Endogenous Murine Leukemia Viruses and Host�s Resistance Gene to the Viruses in Wild Mice

2015 ◽  
pp. 67-83
Author(s):  
Hidetoshi Ikeda
Keyword(s):  
Resistance Gene ◽  
Wild Mice ◽  
Leukemia Viruses ◽  
Murine Leukemia

scholarly journals Structure and Distribution of Endogenous Nonecotropic Murine Leukemia Viruses in Wild Mice

1998 ◽  
Vol 72 (10) ◽  
pp. 8289-8300 ◽  
Author(s):  
Keizo Tomonaga ◽  
John M. Coffin
Keyword(s):  
Inbred Mice ◽  
Evolutionary Relationship ◽  
Wild Mouse ◽  
Systematic Investigation ◽  
Endogenous Retroviruses ◽  
Wild Mice ◽  
In The Wild ◽  
Leukemia Viruses ◽  
Specific Sequences ◽  
Murine Leukemia

ABSTRACT Virtually all of our present understanding of endogenous murine leukemia viruses (MLVs) is based on studies with inbred mice. To develop a better understanding of the interaction between endogenous retroviruses and their hosts, we have carried out a systematic investigation of endogenous nonecotropic MLVs in wild mice. Species studied included four major subspecies of Mus musculus(M. m. castaneus, M. m. musculus, M. m. molossinus, and M. m. domesticus) as well as four common inbred laboratory strains (AKR/J, HRS/J, C3H/HeJ, and C57BL/6J). We determined the detailed distribution of nonecotropic proviruses in the mice by using both env- and long terminal repeat (LTR)-derived oligonucleotide probes specific for the three different groups of endogenous MLVs. The analysis indicated that proviruses that react with all of the specific probes are present in most wild mouse DNAs tested, in numbers varying from 1 or 2 to more than 50. Although in common inbred laboratory strains the linkage of group-specific sequences in env and the LTR of the proviruses is strict, proviruses which combine env and the LTR sequences from different groups were commonly observed in the wild-mouse subspecies. The “recombinant” nonecotropic proviruses in the mouse genomes were amplified by PCR, and their genetic and recombinant natures were determined. These proviruses showed extended genetic variation and provide a valuable probe for study of the evolutionary relationship between MLVs and the murine hosts.

scholarly journals Virological Properties and Nucleotide Sequences of Cas-E-Type Endogenous Ecotropic Murine Leukemia Viruses in South Asian Wild Mice, Mus musculus castaneus

2001 ◽  
Vol 75 (11) ◽  
pp. 5049-5058 ◽  
Author(s):  
Hidetoshi Ikeda ◽  
Kanako Kato ◽  
Hiroshi Kitani ◽  
Takako Suzuki ◽  
Takamasa Yoshida ◽  
...  
Keyword(s):  
Mus Musculus ◽  
Antigenic Variation ◽  
Wild Mouse ◽  
Wild Mice ◽  
Multiple Copies ◽  
Restricted Region ◽  
Genomic Dnas ◽  
Spontaneous Expression ◽  
Leukemia Viruses ◽  
Murine Leukemia

ABSTRACT Two types of endogenous ecotropic murine leukemia viruses (MuLVs), termed AKV- and Cas-E-type MuLVs, differ in nucleotide sequence and distribution in wild mouse subspecies. In contrast to AKV-type MuLV, Cas-E-type MuLV is not carried by common laboratory mice. Wild mice ofMus musculus (M. m.) castaneus carry multiple copies of Cas-E-type endogenous MuLV, including the Fv-4r gene that is a truncated form of integrated MuLV and functions as a host's resistance gene against ecotropic MuLV infection. Our genetic cross experiments showed that only the Fv-4r gene was associated with resistance to ecotropic F-MuLV infection. Because the spontaneous expression of infectious virus was not detected in M. m. castaneus, we generated mice that did not carry the Fv-4r gene but did carry a single or a few endogenous MuLV loci. In mice not carrying theFv-4r gene, infectious MuLVs were isolated in association with three of six Cas-E-type endogenous MuLV loci. The isolated viruses showed a weak syncytium-forming activity for XC cells, an interfering property of ecotropic MuLV, and a slight antigenic variation. Two genomic DNAs containing endogenous Cas-E-type MuLV were cloned and partially sequenced. All of the Cas-E-type endogenous MuLVs were closely related, hybrid-type viruses with an ecotropicenv gene and a xenotropic long terminal repeat. Duplications and a deletion were found in a restricted region of the hypervariable proline-rich region of Env glycoprotein.

scholarly journals Genomes of murine leukemia viruses isolated from wild mice.

1981 ◽  
Vol 39 (3) ◽  
pp. 777-791 ◽  
Author(s):  
S K Chattopadhyay ◽  
A I Oliff ◽  
D L Linemeyer ◽  
M R Lander ◽  
D R Lowy
Keyword(s):  
Wild Mice ◽  
Leukemia Viruses ◽  
Murine Leukemia

Recent Studies on a Murine Leukemia Virus Grown in Tissue Culture

1967 ◽  
Vol 25 ◽  
pp. 106-107
Author(s):  
L. Z. de Tkaczevski ◽  
E. de Harven ◽  
C. Friend
Keyword(s):  
Tissue Culture ◽  
Solid Tumors ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Supernatant Fluid ◽  
Virus Particles ◽  
Friend Leukemia ◽  
Type C ◽  
Leukemia Viruses ◽  
Murine Leukemia

Despite extensive studies, the correlation between the morphology and pathogenicity of murine leukemia viruses (MLV) has not yet been clarified. The virus particles found in the plasma of leukemic mice belong to 2 distinct groups, 1 or 2% of them being enveloped A particles and the vast majority being of type C. It is generally believed that these 2 types of particles represent different phases in the development of the same virus. Particles of type A have been thought to be an earlier form of type C particles. One of the tissue culture lines established from Friend leukemia solid tumors has provided the material for the present study. The supernatant fluid of the line designated C-1A contains an almost pure population of A particles as illustrated in Figure 1. The ratio is, therefore, the reverse of what is unvariably observed in the plasma of leukemic mice where C particles predominate.

Mouse strain resistant to N-, B-, and NB-tropic murine leukemia viruses.

1976 ◽  
Vol 20 (2) ◽  
pp. 436-440 ◽  
Author(s):  
K Kai ◽  
H Ikeda ◽  
Y Yuasa ◽  
S Suzuki ◽  
T Odaka
Keyword(s):  
Mouse Strain ◽  
Leukemia Viruses ◽  
Murine Leukemia
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