A Dynamic Evolution of Immunoglobulin Heavy Chain Genes Revealed by the Analysis of Wild Mice

2015 ◽  
pp. 203-210
Author(s):  
Akira Shimizu
Keyword(s):  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Dynamic Evolution ◽  
Wild Mice ◽  
Immunoglobulin Heavy Chain Genes

scholarly journals CROSSING OVER BETWEEN GENES IN THE IMMUNOGLOBULIN HEAVY CHAIN LINKAGE GROUP OF THE MOUSE

1969 ◽  
Vol 130 (3) ◽  
pp. 519-541 ◽  
Author(s):  
Rose Lieberman ◽  
Michael Potter
Keyword(s):  
Linkage Group ◽  
Heavy Chain ◽  
Inbred Mice ◽  
Wild Mouse ◽  
Immunoglobulin Heavy Chain ◽  
Inbred Strains ◽  
Linkage Groups ◽  
Wild Mice ◽  
Immunoglobulin Heavy Chain Genes ◽  
Papain Digestion

Immunoglobulin heavy chain genes were found in wild mice (Mus musculus) that could best be explained as recombinants of immunoglobulin genotypes. In wild mice from Kitty Hawk, N. C., two new heavy chain linkage groups, G3,5,7,8H9,11FfA- and G3,5,8H9,11FfA-, were found, each of which genetically controls both the 3 and 5 distinct immunoglobulin determinants. In inbred strains the 3 and 5 determinants are found independently. The new heavy chain allotype G3,5,7,8H9,11FfA- probably arose from a homologous (intragenic) cross-over between G3,8H9,11FfA- and G5,7,8H9,11FfA14 heavy chain linkage groups. It was suggested that genes controlling G3,8G5,7,8, G3,5,8, and G3,5,7,8 are alleles. Another homozygous wild mouse (Kyushu, Japan) showed a new heavy chain allotype, 2G1,6,7,8H9,16FsA15. The 2 and G1,6,7,8 determinants are also separated in inbred strains. The 2 determinant in inbred mice is not on the γF, γH, or γA heavy chain and is probably on a γG or γG-like immunoglobulin heavy chain. Papain digestion of serum from the Kyushu mouse showed two electrophoretically different Fc fragments, one carrying the G1,6,7,8 and the other the 2 determinant. The new heavy chain allotype, 2G1,6,7,8H9,16FsA15, of the Kyushu wild mouse probably arose from a nonhomologous (unequal) cross over between 2G-H9,16FsA15 and G1,6,7,8H9,11FfA12,13,14 heavy chain linkage groups. The linkage group of the Kyushu wild mouse has at least five heavy chain genes, while that of the inbred mice has four.

Presence of N regions in the clonotypic DJ rearrangements of the immunoglobulin heavy-chain genes indicates an exquisitely short latency in t(4;11)-positive infant acute lymphoblastic leukemia

Blood ◽  
2001 ◽  
Vol 98 (7) ◽  
pp. 2272-2274 ◽  
Author(s):  
Karin Fasching ◽  
Simon Panzer ◽  
Oskar A. Haas ◽  
Arndt Borkhardt ◽  
Rolf Marschalek ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Heavy Chain ◽  
Lymphoblastic Leukemia ◽  
Latency Period ◽  
Immunoglobulin Heavy Chain ◽  
In Utero ◽  
Cell Precursor ◽  
Developmentally Regulated ◽  
Igh Genes ◽  
Immunoglobulin Heavy Chain Genes

Childhood acute lymphoblastic leukemia (ALL) is frequently initiated in utero at a time of developmentally regulated insertion of N regions into the DJH rearrangements of immunoglobulin heavy-chain (IgH) genes. Here it is shown that N regions are present in the clonotypic DJH rearrangements in 11 of 12 infant ALLs with t(4;11). These data are compared with the 122 previously published DJH sequences and were found to have a pattern similar to that of ALL in children older than 3 years at diagnosis but were unlike that in children younger than 3 years who predominantly lack N regions. These findings, therefore, indicate that t(4;11)-positive infant ALL is initiated later in fetal development than most B-cell precursor ALL from children younger than 3 years and that they have a shorter latency period already in utero.

scholarly journals Detection of Clone-Specific Immunoglobulin Heavy Chain Genes in the Bone Marrow of B-cell-Lineage Lymphoma after Treatment

2004 ◽  
Vol 203 (3) ◽  
pp. 155-164 ◽  
Author(s):  
Atsushi Hoshino ◽  
Tadao Funato ◽  
Yasuhiko Munakata ◽  
Tomonori Ishii ◽  
Shori Abe ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Heavy Chain ◽  
Cell Lineage ◽  
Immunoglobulin Heavy Chain ◽  
Specific Immunoglobulin ◽  
Immunoglobulin Heavy Chain Genes

Molecular origins and evolution of immunoglobulin heavy-chain genes of jawed vertebrate

1997 ◽  
Vol 18 (11) ◽  
pp. 543-549 ◽  
Author(s):  
Samuel F. Schluter ◽  
Ralph M. Bernstein ◽  
John J. Marchalonis
Keyword(s):  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Immunoglobulin Heavy Chain Genes
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