The Role of Fatty Acid Peroxidation and Antioxidant Status in Normal Pregnancy and in Pregnancy Complicated by Preeclampsia1

2015 ◽  
pp. 114-118 ◽  
Author(s):  
Scott W. Walsh
Keyword(s):  
Fatty Acid ◽  
Antioxidant Status ◽  
Normal Pregnancy ◽  
Fatty Acid Peroxidation ◽  
In Pregnancy

scholarly journals Estrogen Receptors and Estrogen-Induced Uterine Vasodilation in Pregnancy

2020 ◽  
Vol 21 (12) ◽  
pp. 4349 ◽  
Author(s):  
Jin Bai ◽  
Qian-Rong Qi ◽  
Yan Li ◽  
Robert Day ◽  
Josh Makhoul ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Uterine Artery ◽  
Normal Pregnancy ◽  
Uterine Blood Flow ◽  
Growth And Survival ◽  
Respiratory Gases ◽  
G Protein Coupled ◽  
In Pregnancy

Normal pregnancy is associated with dramatic increases in uterine blood flow to facilitate the bidirectional maternal–fetal exchanges of respiratory gases and to provide sole nutrient support for fetal growth and survival. The mechanism(s) underlying pregnancy-associated uterine vasodilation remain incompletely understood, but this is associated with elevated estrogens, which stimulate specific estrogen receptor (ER)-dependent vasodilator production in the uterine artery (UA). The classical ERs (ERα and ERβ) and the plasma-bound G protein-coupled ER (GPR30/GPER) are expressed in UA endothelial cells and smooth muscle cells, mediating the vasodilatory effects of estrogens through genomic and/or nongenomic pathways that are likely epigenetically modified. The activation of these three ERs by estrogens enhances the endothelial production of nitric oxide (NO), which has been shown to play a key role in uterine vasodilation during pregnancy. However, the local blockade of NO biosynthesis only partially attenuates estrogen-induced and pregnancy-associated uterine vasodilation, suggesting that mechanisms other than NO exist to mediate uterine vasodilation. In this review, we summarize the literature on the role of NO in ER-mediated mechanisms controlling estrogen-induced and pregnancy-associated uterine vasodilation and our recent work on a “new” UA vasodilator hydrogen sulfide (H2S) that has dramatically changed our view of how estrogens regulate uterine vasodilation in pregnancy.

scholarly journals The role of circular Ribonucleic Acid in preeclampsia: a literature review

2020 ◽  
Vol 1 (1) ◽  
pp. 13-17
Author(s):  
William Alexander Setiawan ◽  
A.A. Gde Marvy Khrisna Pranamartha
Keyword(s):  
Literature Review ◽  
Mechanism Of Action ◽  
Normal Pregnancy ◽  
Circular Rnas ◽  
Current State ◽  
Circular Structure ◽  
Potential Applications ◽  
Non Coding Rnas ◽  
In Pregnancy

Circular RNAs (circRNAs) are non-coding RNAs with a covalently closed circular structure that present in a variety of organisms. The circRNAs are more stable and durable than linear RNAs due to incompatibility with the RNases. Recent studies have shown that circRNAs are expressed differently at the mother-fetal interface of women with preeclampsia compared to women with normal pregnancy. Although the evidence showed that circRNAs mediate various pathological processes in pregnancy, the mechanism of action is still unclear. In this paper, we provide a highlight of the current state of knowledge about circRNAs, its relation to preeclampsia, and the potential applications as preeclampsia biomarkers.

scholarly journals The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-β in Pregnancy Complicated by Placental Insufficiency

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Dorota Darmochwal-Kolarz ◽  
Magdalena Michalak ◽  
Bogdan Kolarz ◽  
Monika Przegalinska-Kalamucka ◽  
Agnieszka Bojarska-Junak ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Normal Pregnancy ◽  
Placental Insufficiency ◽  
Interleukin 17 ◽  
Maternal Peripheral Blood ◽  
Interleukin 23 ◽  
In Pregnancy

Aim. The aim of the study was to evaluate the role of Interleukin-17 (IL-17), Interleukin-23 (IL-23), and transforming growth factor-β (TGF-β) in pregnancy complicated by placental insufficiency and in normal pregnancy. Material and Methods. The study comprised 34 patients with pregnancy complicated by fetal growth restriction (FGR) associated with preeclampsia (PE), as well as 35 healthy pregnant women. The concentrations of IL-17, IL-23, and TGF-β in sera from maternal peripheral blood were determined by an immunoenzymatic assay. Results. There were higher concentrations of IL-17 in the study group when compared to the controls. In the group of patients with placental insufficiency, the levels of IL-17 positively correlated with systolic blood pressure (R=0.42, p<0.01). The study obtained comparable concentrations of IL-23 in both studied groups. The concentrations of TGF-β were significantly lower in pregnancy complicated by the insufficiency of placenta when compared to the controls. Conclusions. It seems possible that the increased concentrations of IL-17 and the deficiency of TGF-β in pregnancy complicated by FGR and PE can be responsible for the activation of inflammatory response observed in PE cases.

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

2015 ◽  
Vol 4 (3) ◽  
pp. 205 ◽  
Author(s):  
Shikha Saxena ◽  
KV Thimmaraju ◽  
PremC Srivastava ◽  
AyazK Mallick ◽  
Biswajit Das ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
In Pregnancy
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