The Diversification of Complement Regulatory Factor H Gene in Wild and Laboratory Mice and Its Evolutionary Relationship to the Mouse Coagulation System

2015 ◽  
pp. 211-228
Author(s):  
Shunnosuke Natsuume-Sakai ◽  
Yoshi-Nobu Harada
Keyword(s):  
Evolutionary Relationship ◽  
Factor H ◽  
Coagulation System ◽  
Laboratory Mice ◽  
Regulatory Factor ◽  
H Gene

scholarly journals Factor H gene variants in Japanese: Its relation to atypical hemolytic uremic syndrome

2011 ◽  
Vol 49 (1-2) ◽  
pp. 48-55 ◽  
Author(s):  
Saki Mukai ◽  
Yoshihiko Hidaka ◽  
Masako Hirota-Kawadobora ◽  
Kazuyuki Matsuda ◽  
Noriko Fujihara ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Factor H ◽  
Gene Variants ◽  
H Gene ◽  
Uremic Syndrome

scholarly journals Phenotype Characteristics of Patients With Age-Related Macular Degeneration Carrying a Rare Variant in the Complement Factor H Gene

2017 ◽  
Vol 135 (10) ◽  
pp. 1037 ◽  
Author(s):  
Eveline Kersten ◽  
Maartje J. Geerlings ◽  
Anneke I. den Hollander ◽  
Eiko K. de Jong ◽  
Sascha Fauser ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Rare Variant ◽  
Factor H ◽  
Age Related Macular Degeneration ◽  
Complement Factor H ◽  
Complement Factor ◽  
Age Related ◽  
H Gene

scholarly journals Complement Factor H Gene Mutation Associated with Autosomal Recessive Atypical Hemolytic Uremic Syndrome

2000 ◽  
Vol 66 (5) ◽  
pp. 1721-1722 ◽  
Author(s):  
Mark R.H. Buddles ◽  
Rosemary L. Donne ◽  
Anna Richards ◽  
Judith Goodship ◽  
Timothy H.J. Goodship
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Gene Mutation ◽  
Autosomal Recessive ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
H Gene ◽  
Uremic Syndrome

Four complement factor H gene polymorphisms in association with AMD: A meta-analysis

2016 ◽  
Vol 64 ◽  
pp. 123-129 ◽  
Author(s):  
Xuan Liao ◽  
Chang-Jun Lan ◽  
Isabella-Wai-Yin Cheuk ◽  
Qing-qing Tan
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
H Gene

scholarly journals C3 Glomerulonephritis Associated with a Missense Mutation in the Factor H Gene

2012 ◽  
Vol 227 (3) ◽  
pp. 211-215 ◽  
Author(s):  
Keisuke Sugimoto ◽  
Shinsuke Fujita ◽  
Kouhei Miyazaki ◽  
Mitsuru Okada ◽  
Tsukasa Takemura
Keyword(s):  
Missense Mutation ◽  
Factor H ◽  
C3 Glomerulonephritis ◽  
H Gene

Association of 257G>A complement factor H gene polymorphism with ischemic stroke

2007 ◽  
Vol 44 (16) ◽  
pp. 3968
Author(s):  
Gábor Széplaki ◽  
Tímea Gombos ◽  
Bernadett Blaskó ◽  
Adrienn Bíró ◽  
Zsófia Bánlaki ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Gene Polymorphism ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
H Gene

The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors

2007 ◽  
Vol 113 (4) ◽  
pp. 213-218 ◽  
Author(s):  
Klaus Stark ◽  
Katharina Neureuther ◽  
Kamil Sedlacek ◽  
Wibke Hengstenberg ◽  
Marcus Fischer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Case Control ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
H Gene ◽  
The Common

Recently, the genetic variant Y402H in the CFH (complement factor H) gene was associated with an increased risk for MI (myocardial infarction) in a prospective Caucasian cohort. In another nested case-control study, however, the CFH-Y402H variant did not carry susceptibility to MI. The aim of the present study was to test for an association between the CFH-Y402H variant and MI in a large case-control sample with a familial background for CAD (coronary artery disease). A total of 2161 individuals from the German MI family study were studied by questionnaire, physical examination and biochemical analyses. MI patients (n=1188; 51.4±8.6 years at first MI) were recruited from families with at least two members affected by MI and/or severe CAD. Spouses, sisters-in-law and brothers-in-law respectively, without MI/CAD were included as unaffected controls (n=973; 56.9±9.8 years). Genotyping was performed using a TaqMan assay. The common Y402H variant in the CFH gene was not associated with classical cardiovascular risk factors (diabetes, hypercholesterolaemia, hypertension, obesity, smoking and C-reactive protein serum levels). No association was found between the CFH-Y402H variant and susceptibility to MI. Separate analyses in both men and women revealed no gender-specific influence of the gene variant on cardiovascular risk factors or MI. This investigation was unable to replicate the association between the common CFH-Y402H variant and susceptibility to MI in our large Caucasian population which is enriched for genetic factors. We conclude that the CFH-Y402H variant has no relevant risk-modifying effect in our population.

Cloning and analysis of the human complement factor H gene promoter

1997 ◽  
Vol 75 (5) ◽  
pp. 508-510 ◽  
Author(s):  
Helena M Ward ◽  
Naomi H Higgs ◽  
Timothy K Blackmore ◽  
Tania A Sadlon ◽  
David L Gordon
Keyword(s):  
Gene Promoter ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
Human Complement ◽  
H Gene

scholarly journals Thrombotic Microangiopathy with Complement Factor H Gene Mutations Unassociated with Atypical Hemolytic Uremic Syndrome

2015 ◽  
Vol 32 (3) ◽  
pp. 275-276
Author(s):  
Yesim Oymak ◽  
Tuba Hilkay Karapınar ◽  
Yılmaz Ay ◽  
Esin Özcan ◽  
Neryal Müminoğlu ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Thrombotic Microangiopathy ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Gene Mutations ◽  
Factor H ◽  
Complement Factor H ◽  
Complement Factor ◽  
H Gene ◽  
Uremic Syndrome
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