ◽  
Adult Polycystic Kidney Disease ◽  
Av Fistula

INTRODUCTION. Adult polycystic kidney disease (APKD) is the most common hereditary kidney disease in humans. The course of the disease is accompanied by numerous complications. OBJECTIVE The aim was to assess the prevalence, clinical course and outcome of adult dominant polycystic kidney disease (ADPKD) patients on renal replacement therapy. METHOD. Medical data on 700 haemodialyzed (HD) and 500 transplanted patients treated in 10 Serbian centres from 1996 to 2000 were retrospectively analyzed. While ADPKD patients accounted for 13% of HD patients in Serbia in 2000, in the period between 1996 and 2000, the percent of patients with ADPKD in the population of patients starting HD in 8 examined centres changed from 13.5% to 6.9%. RESULTS. The total number of 180 ADPKD patients on HD was analyzed (96 males; aged 55 years at HD onset). Their HD lasted between 1 and 22 years: males started HD 1.3 years earlier and spent on HD 1.1 years less than females. In 53% of HD patients one or more family members had ADPKD but the cause of death was unknown for many family members. Hypertension was present in 75% of ADPKD patients, anaemia in 37% and other organ involvement (usually liver) was found in 53 patients. Fifty patients experienced AV fistula thrombosis and a vascular prosthesis had to be used in 9 of them. A hundred and two HD patients died (aged between 38 and 78 years, on HD for 5.3 years). The causes of death were stroke (19.6%), cardiovascular diseases (29%), infections, while 5% of patients died with the picture of acute abdomen. Among 500 transplanted patients, there were 20 patients with ADPKD (11 males, ages between 35 and 56 years at the time of transplantation) and 14 of them received graft from cadaver donor. Uni- or bilateral nephrectomy was done in 4 patients in the pretransplant preparation, and in another two early after transplantation due to urinary infection. Three patients restarted HD in the first 3 months after transplantation due to acute tubular necrosis and 10 patients died 56.5 months after the transplantation. The known causes of death were cardiovascular disease (3 patients), severe gastrointestinal bleeding (2 patients), infection (2 patients) and cancer (2 patients). CONCLUSION. The obtained results showed that it was possible to provide a favourable outcome of patients with APBB on renal replacement therapy in spite of numerous complications.

scholarly journals SP518PERITONEAL DIALYSIS AS A RENAL REPLACEMENT THERAPY IN PATIENTS WITH POLYCYSTIC KIDNEY DISEASE

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii303-iii303
Author(s):  
Mondher Ounissi ◽  
Marwa Omrane ◽  
Mongi Bacha ◽  
Raja Aoudia ◽  
Ezzeddine Abederrahim ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Kidney Disease ◽  
Replacement Therapy ◽  
Polycystic Kidney Disease ◽  
Polycystic Kidney

scholarly journals MP563PERITONEAL DIALYSIS AS THE FIRST-LINE RENAL REPLACEMENT THERAPY IN PATIENTS WITH AUTOSOMICAL DOMINANT POLYCYSTIC KIDNEY DISEASE

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii636-iii637 ◽  
Author(s):  
anna rachele rocca ◽  
Tania Gnerre Musto ◽  
Massimo Testorio ◽  
Alessandra Nunzi ◽  
Assunta Zavatto ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Kidney Disease ◽  
Replacement Therapy ◽  
Polycystic Kidney Disease ◽  
Polycystic Kidney ◽  
First Line

scholarly journals Demographic, diagnostic and therapeutic characteristics of autosomal dominant polycystic kidney disease in Ghana

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Perditer Okyere ◽  
Richard K.D. Ephraim ◽  
Isaac Okyere ◽  
Joseph Attakorah ◽  
Dorcas Serwaa ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Kidney Disease ◽  
Replacement Therapy ◽  
Polycystic Kidney Disease ◽  
Clinical Features ◽  
Conservative Therapy ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Autosomal Dominant Polycystic Kidney ◽  
Tract Infections

AbstractBackgroundAutosomal Dominant Polycystic Kidney Disease (ADPKD) is the commonest of the hereditary kidney diseases and mostly ensues in utero with signs delayed until after several decades. This study assessed the demographic, diagnostic (clinical and biochemical features) and therapeutic patterns among ADPKD patients who attended the nephrology unit of Komfo Anokye Teaching Hospital (KATH) from 2007 to 2018.MethodsThis cross-sectional retrospective analysis of ADPKD patient records was conducted at the nephrology unit of KATH in October 2020. The records of 82 ADPKD was used for this study. Demographic, clinical, biochemical, ultrasonographic and therapeutic data was obtained, organized and analyzed with Statistical Package for the Social Sciences (SPSS).ResultsADPKD was most prevalent in people within the ages of 31–40 years (25.6 %), with a male (52.4 %) preponderance. The most common clinical features presented were flank pain (30.5 %) and bipedal swelling (18.3 %). Hypertension (42.7 %), urinary tract infections (UTIs) (19.5 %), and anemia (13.4 %) were the most common complications reported. Average level of HDL-c was higher in females (1.7) than in males (1.2) (p = 0.001). Hematuria (34 %) and proteinuria (66 %) were among the biochemical derangements presented. About 81.7 % had CKD at diagnosis with the majority in stages 1 (27.0 %), 3(23.2 %) and 5 (20.3 %). Poor corticomedullary differentiation was observed in 90.2 % of participants and increased echogenicity was observed in 89.0 % of the participants. Estimated GFR (eGFR) correlated positively with echotexture (r = 0.320,p = 0.005) and negatively with CMD (r= -0.303,p = 0.008). About 95.1 % of patients were on conservative therapy including: 73.2 %, 52.4 %, 22.0 %, 13.4 %, 8.5 % on Irebesartan/Lisinopril, Nifecard XL, Hydralazine, Methyldopa and Bisoprolol respectively for hypertension; 26.8 and 3.7 % on Gliclazide and Metformin respectively for Type 2 diabetes mellitus; 25.6 %, 24.4 and 18.3 % on CaCO3, fersolate and folic acid respectively as nutrient supplements with 4.9 % of participants on renal replacement therapy (RRT).ConclusionsADPKD occurs in people aged ≥ 31 years with a higher male preponderance. Clinical features include flank and abdominal pain, bipedal swelling, headache, amongst others. Uremia, hematuria, proteinuria, decreased eGFR, were the common biochemical derangements reported with higher severity detected in men. The therapeutic interventions mostly involved conservative therapy to manage symptoms and other comorbid conditions and rarely renal replacement therapy (RRT).

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